Search Results - "Hardingham, Giles E."

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis by Hardingham, Giles E., Do, Kim Q.

“…Impaired interneuron function is widely believed to contribute to schizophrenia pathophysiology. Hardingham and Do describe converging evidence suggesting that…”
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Coupling of the NMDA receptor to neuroprotective and neurodestructive events by Hardingham, Giles E

“…NMDA (N-methyl-D-aspartate) receptors are a subtype of ionotropic glutamate receptor with an important role in the physiology and pathophysiology of central…”
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The Regulation of Astrocytic Glutamate Transporters in Health and Neurodegenerative Diseases by Todd, Alison C, Hardingham, Giles E

“…The astrocytic glutamate transporters excitatory amino acid transporters 1 and 2 (EAAT1 and EAAT2) play a key role in nervous system function to maintain…”
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The consequences of neurodegenerative disease on neuron-astrocyte metabolic and redox interactions by Jiwaji, Zoeb, Hardingham, Giles E

“…Brain metabolic pathways relating to bioenergetic and redox homeostasis are closely linked, and deficits in these pathways are thought to occur in many…”
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Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes by Baxter, Paul S., Dando, Owen, Emelianova, Katie, He, Xin, McKay, Sean, Hardingham, Giles E., Qiu, Jing

“…Microglia, brain-resident macrophages, require instruction from the CNS microenvironment to maintain their identity and morphology and regulate inflammatory…”
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Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations by Rojo, Rocío, Raper, Anna, Ozdemir, Derya D., Lefevre, Lucas, Grabert, Kathleen, Wollscheid-Lengeling, Evi, Bradford, Barry, Caruso, Melanie, Gazova, Iveta, Sánchez, Alejandra, Lisowski, Zofia M., Alves, Joana, Molina-Gonzalez, Irene, Davtyan, Hayk, Lodge, Rebecca J., Glover, James D., Wallace, Robert, Munro, David A. D., David, Eyal, Amit, Ido, Miron, Véronique E., Priller, Josef, Jenkins, Stephen J., Hardingham, Giles E., Blurton-Jones, Mathew, Mabbott, Neil A., Summers, Kim M., Hohenstein, Peter, Hume, David A., Pridans, Clare

“…The proliferation, differentiation and survival of mononuclear phagocytes depend on signals from the receptor for macrophage colony-stimulating factor, CSF1R…”
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Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism by Hasel, Philip, Dando, Owen, Jiwaji, Zoeb, Baxter, Paul, Todd, Alison C., Heron, Samuel, Márkus, Nóra M., McQueen, Jamie, Hampton, David W., Torvell, Megan, Tiwari, Sachin S., McKay, Sean, Eraso-Pichot, Abel, Zorzano, Antonio, Masgrau, Roser, Galea, Elena, Chandran, Siddharthan, Wyllie, David J. A., Simpson, T. Ian, Hardingham, Giles E.

“…The influence that neurons exert on astrocytic function is poorly understood. To investigate this, we first developed a system combining cortical neurons and…”
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Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology by Jiwaji, Zoeb, Tiwari, Sachin S., Avilés-Reyes, Rolando X., Hooley, Monique, Hampton, David, Torvell, Megan, Johnson, Delinda A., McQueen, Jamie, Baxter, Paul, Sabari-Sankar, Kayalvizhi, Qiu, Jing, He, Xin, Fowler, Jill, Febery, James, Gregory, Jenna, Rose, Jamie, Tulloch, Jane, Loan, Jamie, Story, David, McDade, Karina, Smith, Amy M., Greer, Peta, Ball, Matthew, Kind, Peter C., Matthews, Paul M., Smith, Colin, Dando, Owen, Spires-Jones, Tara L., Johnson, Jeffrey A., Chandran, Siddharthan, Hardingham, Giles E.

“…Alzheimer’s disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly understood. TRAP-seq translatome analysis of astrocytes in APP/PS1…”
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Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis by Mehta, Arpan R., Gregory, Jenna M., Dando, Owen, Carter, Roderick N., Burr, Karen, Nanda, Jyoti, Story, David, McDade, Karina, Smith, Colin, Morton, Nicholas M., Mahad, Don J., Hardingham, Giles E., Chandran, Siddharthan, Selvaraj, Bhuvaneish T.

