Search Results - "Harding, James P"

Synthesis and Pharmacological Evaluation of Novel γ-Aminobutyric Acid Type B (GABAB) Receptor Agonists as Gastroesophageal Reflux Inhibitors by Alstermark, Christer, Amin, Kosrat, Dinn, Sean R, Elebring, Thomas, Fjellström, Ola, Fitzpatrick, Kevin, Geiss, William B, Gottfries, Johan, Guzzo, Peter R, Harding, James P, Holmén, Anders, Kothare, Mohit, Lehmann, Anders, Mattsson, Jan P, Nilsson, Karolina, Sundén, Gunnel, Swanson, Marianne, von Unge, Sverker, Woo, Alex M, Wyle, Michael J, Zheng, Xiaozhang

“…We have previously demonstrated that the prototypical GABAB receptor agonist baclofen inhibits transient lower esophageal sphincter relaxations (TLESRs), the…”
Get full text

Discovery of 2-substituted benzoxazole carboxamides as 5-HT3 receptor antagonists by Yang, Zhicai, Fairfax, David J., Maeng, Jun-Ho, Masih, Liaqat, Usyatinsky, Alexander, Hassler, Carla, Isaacson, Soshanna, Fitzpatrick, Kevin, DeOrazio, Russell J., Chen, Jianqing, Harding, James P., Isherwood, Matthew, Dobritsa, Svetlana, Christensen, Kevin L., Wierschke, Jonathan D., Bliss, Brian I., Peterson, Lisa H., Beer, Cathy M., Cioffi, Christopher, Lynch, Michael, Rennells, W. Martin, Richards, Justin J., Rust, Timothy, Khmelnitsky, Yuri L., Cohen, Marlene L., Manning, David D.

“…The discovery of a novel series of benzoxazole-4-carboxamides is described. A structure–activity relationship study resulted in the identification of 2-amino…”
Get full text

Discovery of 2-substituted benzoxazole carboxamides as 5-HT sub(3) receptor antagonists by Yang, Zhicai, Fairfax, David J, Maeng, Jun-Ho, Masih, Liaqat, Usyatinsky, Alexander, Hassler, Carla, Isaacson, Soshanna, Fitzpatrick, Kevin, DeOrazio, Russell J, Chen, Jianqing, Harding, James P, Isherwood, Matthew, Dobritsa, Svetlana, Christensen, Kevin L, Wierschke, Jonathan D, Bliss, Brian I, Peterson, Lisa H, Beer, Cathy M, Cioffi, Christopher, Lynch, Michael

“…A new class of 2-substituted benzoxazole carboxamides are presented as potent functional 5-HT sub(3) receptor antagonists. The chemical series possesses…”
Get full text