Search Results - "Haramura, Masayuki"

Identification and purification of target protein using affinity resin bearing a photo-labile linker by Mabuchi, Miyuki, Shimizu, Tadashi, Haramura, Masayuki, Tanaka, Akito

“…[Display omitted] This Letter presents an effective method for the identification of target proteins of bioactive compounds such as drugs, natural products,…”
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Distinct cell surface proteome profiling by biotin labeling and glycoprotein capturing by Nagano, Kohji, Shinkawa, Takashi, Kato, Kuniyasu, Inomata, Noriyuki, Yabuki, Nami, Haramura, Masayuki

“…We performed here MS-based cell surface proteome profiling of HCT-116 cells by two distinct methods based on biotin labeling and glycoprotein capturing. In…”
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Reduction of nonspecific binding proteins to self-assembled monolayer on gold surface by Furuya, Minoru, Haramura, Masayuki, Tanaka, Akito

“…Application of 1 on gold surface enabled adequate estimation of K d value between FK506 and FKBP12 by SPR not only using purified FKBP12 but using Escherichia…”
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Application of chemical biology to proteomics in drug target discovery by Haramura, Masayuki

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Factor VIIa inhibitors: Target hopping in the serine protease family using X-ray structure determination by Shiraishi, Takuya, Kadono, Shojiro, Haramura, Masayuki, Kodama, Hirofumi, Ono, Yoshiyuki, Iikura, Hitoshi, Esaki, Tohru, Koga, Takaki, Hattori, Kunihiro, Watanabe, Yoshiaki, Sakamoto, Akihisa, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Esaki, Keiko, Ohta, Masateru, Sato, Haruhiko, Kozono, Toshiro

“…We succeeded in target hopping in the serine protease family using crystal structures of human FVIIa/TF in complex with peptide mimetic inhibitors. Selective…”
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Design and Synthesis of Peptidomimetic Factor VIIa Inhibitors by Shiraishi, Takuya, Kadono, Shojiro, Haramura, Masayuki, Kodama, Hirofumi, Ono, Yoshiyuki, Iikura, Hitoshi, Esaki, Tohru, Koga, Takaki, Hattori, Kunihiro, Watanabe, Yoshiaki, Sakamoto, Akihisa, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Esaki, Keiko, Ohta, Masateru, Sato, Haruhiko, Kozono, Toshiro

“…Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is regarded as a promising target for developing new anticoagulant drugs. In previous…”
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Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor by Kadono, Shojiro, Sakamoto, Akihisa, Kikuchi, Yasufumi, Oh-eda, Masayoshi, Yabuta, Naohiro, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Suzuki, Tsukasa, Koga, Takaki, Hattori, Kunihiro, Shiraishi, Takuya, Haramura, Masayuki, Kodama, Hirofumi, Ono, Yoshiyuki, Esaki, Toru, Sato, Haruhiko, Watanabe, Yoshiaki, Itoh, Susumu, Ohta, Masateru, Kozono, Toshiro

“…Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is seen as a promising target for developing new anticoagulant drugs. Structure-based designs…”
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Patient-reported burden of symptoms in neuromyelitis optica: A secondary analysis on pain and quality of life by Fujihara, Kazuo, Hattori, Satoshi, Kleiter, Ingo, Levy, Michael, Matsuda, Yuya, Mitsutake, Asako, Haramura, Masayuki, Palace, Jacqueline, Yamamura, Takashi

“…Relapses of neuromyelitis optica spectrum disorder (NMOSD) result in cumulative neurologic disabilities, are unpredictable, and are interspersed with…”
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Novel interactions of large P3 moiety and small P4 moiety in the binding of the peptide mimetic factor VIIa inhibitor by Kadono, Shojiro, Sakamoto, Akihisa, Kikuchi, Yasufumi, Oh-eda, Masayoshi, Yabuta, Naohiro, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Suzuki, Tsukasa, Koga, Takaki, Hattori, Kunihiro, Shiraishi, Takuya, Haramura, Masayuki, Kodama, Hirofumi, Ono, Yoshiyuki, Esaki, Toru, Sato, Haruhiko, Watanabe, Yoshiaki, Itoh, Susumu, Ohta, Masateru, Kozono, Toshiro

“…Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is seen as a promising target for developing new anticoagulant drugs. A novel peptide mimetic…”
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Structure of Gefitinib by TANAKA, Rumiko, HARAMURA, Masayuki, TANAKA, Akito, HIRAYAMA, Noriaki

