Search Results - "Harats, D"

The effect of α-linolenic acid enrichment in perinatal diets in preventing high fat diet-induced SCD1 increased activity and lipid disarray in adult offspring of low density lipoprotein receptor knockout (LDLRKO) mice by Leikin-Frenkel, A., Cohen, H., Keshet, R., Shnerb-GanOr, R., Kandel-Kfir, M., Harari, A., Hollander, K.S., Shaish, A., Harats, D., Kamari, Y.

“…•ALA (n-3 α- linolenic acid) dietary enrichment during pregnancy-lactation, protects the adult LDLRKO mice offspring from HFD-induced lipid disarray.•ALA…”
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Nifedipine Treatment for Hypertension is Associated with Enhanced Lipolytic Activity and Accelerated Clearance of Postprandial Lipemia by Grosskopf, I, Shaish, A, Charach, G, Harats, D, Kamari, Y

“…Hypertension, advanced age, postprandial hyperlipidemia, and insulin resistance are major risk factors for atherosclerosis. The calcium channel blocker…”
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Cardiovascular risk assessment and carotid intima-media thickness in young adults, survivors of Hodgkin's lymphoma by Cohen, H, Bitzur, R, Shechter, M, Harats, D, Modan, D

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VB‐201, an oxidized phospholipid small molecule, inhibits CD14‐ and Toll‐like receptor‐2‐dependent innate cell activation and constrains atherosclerosis by Mendel, I., Feige, E., Yacov, N., Salem, Y., Levi, I., Propheta‐Meiran, O., Shoham, A., Ishai, E., George, J., Harats, D., Breitbart, E.

“…Summary Atherosclerosis is an inflammatory disease of the vascular wall. Activated monocytes and dendritic cells (DC) in the intima layer of the vasculature…”
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The Effect of Klotho Treatment on Atherogenesis, Blood Pressure, and Metabolic Parameters in Experimental Rodent Models by Kamari, Y, Fingrut, O, Shaish, A, Almog, T, Kandel-Kfir, M, Harats, D, Rubinek, T, Wolf, I

“…Klotho is a transmembrane protein, expressed mainly in the kidneys and the choroid plexus. The extracellular domain of klotho is composed of 2 internal…”
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P1311 REDUCED HEPATIC INJURY IN BOTH IL1α AND IL1β DEFICIENT MICE FOLLOWING D-GALACTOSAMINE/LIPOPOLYSACCHARIDE-INDUCED FULMINANT HEPATIC FAILURE by Sultan, M, Safran, M, Lahat, E, Harats, D, Kamari, Y, Ben-Ari, Z

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Thrombophilic factors are not the leading cause of thrombosis in Behçet’s disease by Leiba, M, Seligsohn, U, Sidi, Y, Harats, D, Sela, B A, Griffin, J H, Livneh, A, Rosenberg, N, Gelernter, I, Gur, H, Ehrenfeld, M

“…Background: Venous and arterial thromboses occur in patients with Behçet’s disease and are associated with significant morbidity and mortality. Studies on a…”
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2901 Phase 2 study of VB-, an anti-cancer gene therapy, as monotherapy followed by combination of VB-111 with bevacizumab, in patients with recurrent glioblastoma by Brenner, A, Cohen, Y, Vredenburgh, J, Peters, K, Nayak, L, Blumenthal, D, Bokstein, F, Breitbart, E, Bangio, L, Sher, N, Harats, D, Wen, P

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The Ubiquitin-Proteasome Pathway Mediates the Regulated Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase by Ravid, Tommer, Doolman, Ram, Avner, Rachel, Harats, Dror, Roitelman, Joseph

“…3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR), the key regulatory enzyme in the mevalonate (MVA) pathway, is rapidly degraded in mammalian cells…”
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Antitumor Activity of VB-111, a Novel Antiangiogenic Virotherapeutic, in Thyroid Cancer Xenograft Mouse Models by Reddi, H V, Madde, P, Cohen, Y C, Bangio, L, Breitbart, E, Harats, D, Bible, K C, Eberhardt, N L

