Search Results - "Harbuz, Michael S"

Early-Life Exposure to Endotoxin Alters Hypothalamic-Pituitary-Adrenal Function and Predisposition to Inflammation by Shanks, Nola, Windle, Richard J., Perks, Paula A., Harbuz, Michael S., Jessop, David S., Ingram, Colin D., Lightman, Stafford L.

“…We have investigated whether exposure to Gram-negative bacterial endotoxin in early neonatal life can alter neuroendocrine and immune regulation in adult…”
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Hypothalamo-Pituitary-Adrenal Axis and Chronic Immune Activation by HARBUZ, MICHAEL S., CHOVER-GONZALEZ, ANJO J., JESSOP, DAVID S.

“…: Corticosteroids have potent immunosuppressive and anti‐inflammatory effects. Although corticosteroids are an important weapon in the clinical arsenal for…”
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Involvement and role of the hypothalamo-pituitary-adrenal (HPA) stress axis in animal models of chronic pain and inflammation by Bomholt, Signe F, Harbuz, Michael S, Blackburn-Munro, Gordon, Blackburn-Munro, Ruth E

“…Hypothalamo-pituitary-adrenal (HPA) axis changes have been reported in several disease states, including major depressive disorder, rheumatoid arthritis,…”
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The hypothalamo-pituitary-adrenal axis response to experimental traumatic brain injury by Grundy, P L, Harbuz, M S, Jessop, D S, Lightman, S L, Sharples, P M

“…Alterations in the hypothalamo-pituitary-adrenal (HPA) axis following traumatic brain injury have not been documented in detail. We used fluid percussion…”
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Differential regulation of proopiomelanocortin (POMC) mRNA expression in hypothalamus and anterior pituitary following repeated cyanamide with ethanol administration by Kinoshita, Hiroshi, Hishida, Shigeru, Ameno, Kiyoshi, Ijiri, Iwao, Harbuz, Michael S

“…We have investigated proopiomelanocortin (POMC) mRNA expression in the arcuate nucleus of the hypothalamus (ARC) and the anterior lobe of the pituitary (AL)…”
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Evidence that a single exposure to aversive stimuli triggers long-lasting effects in the hypothalamus-pituitary-adrenal axis that consolidate with time by Martí, O, García, A, Vallès, A, Harbuz, M S, Armario, A, Vellès, A

“…Because of its use as a negative reinforcer in animal studies and its potential pathological impact (e.g. post-traumatic stress disorder and depression),…”
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Orexin Expression and Function: Glucocorticoid Manipulation, Stress, and Feeding Studies by Ford, Gemma K, Al-Barazanji, Kamal A, Wilson, Shelagh, Jones, Declan N. C, Harbuz, Michael S, Jessop, David S

“…We investigated the effects of glucocorticoid manipulation on orexin-A-induced feeding and prepro-orexin mRNA levels in the lateral hypothalamic area (LHA) of…”
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Behavioral, neuroendocrine and neurochemical effects of the imidazoline I2 receptor selective ligand BU224 in naive rats and rats exposed to the stress of the forced swim test by FINN, David P, MARTI, Octavi, HUDSON, Alan L, HARBUZ, Michael S, VALLES, Astrid, BELDA, Xavier, MARQUEZ, Cristina, JESSOP, David S, LALIES, Margaret D, ARMARIO, Antonio, NUTT, David J

“…There is evidence for alterations in imidazoline(2) (I(2)) receptor density in depressed patients. Selective I(2) receptor ligands modulate central monoamine…”
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Opioid Peptides Endomorphin-1 and Endomorphin-2 in the Immune System in Humans and in a Rodent Model of Inflammation by JESSOP, DAVID S., RICHARDS, LOUISE J., HARBUZ, MICHAEL S.

“…: Endomorphin (EM)‐1 and EM‐2 are tetrapeptides with high affinity and selectivity for the μ‐opioid receptor. We have utilized specific radioimmunoassays to…”
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CRH in chronic inflammatory stress by Jessop, David S, Harbuz, Michael S, Lightman, Stafford L

“…Corticotropin-releasing hormone (CRH) is an important regulator of inflammation at the central level through hypothalamo-pituitary-adrenal (HPA) axis control…”
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Protective Effect of Prior Acute Immune Challenge, but Not Footshock, on Inflammation in the Rat by Harbuz, Michael S., Chover-Gonzalez, Anjo, Gibert-Rahola, Juan, Jessop, David S.

