Search Results - "Hardcastle, Sarah A."

Pregnancy and Lactation Associated Osteoporosis by Hardcastle, Sarah A.

“…Pregnancy-associated osteoporosis (PAO) is a rare condition of skeletal fragility affecting women in pregnancy or the postpartum period. During normal…”
Get full text

LRP5 Regulates Human Body Fat Distribution by Modulating Adipose Progenitor Biology in a Dose- and Depot-Specific Fashion by Loh, Nellie Y., Neville, Matt J., Marinou, Kyriakoula, Hardcastle, Sarah A., Fielding, Barbara A., Duncan, Emma L., McCarthy, Mark I., Tobias, Jonathan H., Gregson, Celia L., Karpe, Fredrik, Christodoulides, Constantinos

“…Common variants in WNT pathway genes have been associated with bone mass and fat distribution, the latter predicting diabetes and cardiovascular disease risk…”
Get full text

Increased development of radiographic hip osteoarthritis in individuals with high bone mass: a prospective cohort study by Hartley, April, Hardcastle, Sarah A, Frysz, Monika, Parkinson, Jon, Paternoster, Lavinia, McCloskey, Eugene, Poole, Kenneth E S, Javaid, Muhammad K, Aye, Mo, Moss, Katie, Williams, Martin, Tobias, Jon H, Gregson, Celia L

“…Individuals with high bone mass (HBM) have a greater odds of prevalent radiographic hip osteoarthritis (OA), reflecting an association with bone-forming OA…”
Get full text

Reduced Kidney Function in Rheumatoid Arthritis: Rheumatologists Have a Role by Hardcastle, Sarah A., MBChB, Williamson, Lyn, FRCP

Get full text

Mutations in Known Monogenic High Bone Mass Loci Only Explain a Small Proportion of High Bone Mass Cases by Gregson, Celia L, Wheeler, Lawrie, Hardcastle, Sarah A, Appleton, Louise H, Addison, Kathryn A, Brugmans, Marieke, Clark, Graeme R, Ward, Kate A, Paggiosi, Margaret, Stone, Mike, Thomas, Joegi, Agarwal, Rohan, Poole, Kenneth ES, McCloskey, Eugene, Fraser, William D, Williams, Eleanor, Bullock, Alex N, Davey Smith, George, Brown, Matthew A, Tobias, Jon H, Duncan, Emma L

“…ABSTRACT High bone mass (HBM) can be an incidental clinical finding; however, monogenic HBM disorders (eg, LRP5 or SOST mutations) are rare. We aimed to…”
Get full text

Osteoarthritis and bone mineral density: are strong bones bad for joints? by Hardcastle, Sarah A, Dieppe, Paul, Gregson, Celia L, Davey Smith, George, Tobias, Jon H

“…Osteoarthritis (OA) is a common and disabling joint disorder affecting millions of people worldwide. In OA, pathological changes are seen in all of the joint…”
Get full text

Friend or foe: high bone mineral density on routine bone density scanning, a review of causes and management by Gregson, Celia L, Hardcastle, Sarah A, Cooper, Cyrus, Tobias, Jonathan H

“…A finding of high BMD on routine DXA scanning is not infrequent and most commonly reflects degenerative disease. However, BMD increases may also arise…”
Get full text

Jump Power and Force Have Distinct Associations With Cortical Bone Parameters: Findings From a Population Enriched by Individuals With High Bone Mass by Hardcastle, Sarah A, Gregson, Celia L, Rittweger, Jörn, Crabtree, Nicola, Ward, Kate, Tobias, Jon H

“…Context: Little is known of the relationships between muscle function and bone, based on the recently developed technique of jumping mechanography. Objective:…”
Get full text

Atypical psoriasis following rituximab for rheumatoid arthritis by Hardcastle, Sarah A, Gibbs, Sam, Williamson, Lyn

Get full text

Osteophytes, Enthesophytes, and High Bone Mass: A Bone‐Forming Triad With Potential Relevance in Osteoarthritis by Hardcastle, Sarah A., Dieppe, Paul, Gregson, Celia L., Arden, Nigel K., Spector, Tim D., Hart, Deborah J., Edwards, Mark H., Dennison, Elaine M., Cooper, Cyrus, Williams, Martin, Davey Smith, George, Tobias, Jon H.

“…Objective Previous studies of skeletal remains have suggested that both enthesophytes and osteophytes are manifestations of an underlying bone‐forming…”
Get full text

Dr. Hardcastle, et al reply by Hardcastle, Sarah A

Get full text

An online clinical decision tool to screen for vertebral fragility fractures (Vfrac) in older women presenting with back pain in general practice: protocol for a feasibility study in preparation for a future cluster randomised controlled trial by Khalid, Tanzeela Y., Peters, Tim J., Pocock, Lucy V., Drew, Sarah, Hardcastle, Sarah A., Paskins, Zoe, Davis, Sarah, Kariki, Eleni P., Clark, Emma M.

“…Summary This feasibility study for a future definitive randomized trial assesses the use and acceptability of a new clinical decision tool to identify risk of…”
Get full text

High bone mass is associated with an increased prevalence of joint replacement: a case-control study by Hardcastle, Sarah A, Gregson, Celia L, Deere, Kevin C, Davey Smith, George, Dieppe, Paul, Tobias, Jon H

“…Epidemiological studies have shown an association between OA and increased BMD. To explore the nature of this relationship, we examined whether the risk of OA…”
Get full text

E034 Rheumatology trainees’ experience of osteoporosis and metabolic bone disease: a UK-wide survey by Hardcastle, Sarah A, Rutter, Megan, Paskins, Zoe

Get full text

P138 Real-world incidence and management of hypocalcaemia after denosumab administration in patients with chronic kidney disease: a UK secondary-care based audit by Hardcastle, Sarah A, Alshakh, Randa, Webb, Jackie, Warren, Susan, Ahmed, Tehseen

Get full text

P140 Patient experience of osteoporosis telephone consultations by Webb, Jackie L, Hardcastle, Sarah A, Warren, Susie M, Hart, Darren J, Shipley, Jacqueline A, Ahmed, Tehseen

Get full text

087. PREGNANCY-ASSOCIATED OSTEOPOROSIS: A UK CASE SERIES by Yahya, Fariz, Hardcastle, Sarah A., Webb, Jackie, Bhalla, Ashok K.

Get full text

Atypical Psoriasis Following Rituximab for Rheumatoid Arthritis: Figure 1 by HARDCASTLE, SARAH A., GIBBS, SAM, WILLIAMSON, LYN

Get full text

O15. The Triad of Osteophytes, Enthesophytes and Increased Bone Mass May Help to Define a Bone-Forming Sub-Type of Osteoarthritis by Hardcastle, Sarah A., Dieppe, Paul, Gregson, Celia L., Arden, Nigel K., Spector, Tim D., Hart, Deborah, Edwards, Mark H., Dennison, Elaine, Cooper, Cyrus, Williams, Martin, Smith, George Davey, Tobias, Jon H.

Get full text

189. High Bone Mass is Associated with an Increased Prevalence of Radiographic Hip Osteoarthritis: A Case-Control Study by Hardcastle, Sarah A., Dieppe, Paul, Gregson, Celia L., Hunter, David, Thomas, Geraint, Arden, Nigel K., Spector, Tim D., Hart, Deborah J., Laugharne, Matthew J., Clague, Gavin A., Edwards, Mark H., Dennison, Elaine, Cooper, Cyrus, Williams, Martin, Davey Smith, George, Tobias, Jon H.

Get full text