Nephrotic syndrome due to immunologically mediated hypocomplementic glomerulonephritis in a patient of Waldenström's macroglobulinemia

A 72-year-old man was diagnosed as having nephritic syndrome complicated by Waldenström's macroglobulinemia (WM). A monoclonal IgM lambda protein and decreased serum complements were observed. The renal biopsy disclosed the capillary occluded by thrombi which was stained with IgG, IgA, IgM, C4,...

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Bibliographic Details
Published in:	Nephron (2015) Vol. 92; no. 2; p. 452
Main Authors:	Haraguchi, Souichiro, Tomiyoshi, Yoshiyuki, Aoki, Shigehisa, Sakemi, Takanobu
Format:	Journal Article
Language:	English
Published:	Switzerland 01-10-2002
Subjects:	Aged Complement C4 - deficiency Complement System Proteins - deficiency Glomerulonephritis - complications Glomerulonephritis - immunology Glomerulonephritis - pathology Humans Immunoglobulin lambda-Chains - metabolism Immunoglobulin M - metabolism Male Microscopy, Electron Nephrotic Syndrome - etiology Nephrotic Syndrome - immunology Nephrotic Syndrome - pathology Waldenstrom Macroglobulinemia - complications Waldenstrom Macroglobulinemia - immunology Waldenstrom Macroglobulinemia - pathology
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Summary:	A 72-year-old man was diagnosed as having nephritic syndrome complicated by Waldenström's macroglobulinemia (WM). A monoclonal IgM lambda protein and decreased serum complements were observed. The renal biopsy disclosed the capillary occluded by thrombi which was stained with IgG, IgA, IgM, C4, lambda light chain and slight kappa light chain in a granular pattern. Electron dense deposits were noted in the subendothelial spaces. An unusual case of WM who developed nephrotic syndrome due to immunologically mediated hypocomplementic glomerulonephritis is described.
ISSN:	1660-8151
DOI:	10.1159/000063286