In vitro evaluation of the anti-proliferative activities of the wood essential oils of three Cedrus species against K562 human chronic myelogenous leukaemia cells

In vitro evaluation of the anti-proliferative activities of the wood essential oils of three Cedrus species against K562 human chronic myelogenous leukaemia cells

There are four kinds of Cedar: Cedrus libani naturally occurring in Lebanon, Syria and Turkey, Cedrus atlantica in Morocco and Algeria, Cedrus brevefolia in Cyprus Island and Cedrus deodara which is distributed in Himalayan Mountains. Wood essential oils obtained from C. libani, C. atlantica and C....

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Bibliographic Details
Published in:Natural product research Vol. 26; no. 23; pp. 2227 - 2231
Main Authors: Saab, Antoine M., Lampronti, Ilaria, Borgatti, Monica, Finotti, Alessia, Harb, Faouzi, Safi, Samir, Gambari, Roberto
Format: Journal Article
Language:English
Published: England Taylor & Francis Group 01-01-2012
Subjects:
Antineoplastic Agents, Phytogenic - pharmacology
antiproliferative activity
Cedrus - chemistry
Cedrus atlantica
Cedrus deodara
Cedrus libani
Cell Differentiation - drug effects
Cell Proliferation - drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
GC/MS
Humans
Inhibitory Concentration 50
K562 Cells - drug effects
Oils, Volatile - pharmacology
terpenes
Wood - chemistry
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Summary:There are four kinds of Cedar: Cedrus libani naturally occurring in Lebanon, Syria and Turkey, Cedrus atlantica in Morocco and Algeria, Cedrus brevefolia in Cyprus Island and Cedrus deodara which is distributed in Himalayan Mountains. Wood essential oils obtained from C. libani, C. atlantica and C. deodara were tested for the inhibition of K562 cell proliferation and for the induction of erythroid differentiation. The wood essential oils of C. libani, C. atlantica and C. deodara inhibited the proliferation of the K562 cell line exhibiting IC 50 values 23.38 ± 1.7, 59.37 ± 2.6 and 37.09 ± 1.4 µg mL −1 , respectively. Meanwhile, C. libani wood oils induced a percentage of erythroid differentiation of 15 ± 2% at concentration 5 µg mL −1 . Cedrus deodara wood oil indicated a percentage of erythroid differentiation of 20 ± 2% at concentration 25 µg mL −1 and C. atlantica wood oils showed a percentage of erythroid differentiation of 12 ± 1.8% at concentration 10 µg mL −1 .
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content type line 23
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2011.643885