Search Results - "Harapanhalli, Ravi"

Vorinostat for Treatment of Cutaneous Manifestations of Advanced Primary Cutaneous T-Cell Lymphoma by MANN, Bhupinder S, JOHNSON, John R, HARAPANHALLI, Ravi S, DAGHER, Ramzi, FARRELL, Ann, JUSTICE, Robert, PAZDUR, Richard, KUN HE, SRIDHARA, Rajeshwari, ABRAHAM, Sophia, BOOTH, Brian P, VERBOIS, Leigh, MORSE, David E, JEE, Josephine M, POPE, Sarah

“…Purpose: To discuss vorinostat approval for treatment of cutaneous manifestations of advanced cutaneous T-cell lymphoma (CTCL). Experimental Design: Data from…”
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Sprycel for Chronic Myeloid Leukemia and Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia Resistant to or Intolerant of Imatinib Mesylate by BRAVE, Michael, GOODMAN, Vicki, MEN, Angela, NOORY, Carol, RAMCHANDANI, Roshni, KENNA, Leslie, BOOTH, Brian, GOBBURU, Joga, XIAOPING JIANG, SRIDHARA, Rajeshwari, JUSTICE, Robert, PAZDUR, Richard, KAMINSKAS, Edvardas, FARRELL, Ann, TIMMER, William, POPE, Sarah, HARAPANHALLI, Ravi, SABER, Haleh, MORSE, David, BULLOCK, Julie

“…Purpose: On June 28, 2006, the U.S. Food and Drug Administration approved dasatinib (Sprycel; Bristol-Myers Squibb), a new small-molecule inhibitor of multiple…”
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Food and Drug Administration Requirements for Testing and Approval of New Radiopharmaceuticals by Harapanhalli, Ravi S., PhD

“…In March 2004, the Food and Drug Administration (FDA) published a report entitled Challenge and Opportunity on the Critical Path to New Medical Products in…”
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Tasigna for Chronic and Accelerated Phase Philadelphia Chromosome–Positive Chronic Myelogenous Leukemia Resistant to or Intolerant of Imatinib by HAZARIKA, Maitreyee, XIAOPING JIANG, TIMMER, William, HARAPANHALLI, Ravi, DAGHER, Ramzi, JUSTICE, Robert, PAZDUR, Richard, QI LIU, LEE, Shwu-Luan, RAMCHANDANI, Roshni, GARNETT, Christine, ORR, Micheal S, SRIDHARA, Rajeshwari, BOOTH, Brian, LEIGHTON, John K

“…Purpose: This Food and Drug Administration (FDA) approval report describes the data and analyses leading to the approval by the FDA of nilotinib (Tasigna,…”
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Ixabepilone in Combination with Capecitabine and as Monotherapy for Treatment of Advanced Breast Cancer Refractory to Previous Chemotherapies by Lechleider, Robert J, Kaminskas, Edvardas, Jiang, Xiaoping, Aziz, Robeena, Bullock, Julie, Kasliwal, Ravindra, Harapanhalli, Ravi, Pope, Sarah, Sridhara, Rajeshwari, Leighton, John, Booth, Brian, Dagher, Ramzi, Justice, Robert, Pazdur, Richard

“…Purpose: To describe the considerations leading to marketing approval of ixabepilone in combination with capecitabine and as monotherapy for the treatment of…”
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Synthesis and Biologic Evaluation of a Radioiodinated Quinazolinone Derivative for Enzyme-Mediated Insolubilization Therapy by Ho, Nan-hui, Harapanhalli, Ravi S, Dahman, Bassam A, Chen, Kai, Wang, Ketai, Adelstein, S. James, Kassis, Amin I

“…We have developed a new strategy that aims to concentrate therapeutic radionuclides within solid tumors. This approach, which we have named EMIT…”
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[125I/127I]IodoHoechst 33342:  Synthesis, DNA Binding, and Biodistribution by Harapanhalli, Ravi S, McLaughlin, Larry W, Howell, Roger W, Rao, Dandamudi V, Adelstein, S. James, Kassis, Amin I

“…An iodinated analog of the DNA-minor-groove-binding agent Hoechst 33342 has been synthesized and evaluated for DNA binding and tumor targeting. The…”
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[125I/127I/131I]Iodorhodamine:  Synthesis, Cellular Localization, and Biodistribution in Athymic Mice Bearing Human Tumor Xenografts and Comparison with [99mTc]Hexakis(2-methoxyisobutylisonitrile) by Harapanhalli, Ravi S, Roy, Aloka M, Adelstein, S. James, Kassis, Amin I

