Search Results - "Hard, Gordon C"

Critical review of renal tubule karyomegaly in non-clinical safety evaluation studies and its significance for human risk assessment by Hard, Gordon C.

“…Scientific databases were searched for terms applicable to karyomegaly in renal tubules of laboratory animals used in preclinical safety evaluation studies,…”
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Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System by Frazier, Kendall S., Seely, John Curtis, Hard, Gordon C., Betton, Graham, Burnett, Roger, Nakatsuji, Shunji, Nishikawa, Akiyoshi, Durchfeld-Meyer, Beate, Bube, Axel

“…The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of…”
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Confounders for kidney carcinogenesis in rodent cancer bioassays by Hard, Gordon C

“…In the long-term safety testing of chemicals for carcinogenicity the toxicologist needs to be aware of a number of scenarios where renal tubule tumors, or…”
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Some Aids to Histological Recognition of Hyaline Droplet Nephropathy in Ninety-Day Toxicity Studies by Hard, Gordon C.

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Ochratoxin A: 13-Week Oral Toxicity and Cell Proliferation in Male F344/N Rats by Rached, Eva, Hard, Gordon C., Blumbach, Kai, Weber, Klaus, Draheim, Regina, Lutz, Werner K., Özden, Sibel, Steger, Ulrich, Dekant, Wolfgang, Mally, Angela

“…Ochratoxin A (OTA) is nephrotoxic and a potent renal carcinogen. Male rats are most susceptible to OTA toxicity, and chronic administration of OTA (70 and 210…”
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Spontaneous Incidence of Oncocytic Proliferative Lesions in Control Rat Kidney by Hard, Gordon C., Seely, John Curtis, Betz, Laura J.

“…The spontaneous incidence of foci of oncocytic proliferation (oncocytic hyperplasia and oncocytoma) was assessed in a histopathological reevaluation of the…”
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Mechanisms of Rodent Renal Carcinogenesis Revisited by Hard, Gordon C.

“…The important renal tumors that can be induced by exposure of rats to chemical carcinogens are renal tubule tumors (RTTs) derived from tubule epithelium; renal…”
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Chemically Induced Renal Tubule Tumors in the Laboratory Rat and Mouse: Review of the NCI/NTP Database and Categorization of Renal Carcinogens Based on Mechanistic Information by Lock, Edward A., Hard, Gordon C.

“…ABSTRACT The incidence of renal tubule carcinogenesis in male and female rats or mice with 69 chemicals from the 513 bioassays conducted to date by the NCI/NTP…”
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Confounders for kidney carcinogenesis in rodent cancer bioassays by HARD, Gordon C

“…In the long-term safety testing of chemicals for carcinogenicity the toxicologist needs to be aware of a number of scenarios where renal tubule tumors, or…”
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A Data-Based Assessment of Alternative Strategies for Identification of Potential Human Cancer Hazards by Boobis, Alan R., Cohen, Samuel M., Doerrer, Nancy G., Galloway, Sheila M., Haley, Patrick J., Hard, Gordon C., Hess, Frederick G., Macdonald, James S., Thibault, Stéphane, Wolf, Douglas C., Wright, Jayne

“…The two-year cancer bioassay in rodents remains the primary testing strategy for in-life screening of compounds that might pose a potential cancer hazard. Yet…”
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Histological Investigation of Diagnostically Challenging Tubule Profiles in Advanced Chronic Progressive Nephropathy (CPN) in the Fischer 344 RaT by Hard, Gordon C., Seely, John Curtis

“…Recently, guidelines were suggested for discriminating proliferative-appearing tubule profiles encountered in advanced spontaneous chronic progressive…”
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Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin by Hard, Gordon C., Seely, John Curtis, Betz, Laura J., Hayashi, Shim-mo

“…Renal histopathology in the most recent 2-year carcinogenicity bioassay of quercetin, in Fischer 344 rats, was re-evaluated in an attempt to determine a mode…”
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Biotransformation and nephrotoxicity of ochratoxin B in rats by Mally, Angela, Keim-Heusler, Heike, Amberg, Alexander, Kurz, Michael, Zepnik, Herbert, Mantle, Peter, Völkel, Wolfgang, Hard, Gordon C., Dekant, Wolfgang

“…Ochratoxin B (OTB), a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin ochratoxin A (OTA), which is one of the…”
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Spontaneous Occurrence of a Distinctive Renal Tubule Tumor Phenotype in Rat Carcinogenicity Studies Conducted by the National Toxicology Program by Hard, Gordon C., Seely, John Curtis, Kissling, Grace E., Betz, Laura J.

“…The Toxicology Data Management System (TDMS) of the National Toxicology Program, National Institutes of Environmental Health Sciences, National Institutes of…”
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Chronic Progressive Nephropathy (CPN) in the Rat: Review of Pathology and Relationship to Renal Tumorigenesis by Seely, John Curtis, Hard, Gordon C.

“…Chronic progressive nephropathy (CPN) is a rodent-specific, age-related renal disease, particularly of male rats, characterized by a spectrum of distinct…”
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Corrigendum to “Histopathology re-examination of the NTP toxicity/carcinogenicity studies of tert-butyl alcohol to identify renal tumor and toxicity modes of action” [Regul. Toxicol. Pharmacol. 102 (2019) 65–73] by Hard, Gordon C., Cohen, Samuel M., Ma, Jihyun, Yu, Fang, Arnold, Lora L., Banton, Marcy I.

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Methyl-tert-butyl ether (MTBE): integration of rat and mouse carcinogenicity data with mode of action and human and rodent bioassay dosimetry and toxicokinetics indicates MTBE is not a plausible human carcinogen by Bus, James S., Gollapudi, B. Bhaskar, Hard, Gordon C.

“…Methyl-tert-butyl ether (MTBE) is a fuel oxygenate used in non-United States geographies. Multiple health reviews conclude that MTBE is not a human-relevant…”
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Renal Papillary Rarefaction: An Artifact Mimicking Papillary Necrosis by Seely, John Curtis, Francke, Sabine, Mog, Steven R., Frazier, Kendall S., Hard, Gordon C.

“…In histopathology, the presence of a tissue change that does not represent the tissue’s normal appearance can often lead to an incorrect diagnosis and…”
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A Survey of Mesenchyme-related Tumors of the Rat Kidney in the National Toxicology Program Archives, with Particular Reference to Renal Mesenchymal Tumor by Hard, Gordon C., Seely, John Curtis, Betz, Laura J.

“…In order to harmonize diagnostic terminology, confirm diagnostic criteria, and describe aspects of tumor biology characteristic of different tumor types, a…”
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Histopathology re-examination of the NTP toxicity/carcinogenicity studies of tert-butyl alcohol to identify renal tumor and toxicity modes of action by Hard, Gordon C., Cohen, Samuel M., Ma, Jihyun, Yu, Fang, Arnold, Lora L., Banton, Marcy I.

“…Tert-butyl alcohol (TBA) targets the rat kidney following repeated exposures, including renal tubule tumors. The mode of action (MOA) of these tumors,…”
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