Search Results - "Harding, Christian M."

Uncovering the mechanisms of Acinetobacter baumannii virulence by Harding, Christian M., Hennon, Seth W., Feldman, Mario F.

“…Key Points Acinetobacter baumannii is an opportunistic human pathogen that predominantly causes health-care-associated infections. Many members of the genus…”
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Capsular polysaccharide inhibits vaccine-induced O-antigen antibody binding and function across both classical and hypervirulent K2:O1 strains of Klebsiella pneumoniae by Wantuch, Paeton L, Knoot, Cory J, Robinson, Lloyd S, Vinogradov, Evgeny, Scott, Nichollas E, Harding, Christian M, Rosen, David A

“…Klebsiella pneumoniae presents as two circulating pathotypes: classical K. pneumoniae (cKp) and hypervirulent K. pneumoniae (hvKp). Classical isolates are…”
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A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host by Harding, Christian M., Nasr, Mohamed A., Scott, Nichollas E., Goyette-Desjardins, Guillaume, Nothaft, Harald, Mayer, Anne E., Chavez, Sthefany M., Huynh, Jeremy P., Kinsella, Rachel L., Szymanski, Christine M., Stallings, Christina L., Segura, Mariela, Feldman, Mario F.

“…Chemical synthesis of conjugate vaccines, consisting of a polysaccharide linked to a protein, can be technically challenging, and in vivo bacterial…”
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Medically Relevant Acinetobacter Species Require a Type II Secretion System and Specific Membrane-Associated Chaperones for the Export of Multiple Substrates and Full Virulence by Harding, Christian M, Kinsella, Rachel L, Palmer, Lauren D, Skaar, Eric P, Feldman, Mario F

“…Acinetobacter baumannii, A. nosocomialis, and A. pittii have recently emerged as opportunistic human pathogens capable of causing severe human disease;…”
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Acinetobacter baumannii strain M2 produces type IV pili which play a role in natural transformation and twitching motility but not surface-associated motility by Harding, Christian M, Tracy, Erin N, Carruthers, Michael D, Rather, Philip N, Actis, Luis A, Munson, Jr, Robert S

“…Acinetobacter baumannii is a Gram-negative, opportunistic pathogen. Recently, multiple A. baumannii genomes have been sequenced; these data have led to the…”
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KatG and KatE confer Acinetobacter resistance to hydrogen peroxide but sensitize bacteria to killing by phagocytic respiratory burst by Sun, Daqing, Crowell, Sara A., Harding, Christian M., De Silva, P. Malaka, Harrison, Alistair, Fernando, Dinesh M., Mason, Kevin M., Santana, Estevan, Loewen, Peter C., Kumar, Ayush, Liu, Yusen

“…Catalase catalyzes the degradation of H2O2. Acinetobacter species have four predicted catalase genes, katA, katE, katG, and katX. The aims of the present study…”
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Characteristics of invasive Acinetobacter species isolates recovered in a pediatric academic center by Jain, Avish L, Harding, Christian M, Assani, Kaivon, Shrestha, Chandra L, Haga, Mercedees, Leber, Amy, Munson, Jr, Robert S, Kopp, Benjamin T

“…Acinetobacter species are associated with increasing mortality due to emerging drug-resistance. Pediatric Acinetobacter infections are largely undefined in…”
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Glycoengineering bioconjugate vaccines, therapeutics, and diagnostics in E. coli by Harding, Christian M, Feldman, Mario F

“…The first, general glycosylation pathway in bacteria, the N-linked glycosylation system of Campylobacter jejuni, was discovered two decades ago. Since then,…”
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Pathogenic Acinetobacter: from the Cell Surface to Infinity and Beyond by Weber, Brent S, Harding, Christian M, Feldman, Mario F

“…The genus Acinetobacter encompasses multiple nosocomial opportunistic pathogens that are of increasing worldwide relevance because of their ability to survive…”
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A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae by Feldman, Mario F., Bridwell, Anne E. Mayer, Scott, Nichollas E., Vinogradov, Evgeny, McKee, Samuel R., Chavez, Sthefany M., Twentyman, Joy, Stallings, Christina L., Rosen, David A., Harding, Christian M.

