Search Results - "Harbauer, Angelika B."

The Protein Import Machinery of Mitochondria—A Regulatory Hub in Metabolism, Stress, and Disease by Harbauer, Angelika B., Zahedi, René P., Sickmann, Albert, Pfanner, Nikolaus, Meisinger, Chris

“…Mitochondria fulfill central functions in bioenergetics, metabolism, and apoptosis. They import more than 1,000 different proteins from the cytosol. It had…”
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Cell cycle–dependent regulation of mitochondrial preprotein translocase by Harbauer, Angelika B., Opalińska, Magdalena, Gerbeth, Carolin, Herman, Josip S., Rao, Sanjana, Schönfisch, Birgit, Guiard, Bernard, Schmidt, Oliver, Pfanner, Nikolaus, Meisinger, Chris

“…Mitochondria play central roles in cellular energy conversion, metabolism, and apoptosis. Mitochondria import more than 1000 different proteins from the…”
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Glucose-Induced Regulation of Protein Import Receptor Tom22 by Cytosolic and Mitochondria-Bound Kinases by Gerbeth, Carolin, Schmidt, Oliver, Rao, Sanjana, Harbauer, Angelika B., Mikropoulou, Despina, Opalińska, Magdalena, Guiard, Bernard, Pfanner, Nikolaus, Meisinger, Chris

“…Most mitochondrial proteins are imported by the translocase of the outer mitochondrial membrane (TOM). Tom22 functions as central receptor and transfers…”
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Regulation of Mitochondrial Protein Import by Cytosolic Kinases by Schmidt, Oliver, Harbauer, Angelika B., Rao, Sanjana, Eyrich, Beate, Zahedi, René P., Stojanovski, Diana, Schönfisch, Birgit, Guiard, Bernard, Sickmann, Albert, Pfanner, Nikolaus, Meisinger, Chris

“…Mitochondria import a large number of nuclear-encoded proteins via membrane-bound transport machineries; however, little is known about regulation of the…”
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Biogenesis of the preprotein translocase of the outer mitochondrial membrane: protein kinase A phosphorylates the precursor of Tom40 and impairs its import by Rao, Sanjana, Schmidt, Oliver, Harbauer, Angelika B, Schönfisch, Birgit, Guiard, Bernard, Pfanner, Nikolaus, Meisinger, Chris

“…The preprotein translocase of the outer mitochondrial membrane (TOM) functions as the main entry gate for the import of nuclear-encoded proteins into…”
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Mitochondrial Phenotypes in Parkinson's Diseases-A Focus on Human iPSC-Derived Dopaminergic Neurons by Heger, Leonie M, Wise, Rachel M, Hees, J Tabitha, Harbauer, Angelika B, Burbulla, Lena F

“…Established disease models have helped unravel the mechanistic underpinnings of pathological phenotypes in Parkinson's disease (PD), the second most common…”
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Mitochondrial health maintenance in axons by Harbauer, Angelika B

“…Neurons are post-mitotic cells that must function throughout the life of an organism. The high energetic requirements and Ca spikes of synaptic transmission…”
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Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy by Harbauer, Angelika B., Hees, J. Tabitha, Wanderoy, Simone, Segura, Inmaculada, Gibbs, Whitney, Cheng, Yiming, Ordonez, Martha, Cai, Zerong, Cartoni, Romain, Ashrafi, Ghazaleh, Wang, Chen, Perocchi, Fabiana, He, Zhigang, Schwarz, Thomas L.

“…PTEN-induced kinase 1 (PINK1) is a short-lived protein required for the removal of damaged mitochondria through Parkin translocation and mitophagy. Because the…”
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Analysis of Mitochondria by Single-Organelle Resolution by Harbauer, Angelika B, Schneider, Annika, Wohlleber, Dirk

“…Cellular organelles are highly specialized compartments with distinct functions. With the increasing resolution of detection methods, it is becoming clearer…”
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Mitochondrial hitch-hiking of Pink1 mRNA supports axonal mitophagy by Harbauer, Angelika B., Schwarz, Thomas L.

