Search Results - "Harbison, Susan"

What have we learned about sleep from selective breeding strategies? by Harbison, Susan T

“…Abstract Selective breeding is a classic technique that enables an experimenter to modify a heritable target trait as desired. Direct selective breeding for…”
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Pinpointing the genetic and cellular links between sleep and metabolism by Harbison, Susan T

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Nonlinear expression patterns and multiple shifts in gene network interactions underlie robust phenotypic change in Drosophila melanogaster selected for night sleep duration by Souto-Maior, Caetano, Serrano Negron, Yazmin L, Harbison, Susan T

“…All but the simplest phenotypes are believed to result from interactions between two or more genes forming complex networks of gene regulation. Sleep is a…”
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Genome-wide association study of sleep in Drosophila melanogaster by Harbison, Susan T, McCoy, Lenovia J, Mackay, Trudy F C

“…Sleep is a highly conserved behavior, yet its duration and pattern vary extensively among species and between individuals within species. The genetic basis of…”
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Evolution of Reproductive Behavior by Anholt, Robert R H, O’Grady, Patrick, Wolfner, Mariana F, Harbison, Susan T

“…Abstract Behaviors associated with reproduction are major contributors to the evolutionary success of organisms and are subject to many evolutionary forces,…”
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Comparison of normalization and differential expression analyses using RNA-Seq data from 726 individual Drosophila melanogaster by Lin, Yanzhu, Golovnina, Kseniya, Chen, Zhen-Xia, Lee, Hang Noh, Negron, Yazmin L Serrano, Sultana, Hina, Oliver, Brian, Harbison, Susan T

“…A generally accepted approach to the analysis of RNA-Seq read count data does not yet exist. We sequenced the mRNA of 726 individuals from the Drosophila…”
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Selection for long and short sleep duration in Drosophila melanogaster reveals the complex genetic network underlying natural variation in sleep by Harbison, Susan T, Serrano Negron, Yazmin L, Hansen, Nancy F, Lobell, Amanda S

“…Why do some individuals need more sleep than others? Forward mutagenesis screens in flies using engineered mutations have established a clear genetic component…”
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Genome-wide association in Drosophila identifies a role for Piezo and Proc-R in sleep latency by Eiman, Matthew N., Kumar, Shailesh, Serrano Negron, Yazmin L., Tansey, Terry R., Harbison, Susan T.

“…Sleep latency, the amount of time that it takes an individual to fall asleep, is a key indicator of sleep need. Sleep latency varies considerably both among…”
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Natural selection on sleep duration in Drosophila melanogaster by Souto-Maior, Caetano, Serrano Negron, Yazmin L., Harbison, Susan T.

“…Sleep is ubiquitous across animal species, but why it persists is not well understood. Here we observe natural selection act on Drosophila sleep by relaxing…”
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Identification of Genes Contributing to a Long Circadian Period in Drosophila Melanogaster by Kumar, Shailesh, Tunc, Ilker, Tansey, Terry R., Pirooznia, Mehdi, Harbison, Susan T.

“…The endogenous circadian period of animals and humans is typically very close to 24 h. Individuals with much longer circadian periods have been observed,…”
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Natural genetic variation in a dopamine receptor is associated with variation in female fertility in Drosophila melanogaster by Lyman, Richard F, Lyman, Rachel A, Yamamoto, Akihiko, Huang, Wen, Harbison, Susan T, Zhou, Shanshan, Anholt, Robert R H, Mackay, Trudy F C

“…Fertility is a major component of fitness but its genetic architecture remains poorly understood. Using a full diallel cross of 50 Genetic Reference Panel…”
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Spontaneous mutations and the origin and maintenance of quantitative genetic variation by Huang, Wen, Lyman, Richard F, Lyman, Rachel A, Carbone, Mary Anna, Harbison, Susan T, Magwire, Michael M, Mackay, Trudy Fc

“…Mutation and natural selection shape the genetic variation in natural populations. Here, we directly estimated the spontaneous mutation rate by sequencing new…”
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Genotype Influences Day-to-Day Variability in Sleep in Drosophila melanogaster by Wu, Katherine J, Kumar, Shailesh, Serrano Negron, Yazmin L, Harbison, Susan T

“…Patterns of sleep often vary among individuals. But sleep and activity may also vary within an individual, fluctuating in pattern across time. One possibility…”
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Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster by Harbison, Susan T., Kumar, Shailesh, Huang, Wen, McCoy, Lenovia J., Smith, Kirklin R., Mackay, Trudy F. C.

“…Circadian rhythms influence physiological processes from sleep–wake cycles to body temperature and are controlled by highly conserved cycling molecules…”
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Knockdown expression of Syndecan in the fat body impacts nutrient metabolism and the organismal response to environmental stresses in Drosophila melanogaster by Eveland, Matthew, Brokamp, Gabrielle A., Lue, Chia-Hua, Harbison, Susan T., Leips, Jeff, De Luca, Maria

“…The heparan sulfate proteoglycan syndecans are transmembrane proteins involved in multiple physiological processes, including cell-matrix adhesion and…”
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Microenvironmental Gene Expression Plasticity Among Individual Drosophila melanogaster by Lin, Yanzhu, Chen, Zhen-Xia, Oliver, Brian, Harbison, Susan T

“…Differences in phenotype among genetically identical individuals exposed to the same environmental condition are often noted in genetic studies. Despite this…”
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A conserved role for frizzled in sleep architecture by Gessner, Nicholas R, Peiravi, Morteza, Zhang, Fan, Yimam, Shemsiya, Springer, Danielle, Harbison, Susan T

“…Abstract Previous studies of natural variants in Drosophila melanogaster implicated the Wnt signaling receptor frizzled in sleep. Given that the Wnt signaling…”
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Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep by Mackay, Trudy F C, Harbison, Susan T, Carbone, Mary Anna, Ayroles, Julien F, Stone, Eric A, Lyman, Richard F

“…Sleep disorders are common in humans, and sleep loss increases the risk of obesity and diabetes. Studies in Drosophila have revealed molecular pathways and…”
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The Sleep Inbred Panel, a Collection of Inbred Drosophila melanogaster with Extreme Long and Short Sleep Duration by Serrano Negron, Yazmin L, Hansen, Nancy F, Harbison, Susan T

“…Understanding how genomic variation causes differences in observable phenotypes remains a major challenge in biology. It is difficult to trace the sequence of…”
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Energy stores are not altered by long-term partial sleep deprivation in Drosophila melanogaster by Harbison, Susan T, Sehgal, Amita

“…Recent human studies reveal a widespread association between short sleep and obesity. Two hypotheses, which are not mutually exclusive, might explain this…”
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