Search Results - "Harari, Olivier A"

Pozelimab for CHAPLE disease: results from in-trial interviews and clinical outcome assessments by Litcher-Kelly, Leighann, Ozen, Ahmet, Ollis, Sarah, Feldman, Hagit Baris, Yaworsky, Andrew, Medrano, Paolo, Chongsrisawa, Voranush, Brackin, Taylor, Perlee, Lorah, Walker, Marisa, Pradeep, Sharanya, Lenardo, Michael J, Harari, Olivier A, Jalbert, Jessica J

“…CD55 deficiency with hyper-activation of complement, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE) disease is ultra-rare (< 100 children or…”
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NF-κB and innate immunity in ischemic stroke by Harari, Olivier A., Liao, James K.

“…Acute cerebral ischemia elicits an innate immune response that leads to a cascade of events that culminates in necrotic death of neurons and injury to their…”
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First‐in‐human randomized study of bimekizumab, a humanized monoclonal antibody and selective dual inhibitor of IL‐17A and IL‐17F, in mild psoriasis by Glatt, Sophie, Helmer, Eric, Haier, Birgit, Strimenopoulou, Foteini, Price, Graham, Vajjah, Pavan, Harari, Olivier A., Lambert, John, Shaw, Stevan

“…Aims To assess safety, pharmacokinetics (PK) and clinical efficacy of bimekizumab (formerly UCB4940), a novel humanized monoclonal antibody and dual inhibitor…”
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Evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy disease: an open-label phase 2 and 3 study by Ozen, Ahmet, Chongsrisawat, Voranush, Sefer, Asena Pinar, Kolukisa, Burcu, Jalbert, Jessica J, Meagher, Karoline A, Brackin, Taylor, Feldman, Hagit Baris, Baris, Safa, Karakoc-Aydiner, Elif, Ergelen, Rabia, Fuss, Ivan J, Moorman, Heather, Suratannon, Narissara, Suphapeetiporn, Kanya, Perlee, Lorah, Harari, Olivier A, Yancopoulos, George D, Lenardo, Michael J, Miller, Jutta L., Eshach Adiv, Orly, Bilgic Eltan, Sevgi, Yorgun Altunbas, Melek, Magliocco, Mary, Matthews, Helen, Marciano, Beatriz E., Chatchatee, Pantipa, Trbovic, Caryn F., Burczynski, Michael E., Chaudhari, Umesh, Usta, Yusuf, Altuntaş, Cansu, Yavuz, Sibel, Baştürk, Ahmet, Demirbaş Ar, Fatma, Topal, Erdem, Kalaycı, Ayhan Gazi, Weerapakorn, Wanlapa, Calabi Martínez, Ana Andrea, Bottero, Adriana

“…CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE) is an ultra-rare genetic disorder…”
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Chronic inflammation and coronary microvascular dysfunction in patients without risk factors for coronary artery disease by Recio-Mayoral, Alejandro, Mason, Justin C., Kaski, Juan C., Rubens, Michael B., Harari, Olivier A., Camici, Paolo G.

“…Aims To demonstrate that exposure to chronic inflammation results in coronary microvascular dysfunction (CMD). Methods and results Using positron emission…”
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Endothelial Cell E- and P-Selectin Up-Regulation in Murine Contact Sensitivity Is Prolonged by Distinct Mechanisms Occurring in Sequence by Harari, Olivier A, McHale, Julie F, Marshall, Diane, Ahmed, Saifur, Brown, Derek, Askenase, Philip W, Haskard, Dorian O

“…The selectins are adhesion molecules that mediate the tethering and rolling of leukocytes on vascular endothelium. Although E-selectin and P-selectin are known…”
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18F-fluorodeoxyglucose-positron emission tomography imaging in idiopathic inflammatory myositis by Harari, Olivier A, Al-Nahhas, Adil, Jawad, Ali

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A Protein Kinase Cε-Anti-apoptotic Kinase Signaling Complex Protects Human Vascular Endothelial Cells against Apoptosis through Induction of Bcl-2 by Steinberg, Rivka, Harari, Olivier A., Lidington, Elaine A., Boyle, Joseph J., Nohadani, Mahrokh, Samarel, Allen M., Ohba, Motoi, Haskard, Dorian O., Mason, Justin C.