“…VB-111 is an engineered antiangiogenic adenovirus that expresses Fas-c in angiogenic blood vessels and has previously been shown to have significant antitumor…”
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Hypoxia-inducible factor-1α (HIF-1α) overexpression induces preeclampsia-like manifestations in pregnant mice by Tal, R, Shaish, A, Barshack, I, Polak-Charcon, S, Afek, A, Harats, D

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Patients with Glanzmann thrombasthenia lacking platelet glycoprotein αIIbβ3 (GPIIb/IIIa) and αvβ3 receptors are not protected from atherosclerosis by SHPILBERG, O, RABI, I, SCHILLER, K, WALDEN, R, HARATS, D, TYRRELL, K. S, COLLER, B, SELIGSOHN, U

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Rosiglitazone (PPARγ-agonist) attenuates atherogenesis with no effect on hyperglycaemia in a combined diabetes-atherosclerosis mouse model by Levi, Z., Shaish, A., Yacov, N., Levkovitz, H., Trestman, S., Gerber, Y., Cohen, H., Dvir, A., Rhachmani, R., Ravid, M., Harats, D.

“…Background: The administration of peroxisome proliferator‐activated receptor γ (PPARγ) agonists to low‐density lipoprotein (LDL)‐receptor‐deficient mice…”
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LDL receptor deficiency unmasks altered VLDL triglyceride metabolism in VLDL receptor transgenic and knockout mice by Tacken, P J, Teusink, B, Jong, M C, Harats, D, Havekes, L M, van Dijk, K W, Hofker, M H

“…The very low density lipoprotein receptor (VLDLR) has been proposed to play a role in the delivery of fatty acids to peripheral tissues. However, despite…”
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Citrus fruit supplementation reduces lipoprotein oxidation in young men ingesting a diet high in saturated fat: presumptive evidence for an interaction between vitamins C and E in vivo by Harats, D, Chevion, S, Nahir, M, Norman, Y, Sagee, O, Berry, EM

“…To determine the effects of vitamin C on cardiovascular risk factors, we studied dietary vitamin C enrichment in 36 healthy male students consuming a diet high…”
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Autoantibodies associated with atherosclerosis by Shoenfeld, Y, Sherer, Y, George, J, Harats, D

“…Atherosclerosis is a multifactorial pathological process. In recent years, the immune factors associated with its initiation and progression have been…”
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Tissue-specific gene therapy directed to tumor angiogenesis by VARDA-BLOOM, N, SHAISH, A, KOPOLOVITC, Y, HARATS, D, GONEN, A, LEVANON, K, GREENBEREGER, S, FERBER, S, LEVKOVITZ, H, CASTEL, D, GOLDBERG, I, AFEK, A

“…Gene therapy directed specifically to the vascular wall, particularly to angiogenic endothelial cells is a prerequisite in vascular disease treatment…”
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Autoimmunity in atherosclerosis: lessons from experimental models by George, J, Afek, A, Gilburd, B, Harats, D, Shoenfeld, Y

“…The modern view of atherosclerosis is of a chronic inflammatory disorder. In accord with this paradigm, the process of uninhibited influx of fat to the vessel…”
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Atherosclerosis-related markers in systemic lupus erythematosus patients: The role of humoral immunity in enhanced atherogenesis by George, J, Harats, D, Gilburd, B, Levy, Y, Langevitz, P, Shoenfeld, Y

“…Systemic Lupus Erythematosus (SLE) patients experience premature atherosclerosis. A deranged lipid metabolism and use of immunosuppressive medications accounts…”
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Antiangiogenic systemic gene therapy combined with doxorubicin administration induced caspase 8 and 9-mediated apoptosis in endothelial cells and an anti-metastasis effect by Peled, M, Shaish, A, Greenberger, S, Katav, A, Hodish, I, Ben-Shushan, D, Barshack, I, Mendel, I, Frishman, L, Tal, R, Bangio, L, Breitbart, E, Harats, D

“…Ad-PPE-Fas-c is an adenovector that expresses Fas-c under the control of the modified pre-proendothelin-1 (PPE-1) promoter. Fas-c is a chimeric death receptor…”
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