Search Results - "Hardt, Wolf‐Dietrich"

Evolutionary causes and consequences of bacterial antibiotic persistence by Bakkeren, Erik, Diard, Médéric, Hardt, Wolf-Dietrich

“…Antibiotic treatment failure is of growing concern. Genetically encoded resistance is key in driving this process. However, there is increasing evidence that…”
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Evolution of bacterial virulence by Diard, Médéric, Hardt, Wolf-Dietrich

“…Abstract Bacterial virulence is highly dynamic and context-dependent. For this reason, it is challenging to predict how molecular changes affect the growth of…”
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Mechanisms controlling pathogen colonization of the gut by Stecher, Bärbel, Hardt, Wolf-Dietrich

“…The intestinal microbiota can protect efficiently against colonization by many enteric pathogens (‘colonization resistance’, CR). This phenomenon has been…”
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'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution by Stecher, Bärbel, Maier, Lisa, Hardt, Wolf-Dietrich

“…Perturbations in the gut microbiota can lead to a state of dysbiosis, which may involve 'blooming' of potentially harmful bacteria. Here, Hardt and colleagues…”
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Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa by Sellin, Mikael E., Müller, Anna A., Felmy, Boas, Dolowschiak, Tamas, Diard, Médéric, Tardivel, Aubry, Maslowski, Kendle M., Hardt, Wolf-Dietrich

“…The gut mucosal epithelium separates the host from the microbiota, but enteropathogens such as Salmonella Typhimurium (S.Tm) can invade and breach this…”
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Elucidating host–microbe interactions in vivo by studying population dynamics using neutral genetic tags by Hausmann, Annika, Hardt, Wolf‐Dietrich

“…Host‐microbe interactions are highly dynamic in space and time. Recent approaches – combining experiments using neutral genetic tags with stochastic population…”
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Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut by Bakkeren, Erik, Huisman, Jana S., Fattinger, Stefan A., Hausmann, Annika, Furter, Markus, Egli, Adrian, Slack, Emma, Sellin, Mikael E., Bonhoeffer, Sebastian, Regoes, Roland R., Diard, Médéric, Hardt, Wolf-Dietrich

“…The emergence of antibiotic-resistant bacteria through mutations or the acquisition of genetic material such as resistance plasmids represents a major public…”
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Multi-omic measurements of heterogeneity in HeLa cells across laboratories by Liu, Yansheng, Mi, Yang, Mueller, Torsten, Kreibich, Saskia, Williams, Evan G., Van Drogen, Audrey, Borel, Christelle, Frank, Max, Germain, Pierre-Luc, Bludau, Isabell, Mehnert, Martin, Seifert, Michael, Emmenlauer, Mario, Sorg, Isabel, Bezrukov, Fedor, Bena, Frederique Sloan, Zhou, Hu, Dehio, Christoph, Testa, Giuseppe, Saez-Rodriguez, Julio, Antonarakis, Stylianos E., Hardt, Wolf-Dietrich, Aebersold, Ruedi

“…Reproducibility in research can be compromised by both biological and technical variation, but most of the focus is on removing the latter. Here we investigate…”
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The role of microbiota in infectious disease by Stecher, Bärbel, Hardt, Wolf-Dietrich

“…The intestine harbors an ecosystem composed of the intestinal mucosa and the commensal microbiota. The microbiota fosters development, aids digestion and…”
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ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens by Proietti, Michele, Perruzza, Lisa, Scribano, Daniela, Pellegrini, Giovanni, D’Antuono, Rocco, Strati, Francesco, Raffaelli, Marco, Gonzalez, Santiago F., Thelen, Marcus, Hardt, Wolf-Dietrich, Slack, Emma, Nicoletti, Mauro, Grassi, Fabio

“…T cell dependent secretory IgA (SIgA) generated in the Peyer’s patches (PPs) of the small intestine shapes a broadly diverse microbiota that is crucial for…”
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Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract by Furter, Markus, Sellin, Mikael E., Hansson, Gunnar C., Hardt, Wolf-Dietrich

“…Mucus separates gut-luminal microbes from the tissue. It is unclear how pathogens like Salmonella Typhimurium (S.Tm) can overcome this obstacle. Using live…”
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Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness by Takizawa, Hitoshi, Fritsch, Kristin, Kovtonyuk, Larisa V., Saito, Yasuyuki, Yakkala, Chakradhar, Jacobs, Kurt, Ahuja, Akshay K., Lopes, Massimo, Hausmann, Annika, Hardt, Wolf-Dietrich, Gomariz, Álvaro, Nombela-Arrieta, César, Manz, Markus G.