“…Axonal dysfunction is a common phenotype in neurodegenerative disorders, including in amyotrophic lateral sclerosis (ALS), where the key pathological…”
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Lineage divergence of activity-driven transcription and evolution of cognitive ability by Hardingham, Giles E., Pruunsild, Priit, Greenberg, Michael E., Bading, Hilmar

“…Activity-driven changes in gene transcription regulate synaptic development and function. Bading and colleagues describe recent evidence of lineage-specific…”
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Mutant C9orf72 human iPSC‐derived astrocytes cause non‐cell autonomous motor neuron pathophysiology by Zhao, Chen, Devlin, Anna‐Claire, Chouhan, Amit K., Selvaraj, Bhuvaneish T., Stavrou, Maria, Burr, Karen, Brivio, Veronica, He, Xin, Mehta, Arpan R., Story, David, Shaw, Christopher E., Dando, Owen, Hardingham, Giles E., Miles, Gareth B., Chandran, Siddharthan

“…Mutations in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS). Accumulating evidence implicates astrocytes as important…”
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The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults by Martel, Marc-André, Ryan, Tomás J., Bell, Karen F.S., Fowler, Jill H., McMahon, Aoife, Al-Mubarak, Bashayer, Komiyama, Noboru H., Horsburgh, Karen, Kind, Peter C., Grant, Seth G.N., Wyllie, David J.A., Hardingham, Giles E.

“…It is currently unclear whether the GluN2 subtype influences NMDA receptor (NMDAR) excitotoxicity. We report that the toxicity of NMDAR-mediated Ca2+ influx is…”
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Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment by Sigfridsson, Emma, Marangoni, Martina, Hardingham, Giles E, Horsburgh, Karen, Fowler, Jill H

“…Chronic cerebral hypoperfusion causes damage to the brain's white matter underpinning vascular cognitive impairment. Inflammation and oxidative stress have…”
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NMDA Receptor C-Terminal Domain Signalling in Development, Maturity, and Disease by Haddow, Kirsty, Kind, Peter C, Hardingham, Giles E

“…The NMDA receptor is a Ca -permeant glutamate receptor which plays key roles in health and disease. Canonical NMDARs contain two GluN2 subunits, of which 2A…”
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Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease by Pickett, Eleanor K., Herrmann, Abigail G., McQueen, Jamie, Abt, Kimberly, Dando, Owen, Tulloch, Jane, Jain, Pooja, Dunnett, Sophie, Sohrabi, Sadaf, Fjeldstad, Maria P., Calkin, Will, Murison, Leo, Jackson, Rosemary J., Tzioras, Makis, Stevenson, Anna, d’Orange, Marie, Hooley, Monique, Davies, Caitlin, Colom-Cadena, Marti, Anton-Fernandez, Alejandro, King, Declan, Oren, Iris, Rose, Jamie, McKenzie, Chris-Anne, Allison, Elizabeth, Smith, Colin, Hardt, Oliver, Henstridge, Christopher M., Hardingham, Giles E., Spires-Jones, Tara L.

“…A key knowledge gap blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) peptide…”
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Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals by Qiu, Jing, Tan, Yan-Wei, Hagenston, Anna M., Martel, Marc-Andre, Kneisel, Niclas, Skehel, Paul A., Wyllie, David J. A., Bading, Hilmar, Hardingham, Giles E.

“…The recent identification of the mitochondrial Ca 2+ uniporter gene (Mcu/Ccdc109a) has enabled us to address its role, and that of mitochondrial Ca 2+ uptake,…”
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C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity by Selvaraj, Bhuvaneish T., Livesey, Matthew R., Zhao, Chen, Gregory, Jenna M., James, Owain T., Cleary, Elaine M., Chouhan, Amit K., Gane, Angus B., Perkins, Emma M., Dando, Owen, Lillico, Simon G., Lee, Youn-Bok, Nishimura, Agnes L., Poreci, Urjana, Thankamony, Sai, Pray, Meryll, Vasistha, Navneet A., Magnani, Dario, Borooah, Shyamanga, Burr, Karen, Story, David, McCampbell, Alexander, Shaw, Christopher E., Kind, Peter C., Aitman, Timothy J., Whitelaw, C. Bruce A., Wilmut, Ian, Smith, Colin, Miles, Gareth B., Hardingham, Giles E., Wyllie, David J. A., Chandran, Siddharthan

“…Mutations in C9ORF72 are the most common cause of familial amyotrophic lateral sclerosis (ALS). Here, through a combination of RNA-Seq and electrophysiological…”
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Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system by Baxter, Paul S., Bell, Karen F.S., Hasel, Philip, Kaindl, Angela M., Fricker, Michael, Thomson, Derek, Cregan, Sean P., Gillingwater, Thomas H., Hardingham, Giles E.

“…How the brain’s antioxidant defenses adapt to changing demand is incompletely understood. Here we show that synaptic activity is coupled, via the NMDA receptor…”
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Long-term plasticity of astrocytic phenotypes and their control by neurons in health and disease by Wardlaw, Kyle S, Hardingham, Giles E

“…The brain is a complex organ even when viewed from a cell biological perspective. Neuronal networks are embedded in a dense milieu of diverse and specialised…”
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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways by Bading, Hilmar, Hardingham, Giles E, Fukunaga, Yuko

“…Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors have opposite effects on CREB (cAMP response element binding protein)…”
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