Search Results - "Harder, J A"

Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties by Schechter, L E, Smith, D L, Rosenzweig-Lipson, S, Sukoff, S J, Dawson, L A, Marquis, K, Jones, D, Piesla, M, Andree, T, Nawoschik, S, Harder, J A, Womack, M D, Buccafusco, J, Terry, A V, Hoebel, B, Rada, P, Kelly, M, Abou-Gharbia, M, Barrett, J E, Childers, W

“…Recent data has suggested that the 5-hydroxytryptamine (5-HT)(1A) receptor is involved in cognitive processing. A novel 5-HT(1A) receptor antagonist,…”
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Functional Magnetic Resonance Imaging in Conscious Animals: A New Tool in Behavioural Neuroscience Research by Ferris, C. F., Febo, M., Luo, F., Schmidt, K., Brevard, M., Harder, J. A., Kulkarni, P., Messenger, T., King, J. A.

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The 5-HT1A antagonist, WAY 100 635, alleviates cognitive impairments induced by dizocilpine (MK-801) in monkeys by HARDER, J. A, RIDLEY, R. M

“…Central glutamate neurotransmission is modulated by an upregulatory cholinergic influence and an inhibitory serotonergic influence. In Alzheimer's disease,…”
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Learning impairments induced by glutamate blockade using dizocilpine (MK‐801) in monkeys by Harder, J. A., Aboobaker, A. A., Hodgetts, T. C., Ridley, R. M.

“…1 This study investigated the effects of dizocilpine (MK‐801) on learning ability in a non‐human primate. Acquisition and reversal learning of visual…”
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The Role of the Central Cholinergic Projections in Cognition: Implications of the Effects of Scopolamine on Discrimination Learning by Monkeys by Harder, J.A, Baker, H.F, Ridley, R.M

“…In humans, administration of the cholinergic antagonist scopolamine impairs the encoding of information into long-term memory and has effects on other…”
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Effects of lesions of different parts of the septo-hippocampal system in primates on learning and retention of information acquired before or after surgery by Ridley, R.M., Baker, H.F., Harder, J.A., Pearson, C.

“…Data from a large series of experiments on marmosets with lesions of the septal/diagonal band area (DB), fornix or CA1 area of the hippocampus are analysed in…”
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Combined pCPA and muscarinic antagonist treatment produces a deficit in rat water maze acquisition by Harder, J.A., Kelly, M.E., Cheng, C.H.K., Costall, B.

“…A 3-day treatment with p-chlorophenylalanine (pCPA, 100 mg/kg/day) produced a significant decrease (63–89%) in 5-HT levels in both the hippocampus and the…”
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The Effect of Several Putative Cognition Enhancers on a Water Maze Acquisition Deficit Produced by pCPA + Scopolamine Combination Treatment by Harder, J.A, Kelly, M.E

“…A combined treatment of a 3-day regimen of pCPA and low-dose scopolamine produced a significant deficit in the acquisition of a water maze task, which has been…”
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Normative ground reaction force data for able-bodied and trans-tibial amputee children during running by Engsberg, J R, Lee, A G, Tedford, K G, Harder, J A

“…The purpose of this investigation was to develop normative ground reaction force data for able-bodied (AB) and trans-tibial amputee (TTA) children during…”
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The 5-HT1A antagonist, WAY 100635, ameliorates the cognitive impairment induced by fornix transection in the marmoset by HARDER, J. A, MACLEAN, C. J, ALDER, J. T, FRANCIS, P. T, RIDLEY, R. M

“…Fornix transection in the marmoset produces a specific pattern of cognitive deficits, notably a lack of ability to recall visuospatial tasks learnt…”
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Normative ground reaction force data for able-bodied and below-knee-amputee children during walking by Engsberg, J R, Lee, A G, Tedford, K G, Harder, J A

“…We determined normative ground reaction force data for able-bodied (AB) and below-knee-amputee (BKA) children during walking. Twenty-two BKA and 225…”
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External loading comparisons between able-bodied and below-knee-amputee children during walking by Engsberg, J R, Lee, A G, Patterson, J L, Harder, J A

“…The purpose of this investigation was to determine external loading variables that could describe any statistically significant differences between the limbs…”
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Progesterone inhibits arterial smooth muscle cell proliferation by Lee, W S, Harder, J A, Yoshizumi, M, Lee, M E, Haber, E

“…Mortality from atherosclerotic cardiovascular disease is lower in premenopausal women than in age-matched men. It is also lower in postmenopausal women who…”
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Center of mass location and segment angular orientation of below-knee-amputee and able-bodied children during walking by Engsberg, J R, Tedford, K G, Harder, J A

“…This investigation compared the center of mass (COM) locations and segment angular orientations of the gait of below-knee-amputee (BKA) children to those of…”
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Neutron detector development at Brookhaven by Yu, B., Harder, J.A., Mead, J.A., Radeka, V., Schaknowski, N.A., Smith, G.C.

“…Two-dimensional thermal neutron detectors have been the subject of research and development at Brookhaven for over 20 years. Based primarily on multi-wire…”
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A CAD CAM method for custom below-knee sockets by Engsberg, J R, Clynch, G S, Lee, A G, Allan, J S, Harder, J A

“…The purpose of this investigation was to develop a numerical method for fabricating prosthetic sockets for below-knee amputees. An optical/laser digitiser…”
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A pilot study to test the influence of specific prosthetic features in preventing trans-tibial amputees from walking like able-bodied subjects by Stefanyshyn, D J, Engsberg, J R, Tedford, K G, Harder, J A

“…The purpose of this pilot investigation was to develop a method to test the influence of specific prosthetic features in preventing trans-tibial amputees from…”
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A large, high performance, curved 2D position-sensitive neutron detector by Fried, J., Harder, J.A., Mahler, G.J., Makowiecki, D.S., Mead, J.A., Radeka, V., Schaknowski, N.A., Smith, G.C., Yu, B.

“…A new position-sensitive neutron detector has been designed and constructed for a protein crystallography station at LANL's pulsed neutron source. This station…”
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Weight distribution of below-knee amputee and able-bodied children during standing by Engsberg, J R, Tedford, K G, Springer, M J, Harder, J A

“…The purpose of this investigation was to compare weight distributions of a relatively large number of below-knee (BK) amputee and able-bodied children during…”
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Front-end electronics for high rate, position sensitive neutron detectors by Yu, B, Zojceski, Z, Harder, J.A, Hrisoho, A, Radeka, V, Smith, G.C

“…Advanced neutron detectors for experiments at new spallation sources will require greater counting rate capabilities than previously attainable. This…”
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