Search Results - "Hardeland, Ruediger"

Targeting Host Defense System and Rescuing Compromised Mitochondria to Increase Tolerance against Pathogens by Melatonin May Impact Outcome of Deadly Virus Infection Pertinent to COVID-19 by Tan, Dun-Xian, Hardeland, Ruediger

“…Fighting infectious diseases, particularly viral infections, is a demanding task for human health. Targeting the pathogens or targeting the host are different…”
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Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions by Slominski, Andrzej T., Hardeland, Ruediger, Zmijewski, Michal A., Slominski, Radomir M., Reiter, Russel J., Paus, Ralf

“…Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the main neuroendocrine secretory product of the pineal gland…”
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Melatonin: Both a Messenger of Darkness and a Participant in the Cellular Actions of Non-Visible Solar Radiation of Near Infrared Light by Tan, Dun-Xian, Reiter, Russel J, Zimmerman, Scott, Hardeland, Ruediger

“…Throughout the history of melatonin research, almost exclusive focus has been on nocturnally-generated pineal melatonin production, which accounts for its…”
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Fundamental issues related to the origin of melatonin and melatonin isomers during evolution: relation to their biological functions by Tan, Dun-Xian, Zheng, Xiaodong, Kong, Jin, Manchester, Lucien C, Hardeland, Ruediger, Kim, Seok Joong, Xu, Xiaoying, Reiter, Russel J

“…Melatonin and melatonin isomers exist and/or coexist in living organisms including yeasts, bacteria and plants. The levels of melatonin isomers are…”
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Protecting the melatonin rhythm through circadian healthy light exposure by Bonmati-Carrion, Maria Angeles, Arguelles-Prieto, Raquel, Martinez-Madrid, Maria Jose, Reiter, Russel, Hardeland, Ruediger, Rol, Maria Angeles, Madrid, Juan Antonio

“…Currently, in developed countries, nights are excessively illuminated (light at night), whereas daytime is mainly spent indoors, and thus people are exposed to…”
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Pathophysiology of depression: Role of sleep and the melatonergic system by Srinivasan, Venkataramanujan, Pandi-Perumal, Seithikurippu R, Trakht, Ilya, Spence, D.Warren, Hardeland, Ruediger, Poeggeler, Burkhard, Cardinali, Daniel P

“…Abstract Profound disturbances in sleep architecture occur in major depressive disorders (MDD) and in bipolar affective disorders. Reduction in slow wave…”
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Melatonin and inflammation—Story of a double‐edged blade by Hardeland, Rüdiger

“…Melatonin is an immune modulator that displays both pro‐ and anti‐inflammatory properties. Proinflammatory actions, which are well documented by many studies…”
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Melatonin and the electron transport chain by Hardeland, Rüdiger

“…Melatonin protects the electron transport chain (ETC) in multiple ways. It reduces levels of ·NO by downregulating inducible and inhibiting neuronal nitric…”
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Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks by Hardeland, Rüdiger

“…Aging and various age-related diseases are associated with reductions in melatonin secretion, proinflammatory changes in the immune system, a deteriorating…”
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Melatonin in aging and disease -multiple consequences of reduced secretion, options and limits of treatment by Hardeland, Rüdiger

“…Melatonin is a pleiotropically acting regulator molecule, which influences numerous physiological functions. Its secretion by the pineal gland progressively…”
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Melatonin in Plants - Diversity of Levels and Multiplicity of Functions by Hardeland, Rüdiger

“…Melatonin has been detected in numerous plant species. A particularly surprising finding concerns the highly divergent levels of melatonin that vary between…”
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Melatonin and Microglia by Hardeland, Rüdiger

“…Melatonin interacts in multiple ways with microglia, both directly and, via routes of crosstalk with astrocytes and neurons, indirectly. These effects of…”
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Redox Biology of Melatonin: Discriminating Between Circadian and Noncircadian Functions by Hardeland, Rüdiger

“…Melatonin has not only to be seen as a regulator of circadian clocks. In addition to its chronobiotic functions, it displays other actions, especially in cell…”
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Melatonin in plants and other phototrophs: advances and gaps concerning the diversity of functions by Hardeland, Rüdiger

“…Melatonin is synthesized in Alphaproteobacteria, Cyanobacteria, Dinoflagellata, Euglenoidea, Rhodophyta, Phaeophyta, and Viridiplantae. The biosynthetic…”
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Melatonin and the pathologies of weakened or dysregulated circadian oscillators by Hardeland, Rüdiger

“…Dynamic aspects of melatonin's actions merit increasing future attention. This concerns particularly entirely different effects in senescent, weakened…”
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Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms by Hardeland, Rüdiger

“…The classic theories of aging such as the free radical theory, including its mitochondria‐related versions, have largely focused on a few specific processes of…”
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Taxon- and Site-Specific Melatonin Catabolism by Hardeland, Rüdiger

“…Melatonin is catabolized both enzymatically and nonenzymatically. Nonenzymatic processes mediated by free radicals, singlet oxygen, other reactive…”
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Melatonin and the Programming of Stem Cells by Hardeland, Rüdiger

“…Melatonin interacts with various types of stem cells, in multiple ways that comprise stimulation of proliferation, maintenance of stemness and self-renewal,…”
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On the primary functions of melatonin in evolution: mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals by Hardeland, R, Balzer, I, Poeggeler, B, Fuhrberg, B, Uría, H, Behrmann, G, Wolf, R, Meyer, T J, Reiter, R J

“…Melatonin is widely abundant in many eukaryotic taxa, including various animal phyla, angiosperms, and unicells. In the bioluminescent dinoflagellate Gonyaulax…”
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Inflammaging, Metabolic Syndrome and Melatonin: A Call for Treatment Studies by Cardinali, Daniel P, Hardeland, Rüdiger

“…The metabolic syndrome (MS) is a collection of risk factors for cardiovascular disease, including obesity, hypertension, hyperinsulinemia, glucose intolerance…”
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