Search Results - "Harding, Joseph W."

Angiotensin II-Mediated Microvascular Thrombosis by Senchenkova, Elena Y, Russell, Janice, Almeida-Paula, Lidiana D, Harding, Joseph W, Granger, D. Neil

“…Hypertension is associated with an increased risk of thrombosis that appears to involve an interaction between the renin-angiotensin system and hemostasis. In…”
Get full text

The brain renin–angiotensin system: a diversity of functions and implications for CNS diseases by Wright, John W., Harding, Joseph W.

Get full text

Effects of extracellular matrix‐degrading proteases matrix metalloproteinases 3 and 9 on spatial learning and synaptic plasticity by Meighan, Starla E., Meighan, Peter C., Choudhury, Papiya, Davis, Christopher J., Olson, Mikel L., Zornes, Peter A., Wright, John W., Harding, Joseph W.

“…Rats learning the Morris water maze exhibit hippocampal changes in synaptic morphology and physiology that manifest as altered synaptic efficacy. Learning…”
Get full text

The brain angiotensin system and extracellular matrix molecules in neural plasticity, learning, and memory by Wright, John W, Harding, Joseph W

“…The brain renin-angiotensin system (RAS) has long been known to regulate several classic physiologies including blood pressure, sodium and water balance,…”
Get full text

Pathways involved in the transition from hypertension to hypertrophy to heart failure. Treatment strategies by Wright, John W., Mizutani, Shigehiko, Harding, Joseph W.

“…The renin-angiotensin-aldosterone system (RAAS) is critical in regulating systemic blood pressure, water and electrolyte balance, and pituitary gland hormones…”
Get full text

Contributions of Matrix Metalloproteinases to Neural Plasticity, Habituation, Associative Learning and Drug Addiction by Wright, John W., Harding, Joseph W.

“…The premise of this paper is that increased expression of matrix metalloproteinases (MMPs) permits the reconfiguration of synaptic connections (i.e., neural…”
Get full text

Effects of matrix metalloproteinase inhibition on short- and long-term plasticity of schaffer collateral/CA1 synapses by Meighan, Peter C, Meighan, Starla E, Davis, Christopher J, Wright, John W, Harding, Joseph W

“…It is increasingly evident that matrix metalloproteinases (MMPs), a family of zinc containing extracellular endopeptidases, participate in processes supporting…”
Get full text

Role of Matrix Metalloproteinases in the Acquisition and Reconsolidation of Cocaine-Induced Conditioned Place Preference by Brown, Travis E, Forquer, Melissa R, Cocking, Davelle L, Jansen, Heiko T, Harding, Joseph W, Sorg, Barbara A

“…Persistent drug seeking/taking behavior involves the consolidation of memory. With each drug use, the memory may be reactivated and reconsolidated to maintain…”
Get full text

Contributions by the Brain Renin-Angiotensin System to Memory, Cognition, and Alzheimer's Disease by Wright, John W, Harding, Joseph W

“…Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive neuron losses in memory-associated brain structures that rob patients of…”
Get more information

The brain renin–angiotensin system: a diversity of functions and implications for CNS diseases by Wright, John W., Harding, Joseph W.

“…The classic renin–angiotensin system (RAS) was initially described as a hormone system designed to mediate cardiovascular and body water regulation, with…”
Get full text

Brain renin-angiotensin--a new look at an old system by Wright, John W, Harding, Joseph W

“…The classic renin-angiotensin system (RAS) is described as a circulating hormone system focused on cardiovascular and body water regulation, with angiotensin…”
Get full text

Importance of the Brain Angiotensin System in Parkinson’s Disease by Wright, John W., Harding, Joseph W.

“…Parkinson’s disease (PD) has become a major health problem affecting 1.5% of the world’s population over 65 years of age. As life expectancy has increased so…”
Get full text

Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension by Wright, John W., Harding, Joseph W., Mizutani, Shigehiko

“…The classic renin-angiotensin system (RAS) was initially described as a hormone system designed to mediate cardiovascular and body water regulation. The…”
Get full text

Increase in matrix metalloproteinase-9 levels in the rat medial prefrontal cortex after cocaine reinstatement of conditioned place preference by Brown, Travis E., Forquer, Melissa R., Harding, Joseph W., Wright, John W., Sorg, Barbara A.

“…Recently we have shown that inhibition of matrix metalloproteinase (MMP) activity suppresses the reinstatement of cocaine‐primed conditioned place preference…”
Get full text

Nanoscale mapping of the Met receptor on hippocampal neurons by AFM and confocal microscopy by Kawas, Leen H., PhD, Benoist, Caroline C., PhD, Harding, Joseph W., PhD, Wayman, Gary A., PhD, Abu-Lail, Nehal I., PhD

“…Abstract Hepatocyte growth factor (HGF), a neurotrophic protein, acting through its tyrosine kinase receptor, Met, facilitates learning and synaptic…”
Get full text

REM sleep deprivation-induced deficits in the latency-to-peak induction and maintenance of long-term potentiation within the CA1 region of the hippocampus by Davis, Christopher J., Harding, Joseph W., Wright, John W.

“…Sleep loss adversely affects certain types of cognitive processing, particularly associative memory. Given that long-term potentiation (LTP) represents a…”
Get full text

A Role for the Brain RAS in Alzheimer's and Parkinson's Diseases by Wright, John W, Kawas, Leen H, Harding, Joseph W

“…The brain renin-angiotensin system (RAS) has available the necessary functional components to produce the active ligands angiotensins II (AngII), angiotensin…”
Get full text

Inhibition of hippocampal matrix metalloproteinase-3 and -9 disrupts spatial memory by Wright, John W, Brown, Travis E, Harding, Joseph W

“…Memory consolidation requires synaptic reconfiguration dependent upon extracellular matrix (ECM) molecules interacting with cell adhesion molecules. Matrix…”
Get full text

The brain RAS and Alzheimer's disease by Wright, John W., Harding, Joseph W.

“…Alzheimer's disease (AD) has become a major world-wide health problem with ever rising costs associated with the treatment and care of afflicted individuals…”
Get full text

The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases by Wright, John W, Kawas, Leen H, Harding, Joseph W

“…Alzheimer's (AD) and Parkinson's (PD) diseases are neurodegenerative diseases presently without effective drug treatments. AD is characterized by general…”
Get full text