“…Endothelial cell apoptosis is associated with vascular injury and predisposes to atherogenesis. Endothelial cells express anti-apoptotic genes including Bcl-2,…”
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Absence of TRAM Restricts Toll-Like Receptor 4 Signaling in Vascular Endothelial Cells to the MyD88 Pathway by Harari, Olivier A, Alcaide, Pilar, Ahl, Daniela, Luscinskas, F William, Liao, James K

“…Mammalian cells respond to bacterial lipopolysaccharide (LPS) through a cognate receptorToll-like receptor 4 (TLR4). The signaling pathways, which link TLR4 to…”
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25 A phase 2/3 study evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE disease) by Ozen, Ahmet, Chongsrisawat, Voranush, Pinar Sefer, Asena, Kolukisa, Burcu, Jalbert, Jessica J., Miller, Jutta L., Meagher, Karoline A., Brackin, Taylor, Feldman, Hagit Baris, Adiv, Orly Eshach, Baris, Safa, Karakoc-Aydiner, Elif, Eltan, Sevgi Bilgic, Altunbaş, Melek Yorgun, Ergelen, Rabia, Fuss, Ivan J., Moorman, Heather, Magliocco, Mary, Matthews, Helen, Marciano, Beatriz E., Suratannon, Narissara, Chatchatee, Pantipa, Suphapeetiporn, Kanya, Trbovic, Caryn F., Burczynski, Michael E., Chaudhari, Umesh, Perlee, Lorah, Harari, Olivier A., Lenardo, Michael J.

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NF-[kappa]B and innate immunity in ischemic stroke by Harari, Olivier A, Liao, James K

“…Acute cerebral ischemia elicits an innate immune response that leads to a cascade of events that culminates in necrotic death of neurons and injury to their…”
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Abstract 6133: Microvascular Dysfunction and Chronic Inflammation in Patients without Cardiovascular Risk Factors by Recio-Mayoral, Alejandro, Mason, Justin C, Kaski, Juan C, Rubens, Michael B, Harari, Olivier A, Camici, Paolo G

“…Abstract only Premature coronary atherosclerosis, which is actually seen as an active inflammatory process, is an established complication of systemic…”
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TNF-alpha and IL-1 sequentially induce endothelial ICAM-1 and VCAM-1 expression in MRL/lpr lupus-prone mice by McHale, J F, Harari, O A, Marshall, D, Haskard, D O

“…Dysfunctional leukocyte-endothelial interactions are thought to play a key role in systemic lupus erythematosus pathogenesis. We questioned the importance of…”
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Vascular endothelial cell expression of ICAM-1 and VCAM-1 at the onset of eliciting contact hypersensitivity in mice: evidence for a dominant role of TNF-alpha by McHale, J F, Harari, O A, Marshall, D, Haskard, D O

“…We have studied vascular endothelial activation and increased expression of ICAM-1 and VCAM-1 at the onset of the elicitation phase of oxazolone contact…”
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A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2 by Steinberg, Rivka, Harari, Olivier A, Lidington, Elaine A, Boyle, Joseph J, Nohadani, Mahrokh, Samarel, Allen M, Ohba, Motoi, Haskard, Dorian O, Mason, Justin C

“…Endothelial cell apoptosis is associated with vascular injury and predisposes to atherogenesis. Endothelial cells express anti-apoptotic genes including Bcl-2,…”
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A Protein Kinase Cϵ-Anti-apoptotic Kinase Signaling Complex Protects Human Vascular Endothelial Cells against Apoptosis through Induction of Bcl-2 by Rivka Steinberg, Olivier A. Harari, Elaine A. Lidington, Joseph J. Boyle, Mahrokh Nohadani, Allen M. Samarel, Motoi Ohba, Dorian O. Haskard, Justin C. Mason

“…Endothelial cell apoptosis is associated with vascular injury and predisposes to atherogenesis. Endothelial cells express anti-apoptotic genes including Bcl-2,…”
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TNF-alpha, IL-4, and IFN-gamma regulate differential expression of P- and E-selectin expression by porcine aortic endothelial cells by Stocker, C J, Sugars, K L, Harari, O A, Landis, R C, Morley, B J, Haskard, D O

“…P- and E-selectin are surface glycoproteins that mediate leukocyte rolling on the surface of endothelium in inflammation. We have cloned porcine P-selectin…”
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TNF-{alpha} and IL-1 Sequentially Induce Endothelial ICAM-1 and VCAM-1 Expression in MRL/lpr Lupus-Prone Mice by McHale, Julie F, Harari, Olivier A, Marshall, Diane, Haskard, Dorian O

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Vascular Endothelial Cell Expression of ICAM-1 and VCAM-1 at the Onset of Eliciting Contact Hypersensitivity in Mice: Evidence for a Dominant Role of TNF-{alpha} by McHale, Julie F, Harari, Olivier A, Marshall, Diane, Haskard, Dorian O

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TNF-{alpha}, IL-4, and IFN-{gamma} Regulate Differential Expression of P- and E-Selectin Expression by Porcine Aortic Endothelial Cells by Stocker, Claire J, Sugars, Katharine L, Harari, Olivier A, Landis, R. Clive, Morley, Bernard J, Haskard, Dorian O

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