“…Mitostasis, the process of mitochondrial maintenance by biogenesis and degradative mechanisms, is challenged by the extreme length of axons. PINK1 (PTEN…”
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Fluorogenic Chemical Probes for Wash-free Imaging of Cell Membrane Damage in Ferroptosis, Necrosis, and Axon Injury by Mauker, Philipp, Beckmann, Daniela, Kitowski, Annabel, Heise, Constanze, Wientjens, Chantal, Davidson, Andrew J., Wanderoy, Simone, Fabre, Gabin, Harbauer, Angelika B., Wood, Will, Wilhelm, Christoph, Thorn-Seshold, Julia, Misgeld, Thomas, Kerschensteiner, Martin, Thorn-Seshold, Oliver

“…Selectively labeling cells with damaged membranes is needed not only for identifying dead cells in culture, but also for imaging membrane barrier dysfunction…”
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In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy by Kravic, Bojana, Harbauer, Angelika B., Romanello, Vanina, Simeone, Luca, Vögtle, F.-Nora, Kaiser, Tobias, Straubinger, Marion, Huraskin, Danyil, Böttcher, Martin, Cerqua, Cristina, Martin, Eva Denise, Poveda-Huertes, Daniel, Buttgereit, Andreas, Rabalski, Adam J., Heuss, Dieter, Rudolf, Rüdiger, Friedrich, Oliver, Litchfield, David, Marber, Michael, Salviati, Leonardo, Mougiakakos, Dimitrios, Neuhuber, Winfried, Sandri, Marco, Meisinger, Chris, Hashemolhosseini, Said

“…In yeast, Tom22, the central component of the TOMM (translocase of outer mitochondrial membrane) receptor complex, is responsible for the recognition and…”
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Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons by Hees, J. Tabitha, Wanderoy, Simone, Lindner, Jana, Helms, Marlena, Murali Mahadevan, Hariharan, Harbauer, Angelika B.

“…Mitochondrial quality control failure is frequently observed in neurodegenerative diseases. The detection of damaged mitochondria by stabilization of…”
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Live-Cell Imaging of RNA Transport in Axons of Cultured Primary Neurons by Hees, J Tabitha, Harbauer, Angelika B

“…The use of fluorescent proteins has revolutionized the study of protein localization and transport. However, the visualization of other molecules and…”
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Per Anhalter ins Axon: Neuronale Mitochondrien transportieren mRNA by Rühmkorf, Alina, Harbauer, Angelika B.

“…Local translation of mRNAs supports the survival and identity of the axonal and dendritic neuronal sub-compartments. Interestingly, one of the largest…”
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Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD–associated UBQLN2 mutants by Strohm, Laura, Hu, Zehan, Suk, Yongwon, Rühmkorf, Alina, Sternburg, Erin, Gattringer, Vanessa, Riemenschneider, Henrick, Berutti, Riccardo, Graf, Elisabeth, Weishaupt, Jochen H, Brill, Monika S, Harbauer, Angelika B, Dormann, Dorothee, Dengjel, Jörn, Edbauer, Dieter, Behrends, Christian

“…Ubiquilin-2 (UBQLN2) is a ubiquitin-binding protein that shuttles ubiquitinated proteins to proteasomal and autophagic degradation. UBQLN2 mutations are…”
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Per Anhalter ins Axon: Neuronale Mitochondrien transportieren mRNA by Rühmkorf, Alina, Harbauer, Angelika B.

“…Abstract Local translation of mRNAs supports the survival and identity of the axonal and dendritic neuronal sub-compartments. Interestingly, one of the largest…”
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AMPK and insulin control the switch between mitochondrial hitchhiking of Pink1 mRNA and mitophagy in neurons

“…AMPK directly phosphorylates the mitochondrial protein SYNJ2BP to facilitate its interaction with the RNA-binding protein SYNJ2a, which transports Pink1 mRNA…”
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Mitochondria. Cell cycle-dependent regulation of mitochondrial preprotein translocase by Harbauer, Angelika B, Opalińska, Magdalena, Gerbeth, Carolin, Herman, Josip S, Rao, Sanjana, Schönfisch, Birgit, Guiard, Bernard, Schmidt, Oliver, Pfanner, Nikolaus, Meisinger, Chris

“…Mitochondria play central roles in cellular energy conversion, metabolism, and apoptosis. Mitochondria import more than 1000 different proteins from the…”
Get full text