Search Results - "Harbor, Phyllis C"
-
1
Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
Published in Oncogene (05-12-2002)“…Glioblastoma multiforme (GBM), the most common and malignant central nervous system tumor in humans, is highly proliferative and resistant to apoptosis. Stat3,…”
Get full text
Journal Article -
2
PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells
Published in Oncogene (10-11-2005)“…Glioblastoma multiforme (GBM) cells frequently harbor amplification and/or gain-of-function mutation of the EGFR gene leading to the activation of multiple…”
Get full text
Journal Article -
3
Identification of critical residues required for suppressor of cytokine signaling-specific regulation of interleukin-4 signaling
Published in The Journal of biological chemistry (25-08-2000)“…Suppressor of cytokine signaling (SOCS) family proteins were originally identified as cytokine-induced negative regulators of cytokine signaling. We show that…”
Get full text
Journal Article -
4
Serine phosphorylation of Stat6 negatively controls its DNA-binding function
Published in Journal of interferon & cytokine research (01-09-2005)“…In response to interleukin-4 (IL-4) or IL-13 stimulation of cells, Stat6 becomes phosphorylated on Tyr(641) and forms homodimers that migrate to the nucleus,…”
Get more information
Journal Article -
5
Identification of Critical Residues Required for Suppressor of Cytokine Signaling-specific Regulation of Interleukin-4 Signaling
Published in The Journal of biological chemistry (25-08-2000)“…Suppressor of cytokine signaling (SOCS) family proteins were originally identified as cytokine-induced negative regulators of cytokine signaling. We show that…”
Get full text
Journal Article -
6
-
7
IL-13R(alpha)2, a decoy receptor for IL-13 acts as an inhibitor of IL-4-dependent signal transduction in glioblastoma cells
Published in Cancer research (Chicago, Ill.) (15-02-2002)“…Interleukin (IL)-4 and IL-13 share the type II IL-4 receptor for cell signaling. We show that despite expressing the necessary signaling components,…”
Get full text
Journal Article