“…Hypervirulent Klebsiella pneumoniae (hvKp) is globally disseminating as a community-acquired pathogen causing life-threatening infections in healthy…”
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The Secrets of Acinetobacter Secretion by Weber, Brent S, Kinsella, Rachel L, Harding, Christian M, Feldman, Mario F

“…Infections caused by the bacterial pathogen Acinetobacter baumannii are a mounting concern for healthcare practitioners as widespread antibiotic resistance…”
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A minimal sequon sufficient for O-linked glycosylation by the versatile oligosaccharyltransferase PglS by Knoot, Cory J, Robinson, Lloyd S, Harding, Christian M

“…Abstract Bioconjugate vaccines, consisting of polysaccharides attached to carrier proteins, are enzymatically generated using prokaryotic glycosylation systems…”
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Heptavalent O-Antigen Bioconjugate Vaccine Exhibiting Differential Functional Antibody Responses Against Diverse Klebsiella pneumoniae Isolates by Wantuch, Paeton L, Knoot, Cory J, Robinson, Lloyd S, Vinogradov, Evgeny, Scott, Nichollas E, Harding, Christian M, Rosen, David A

“…Abstract Klebsiella pneumoniae is the leading cause of neonatal sepsis and is increasingly difficult to treat owing to antibiotic resistance. Vaccination…”
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Discovery and characterization of a new class of O-linking oligosaccharyltransferases from the Moraxellaceae family by Knoot, Cory J, Wantuch, Paeton L, Robinson, Lloyd S, Rosen, David A, Scott, Nichollas E, Harding, Christian M

“…Bacterial protein glycosylation is commonly mediated by oligosaccharyltransferases (OTases) that transfer oligosaccharides en bloc from preassembled…”
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Distinct amino acid residues confer one of three UDP-sugar substrate specificities in Acinetobacter baumannii PglC phosphoglycosyltransferases by Harding, Christian M, Haurat, M Florencia, Vinogradov, Evgeny, Feldman, Mario F

“…Acinetobacter baumannii is an opportunistic human pathogen with the highest reported rates of multidrug resistance among Gram-negative pathogens. The capsular…”
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Pathogenic Acinetobacter species have a functional type I secretion system and contact-dependent inhibition systems by Harding, Christian M., Pulido, Marina R., Di Venanzio, Gisela, Kinsella, Rachel L., Webb, Andrew I., Scott, Nichollas E., Pachón, Jerónimo, Feldman, Mario F.

“…Pathogenic Acinetobacter species, including Acinetobacter baumannii and Acinetobacter nosocomialis, are opportunistic human pathogens of increasing relevance…”
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Structural Diversity in the Type IV Pili of Multidrug-resistant Acinetobacter by Piepenbrink, Kurt H., Lillehoj, Erik, Harding, Christian M., Labonte, Jason W., Zuo, Xiaotong, Rapp, Chelsea A., Munson, Robert S., Goldblum, Simeon E., Feldman, Mario F., Gray, Jeffrey J., Sundberg, Eric J.

“…Acinetobacter baumannii is a Gram-negative coccobacillus found primarily in hospital settings that has recently emerged as a source of hospital-acquired…”
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Acinetobacter strains carry two functional oligosaccharyltransferases, one devoted exclusively to type IV pilin, and the other one dedicated to O‐glycosylation of multiple proteins by Harding, Christian M., Nasr, Mohamed A., Kinsella, Rachel L., Scott, Nichollas E., Foster, Leonard J., Weber, Brent S., Fiester, Steve E., Actis, Luis A., Tracy, Erin N., Munson, Robert S., Feldman, Mario F.

“…Summary Multiple species within the Acinetobacter genus are nosocomial opportunistic pathogens of increasing relevance worldwide. Among the virulence factors…”
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Immunogenicity and protective efficacy of a prototype pneumococcal bioconjugate vaccine by Aceil, Javid, Paschall, Amy V., Knoot, Cory J., Robinson, Lloyd S., Scott, Nichollas E., Feldman, Mario F., Harding, Christian M., Avci, Fikri Y.

“…•Bioconjugation is an effective alternative for chemical conjugate vaccine design.•CPS8-EPAiGTcc induces robust immune response regardless of biological sex or…”
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Development and Immunogenicity of a Prototype Multivalent Group B Streptococcus Bioconjugate Vaccine by Duke, Jeremy A., Paschall, Amy V., Robinson, Lloyd S., Knoot, Cory J., Vinogradov, Evgeny, Scott, Nichollas E., Feldman, Mario F., Avci, Fikri Y., Harding, Christian M.

“…Group B Streptococcus (GBS) is a leading cause of neonatal infections and invasive diseases in nonpregnant adults worldwide. Developing a protective conjugate…”
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