“…The crystal of the title compound, C22H24ClFN4O3, belongs to space group P1 with cell dimensions of a = 8.928(1), b = 9.717(2), c = 12.604(2)Å, α = 93.31(1),…”
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Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery by Hatanaka, Takahiro, Haramura, Masayuki, Fei, You-Jun, Miyauchi, Seiji, Bridges, Christy C, Ganapathy, Preethi S, Smith, Sylvia B, Ganapathy, Vadivel, Ganapathy, Malliga E

“…We evaluated the potential of the Na(+)- and Cl(-)-coupled amino acid transporter ATB(0,+) as a delivery system for amino acid-based prodrugs…”
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Structure of Fipexide Hydrochloride Monohydrate by TANAKA, Rumiko, HARAMURA, Masayuki, TANAKA, Akito, HIRAYAMA, Noriaki

“…The crystal of the title compound, C20H21ClN2O4·HCl·H2O, belongs to space group Pccn with cell dimensions a = 30.76(1), b = 11.795(4), and c =11.524(4)Å. The…”
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Neuromyelitis optica spectrum disorder: Patient experience and quality of life by Beekman, Janine, Keisler, Aysha, Pedraza, Omar, Haramura, Masayuki, Gianella-Borradori, Athos, Katz, Eliezer, Ratchford, John N, Barron, Gerard, Cook, Lawrence J, Behne, Jacinta M, Blaschke, Terrence F, Smith, Terry J, Yeaman, Michael R

“…OBJECTIVETo gain insights into NMOSD disease impact, which may negatively affect QoL of patients, their families, and social network. METHODSThe current study…”
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Structure of Etophylline by TANAKA, Rumiko, HARAMURA, Masayuki, TANAKA, Akito, HIRAYAMA, Noriaki

“…The crystal of the title compound, C9H12N4O3, belongs to space group P21 with cell dimensions a = 4.522(1), b = 12.615(2), c = 9.093(2)Å, and β =…”
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Structure of Trimetazidine by TANAKA, Rumiko, HARAMURA, Masayuki, TANAKA, Akito, HIRAYAMA, Noriaki

“…The title compound is an antianginal agent. The crystal, C14H22N2O3·2HCl·1/2H2O, belongs to space group P21/a with cell dimensions of a = 13.139(6), b =…”
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Structure of Nadolol by TANAKA, Rumiko, HARAMURA, Masayuki, TANAKA, Akito, HIRAYAMA, Noriaki

“…The title compound, C17H27NO4, is an antihypertensive and antiangina agent. The crystal belongs to space group Cc with the cell dimensions a = 5.721(3), b =…”
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Design and Synthesis of N-terminal Cyclic Motilin Partial Peptides: A Novel Pure Motilin Antagonist by HARAMURA, Masayuki, OKAMACHI, Akira, TSUZUKI, Kouichi, YOGO, Kenji, IKUTA, Makoto, KOZONO, Toshiro, TAKANASHI, Hisanori, MURAYAMA, Eigoro

“…Motilin antagonist was designed and synthesized on the basis of the structure-activity relationship analysis of porcine motilin that we reported recently. The…”
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Structure of Guanethidine Monosulfate by TANAKA, Rumiko, HARAMURA, Masayuki, TANAKA, Akito, HIRAYAMA, Noriaki

“…The crystal of the title compound, C10H22N4·H2SO4, belongs to space group Pn with the cell dimensions a = 7.131(4), b = 12.969(6), c = 8.068(4)Å, and β =…”
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Structure of Flurandrenolide by TANAKA, Rumiko, HARAMURA, Masayuki, TANAKA, Akito, HIRAYAMA, Noriaki

“…The title compound, C24H33FO6, is a glucocorticoid. The crystal belongs to space group C2 with the cell dimensions a = 30.575(2), b = 9.3616(9), c = 17.012(5)Å…”
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Structure of Pimethixene Maleate by TANAKA, Rumiko, HARAMURA, Masayuki, TANAKA, Akito, HIRAYAMA, Noriaki

“…The crystal of the title compound, C19H19NS·C4H4O4, belongs to space group Pbca with cell dimensions of a = 17.0132(4), b = 9.3344(2), c = 26.1413(4)Å. The…”
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