“…Bacterial infection leads to consumption of short-lived innate immune effector cells, which then need to be replenished from hematopoietic stem and progenitor…”
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Inflammation boosts bacteriophage transfer between Salmonella spp by Diard, Médéric, Bakkeren, Erik, Cornuault, Jeffrey K., Moor, Kathrin, Hausmann, Annika, Sellin, Mikael E., Loverdo, Claude, Aertsen, Abram, Ackermann, Martin, De Paepe, Marianne, Slack, Emma, Hardt, Wolf-Dietrich

“…Bacteriophage transfer (lysogenic conversion) promotes bacterial virulence evolution. There is limited understanding of the factors that determine lysogenic…”
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The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen's virulence factors, and the host's mucosal immune response by Kaiser, Patrick, Diard, Médéric, Stecher, Bärbel, Hardt, Wolf-Dietrich

“…The mammalian intestine is colonized by a dense microbial community, the microbiota. Homeostatic and symbiotic interactions facilitate the peaceful…”
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Germ‐free and microbiota‐associated mice yield small intestinal epithelial organoids with equivalent and robust transcriptome/proteome expression phenotypes by Hausmann, Annika, Russo, Giancarlo, Grossmann, Jonas, Zünd, Mirjam, Schwank, Gerald, Aebersold, Ruedi, Liu, Yansheng, Sellin, Mikael E., Hardt, Wolf‐Dietrich

“…Intestinal epithelial organoids established from gut tissue have become a widely used research tool. However, it remains unclear how environmental cues,…”
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High-avidity IgA protects the intestine by enchaining growing bacteria by Moor, Kathrin, Diard, Médéric, Sellin, Mikael E., Felmy, Boas, Wotzka, Sandra Y., Toska, Albulena, Bakkeren, Erik, Arnoldini, Markus, Bansept, Florence, Co, Alma Dal, Völler, Tom, Minola, Andrea, Fernandez-Rodriguez, Blanca, Agatic, Gloria, Barbieri, Sonia, Piccoli, Luca, Casiraghi, Costanza, Corti, Davide, Lanzavecchia, Antonio, Regoes, Roland R., Loverdo, Claude, Stocker, Roman, Brumley, Douglas R., Hardt, Wolf-Dietrich, Slack, Emma

“…Oral-vaccine-induced IgA cross-links growing bacteria into clonal aggregates, inhibiting pathogenesis, adaption and the spread of antimicrobial resistance…”
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Plasmid- and strain-specific factors drive variation in ESBL-plasmid spread in vitro and in vivo by Benz, Fabienne, Huisman, Jana S., Bakkeren, Erik, Herter, Joana A., Stadler, Tanja, Ackermann, Martin, Diard, Médéric, Egli, Adrian, Hall, Alex R., Hardt, Wolf-Dietrich, Bonhoeffer, Sebastian

“…Horizontal gene transfer, mediated by conjugative plasmids, is a major driver of the global rise of antibiotic resistance. However, the relative contributions…”
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Impact of horizontal gene transfer on emergence and stability of cooperative virulence in Salmonella Typhimurium by Bakkeren, Erik, Gül, Ersin, Huisman, Jana S., Steiger, Yves, Rocker, Andrea, Hardt, Wolf-Dietrich, Diard, Médéric

“…Intestinal inflammation fuels the transmission of Salmonella Typhimurium ( S .Tm). However, a substantial fitness cost is associated with virulence expression…”
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Stabilization of cooperative virulence by the expression of an avirulent phenotype by Diard, Médéric, Garcia, Victor, Maier, Lisa, Remus-Emsermann, Mitja N. P., Regoes, Roland R., Ackermann, Martin, Hardt, Wolf-Dietrich

“…A phenotypically avirulent subpopulation of the intestinal pathogen Salmonella typhimurium promotes evolutionary stability of virulence. Salmonella 's…”
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A motile doublet form of Salmonella Typhimurium diversifies target search behavior at the epithelial surface by Ek, Viktor, Fattinger, Stefan A., Florbrant, Alexandra, Hardt, Wolf‐Dietrich, Di Martino, Maria Letizia, Eriksson, Jens, Sellin, Mikael E.

“…The behaviors of infectious bacteria are commonly studied in bulk. This is effective to define the general properties of a given isolate, but insufficient to…”
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