Gastric autoimmunity in children and adolescents with type 1 diabetes: a prospective study

Type 1 diabetes (T1DM) is associated with gastric autoimmunity, which is characterized by the presence of parietal cell antibodies (APCA). We investigated gastric autoimmunity prevalence in T1DM children, its manifestations, determinants and association with thyroid gland (anti-Tg, anti-TPO) and pan...

Full description

Saved in:

Bibliographic Details
Published in:	Hormone research in paediatrics Vol. 77; no. 2; p. 121
Main Authors:	Kakleas, K, Kostaki, M, Critselis, E, Karayianni, C, Giannaki, M, Anyfantakis, K, Haramaras, I, Fotinou, A, Papathanasiou, A, Karavanaki, K
Format:	Journal Article
Language:	English
Published:	Switzerland 01-01-2012
Subjects:	Adolescent Autoantibodies - analysis Autoimmunity Child Cohort Studies Cross-Sectional Studies Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - immunology Female Follow-Up Studies Gastritis - complications Glutamate Decarboxylase - antagonists & inhibitors Greece Hospitals, University Humans Insulin-Secreting Cells - immunology Male Outpatient Clinics, Hospital Parietal Cells, Gastric - immunology Prospective Studies Thyroid Gland - immunology Greece
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Type 1 diabetes (T1DM) is associated with gastric autoimmunity, which is characterized by the presence of parietal cell antibodies (APCA). We investigated gastric autoimmunity prevalence in T1DM children, its manifestations, determinants and association with thyroid gland (anti-Tg, anti-TPO) and pancreatic β-cell autoimmunity (anti-GAD) at baseline and 4 years later. The initial cohort (D1) included 97 children with T1DM. At follow-up after 4 years (D2), 84.5% of participants were evaluated. We assessed APCA, anti-Tg, anti-TPO, and anti-GAD presence, as well as symptoms of gastritis. APCA-positive patients were evaluated with gastrin, B₁₂, ferritin levels and were submitted to gastroscopy. Thyroid antibody positivity was increased among the APCA-positive patients. Four years later, among initially APCA-positive patients, 2/6 became APCA negative, while 4/6 developed high titers of APCA. On gastroscopy, 2 patients had chronic hypertrophic gastritis and one Helicobacter pylori gastritis. Gastric autoimmunity was associated with thyroid autoimmunity and anti-GAD persistence. After 4 years, the majority of APCA-positive patients developed high titers of APCA and mild symptoms of gastritis. Thus, patients with T1DM, and in particular those with thyroid and/or pancreatic autoimmunity, should have periodic autoantibody screening for the early diagnosis and follow-up of gastric autoimmunity.
ISSN:	1663-2826
DOI:	10.1159/000336923