“…The synthesis of halogenated rhodamine (Rh) derivatives was carried out by controlling the stoichiometry of the halogenating agents, bromine and iodine…”
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Comparison of Strand Breaks in Plasmid DNA after Positional Changes of Auger Electron-Emitting Iodine-125 by Kassis, Amin I., Harapanhalli, Ravi S., Adelstein, S. James

“…To elucidate the kinetics of the induction of DNA strand breaks by low-energy Auger electron emitters, we compared the yields of DNA breaks in supercoiled…”
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Strand Breaks in Plasmid DNA after Positional Changes of Auger Electron-Emitting Iodine-125: Direct Compared to Indirect Effects by Kassis, Amin I., Harapanhalli, Ravi S., Adelstein, S. James

“…To elucidate the nature and kinetics of DNA strand breaks caused by low-energy Auger electron emitters, we compared the yields of DNA breaks in supercoiled…”
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Regulatory Considerations in the Development of Low‐Dose Solid Oral Drug Products by Harapanhalli, Ravi S

“…This chapter contains sections titled: Introduction and Overview Three‐Pronged Approach to Low‐Dose Formulations Pharmaceutical Development Report Facility…”
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Radioprotection by DMSO against the biological effects of incorporated radionuclides in vivo--Comparison with other radioprotectors and evidence for indirect action of Auger electrons by Goddu, S M, Narra, V R, Harapanhalli, R S, Howell, R W, Rao, D V

“…Dimethyl sulfoxide (DMSO) was studied for its capacity to protect against the biological effects of chronic irradiation by incorporated radionuclides…”
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Lysine-Directed Conjugation of Ethidium Homodimer to B72.3 Antibody: Retention of Immunoreactivity but Altered Tumor Targeting by Harapanhalli, Ravi S, Matalka, Khalid Z, Jones, Peter L, Mahmood, Ashfaq, Adelstein, S.James, Kassis, Amin I

“…Ethidium homodimer (EHD) was conjugated to B72.3 monoclonal antibody using a method whereby 85–90% of the conjugated EHD remains available for DNA…”
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Assay of radiographic contrast agents in mice plasma and testes by high-performance liquid chromatography by Harapanhalli, Ravi S, Yaghmai, Vahid, Patel, Yashwant D, Baker, Stephen R, Rao, Dandamudi V

“…A new buffer system is reported for the analysis of radiographic contrast agents (RCAs) sodium meglumine diatrizoate, iohexol, and iopamidol in mice plasma and…”
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Vitamins as Radioprotectors In Vivo II. Protection by Vitamin A and Soybean Oil against Radiation Damage Caused by Internal Radionuclides by Harapanhalli, Ravi S., Narra, Venkat R., Yaghmai, Vahid, Azure, Michael T., Goddu, S. Murty, Howell, Roger W., Rao, Dandamudi V.

“…Tissue-incorporated radionuclides impart radiation energy over extended periods of time depending on their effective half-lives. The capacity of vitamin A…”
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Effects of diatrizoate and iopamidol on spermatogenesis by Yaghmai, V, Harapanhalli, R S, Patel, Y D, Baker, S R, Rao, D V

“…The biological effects of iodinated contrast media were examined by using spermatogenesis in mouse testis as the experimental model. Spermhead survival and…”
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Radiotoxicity of Some Iodine-123, Iodine-125 and Iodine-131-Labeled Compounds in Mouse Testes: Implications for Radiopharmaceutical Design by Narra, Venkat R, Howell, Roger W, Harapanhalli, Ravi S, Sastry, Kandula S. R, Rao, Dandamudi V

“…In this work, spermhead survival in mouse testis was used to investigate the radiotoxicity of several intratesticularly localized radioiodinated…”
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Antioxidant effects of vitamin C in mice following X-irradiation by Harapanhalli, R S, Yaghmai, V, Giuliani, D, Howell, R W, Rao, D V

“…The influence of supplemental vitamin C on the survival of nucleated bone marrow cells was examined in Swiss Webster mice following whole-body sublethal X…”
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Mural delivery of iloprost with use of hydrogel-coated balloon catheters suppresses local platelet aggregation by Kandarpa, K, Nakatsuka, S, Bravo, S M, Harapanhalli, R S, Barry, J J

“…To develop reproducible and quantifiable methods for mural delivery of iloprost, a potent agent against platelet aggregation, with use of hydrogel-coated…”
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Vitamins as Radioprotectors In Vivo. I. Protection by Vitamin C against Internal Radionuclides in Mouse Testes: Implications to the Mechanism of Damage Caused by the Auger Effect by Narra, Venkat R., Harapanhalli, Ravi S., Howell, Roger W., Kandula S. R. Sastry, Rao, Dandamudi V.

“…The potential of vitamin C, an antioxidant, to protect the radiosensitive spermatogonial cells in mouse testes against the effects of chronic irradiation by…”
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