“…Previous studies have revealed that a single exposure to an acute stress or acute immune stimulus can produce long-lasting changes in the activity and…”
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HIGH ALCOHOL PREFERRING (HAP) AND LOW ALCOHOL PREFERRING (LAP) RATS SHOW ALTERED PROOPIOMELANOCORTIN (POMC) MESSENGER RNA EXPRESSION IN THE ARCUATE NUCLEUS by Kinoshita, Hiroshi, Harbuz, Michael S., Nishiguchi, Minori, Ouchi, Harumi, Minami, Takako, Utsumi, Takao, Motomura, Hiroyuki, Hishida, Shigeru

“…Aims and Methods: We have investigated proopiomelanocortin (POMC) and neuropeptide Y (NPY) gene expression in the arcuate nucleus of the hypothalamus comparing…”
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Glucocorticoids modulate BDNF mRNA expression in the rat hippocampus after traumatic brain injury by Grundy, Paul L, Patel, Nitin, Harbuz, Michael S, Lightman, Stafford L, Sharples, Peta M

“…Brain-derived neurotrophic factor (BDNF) expression in rat hippocampus is increased after experimental traumatic brain injury (TBI) and may be neuroprotective…”
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Glucocorticoids modulate the NGF mRNA response in the rat hippocampus after traumatic brain injury by Grundy, Paul L., Patel, Nitin, Harbuz, Michael S., Lightman, Stafford L., Sharples, Peta M.

“…Nerve growth factor (NGF) expression in the rat hippocampus is increased after experimental traumatic brain injury (TBI) and is neuroprotective…”
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Novel opioid peptides endomorphin-1 and endomorphin-2 are present in mammalian immune tissues by Jessop, David S, Major, Glenn N, Coventry, Toni L, Kaye, Sarah J, Fulford, Allison J, Harbuz, Michael S, De Bree, Freddy M

“…Endomorphin (EM)-1 and EM-2 are opioid tetrapeptides, reported within the central nervous system, which have very high specificity and affinity for the…”
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Acute ethanol decreases NPY mRNA but not POMC mRNA in the arcuate nucleus by Kinoshita, Hiroshi, Jessop, David S, Finn, David P, Coventry, Toni L, Roberts, David J, Ameno, Kiyoshi, Ijiri, Iwao, Harbuz, Michael S

“…The acute effects of ethanol and acetaldehyde on neuropeptide mRNA expression in the arcuate nucleus (ARC) was assessed. Acetaldehyde was increased in blood…”
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Brain-immune interactions in stress--the impact of hormones on disease by Jessop, David S, Harbuz, Michael S

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Acetaldehyde, a metabolite of ethanol, activates the hypothalamic–pituitary–adrenal axis in the rat by Kinoshita, Hiroshi, Jessop, David S., Finn, David P., Coventry, Toni L., Roberts, David J., Ameno, Kiyoshi, Jiri, Iwao, Harbuz, Michael S.

“…— Cyanamide is a potent inhibitor of aldehyde dehydrogenase (ALDH: EC 1.2.1.3) used in the treatment of alcoholics. In the presence of ethanol, cyanamide…”
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Activation of the hypothalamic-pituitary axis in adrenalectomised rats: potentiation by chronic stress by Martı́, Octavi, Harbuz, Michael S, Andrés, Rosa, Lightman, Stafford L, Armario, Antonio

“…The influence of chronic stress on the status of the hypothalamo-pituitary-adrenal (HPA) axis of sham-operated and adrenalectomised rats was assessed. Animals…”
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Nramp1 is expressed in neurons and is associated with behavioural and immune responses to stress by EVANS, Carlton A. W, HARBUZ, Michael S, OSTENFELD, Thor, NORRISH, Alan, BLACKWELL, Jenefer M

“…The gene Nramp1 encoding the natural resistance-associated macrophage protein (Nramp1) influences susceptibility to intracellular infections and autoimmune…”
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