Search Results - "Haradahira, T"

Measurement of glycine binding site of N-methyl- d-aspartate (NMDA) receptors in living human brain using 4-Acetoxy derivative of l-703,717, 4-Acetoxy-7-chloro-3-[3-(4-[11C] methoxybenzyl) phenyl]-2(1 H)-quinolone (AcL703) with PET by Matsumoto, Ryohei, Haradahira, T., Ito, H., Fujimura, Y., Seki, C., Ikoma, Y., Maeda, J., Takano, A., Suzuki, K., Suhara, T.

“…[...]there are few suitable radioligands for imaging of the NMDA receptors in vivo at present. 7-Choloro-4-hydorxy-3-[3-(4-methoxybenzyl)…”
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A Prodrug of NMDA/Glycine Site Antagonist, L-703, 717, with Improved BBB Permeability: 4-Acetoxy Derivative and Its Positron-Emitter Labeled Analog by HARADAHIRA, Terushi, ZHANG, Ming-Rong, MAEDA, Jun, OKAUCHI, Takashi, KIDA, Takayo, KAWABE, Kouichi, SASAKI, Sigeki, SUHARA, Tetsuya, SUZUKI, Kazutoshi

“…4-Acetoxy derivative (1) of L-703, 717, a high-affinity (IC50=4.5 nM) antagonist for the glycine site of NMDA receptors, was synthesized and its brain uptake…”
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Automatic synthesis of l-[ β- 11C]amino acids using an immobilized enzyme column by Sasaki, M, Ikemoto, M, Mutoh, M, Haradahira, T, Tanaka, A, Watanabe, Y, Suzuki, K

“…We have developed a system for the automatic synthesis of l-[ β- 11C]amino acids for i.v. injection by means of enzyme-mediated reactions from 11CO 2 via 11CH…”
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Synthesis of L-[ β- 11C]amino acids using immobilized enzymes by Ikemoto, M., Sasaki, M., Haradahira, T., Yada, T., Omura, H., Furuya, Y., Watanabe, Y., Suzuki, K.

“…L-[ β- 11C]-3,4-dihydroxyphenylalanine(L-[ β- 11C]DOPA) and L-[ β- 11C]-5-hydroxytryptophan(L-[ β- 11C]-5-HTP) were synthesized in one step with immobilized…”
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A strategy for increasing the brain uptake of a radioligand in animals: use of a drug that inhibits plasma protein binding by Haradahira, Terushi, Zhang, Ming-Rong, Maeda, Jun, Okauchi, Takashi, Kawabe, Kouichi, Kida, Takayo, Suzuki, Kazutoshi, Suhara, Tetsuya

“…A positron-emitter labeled radioligand for the glycine-binding site of the N-methyl- d-aspartate (NMDA) receptor, [ 11C]L-703,717, was examined for its ability…”
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A new synthesis of [3- 11C]pyruvic acid using alanine racemase by Ikemoto, M., Sasaki, M., Haradahira, T., Okamoto, E., Omura, H., Furuya, Y., Watanabe, Y., Suzuki, K.

“…The synthesis of [3- 11C]pyruvic acid was attempted by two reaction systems (A: alanine racemase and d-amino acid oxidase, B: alanine racemase and l-alanine…”
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Potential tumor- or organ-imaging agents. 29. Radioiodinated esters and amides of 20-hydroxy- and 20-aminopregn-5-en-3 beta-ols by Haradahira, T, Schwendner, S W, Kojima, M, Counsell, R E

“…Radioiodinated benzoyl esters and amides of epimeric 20-hydroxy- and 20-aminopregn-5-en-3 beta-ols were synthesized in an effort to find an agent that would be…”
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Potential tumor- or organ-imaging agents. 29. Radioiodinated esters and amides of 20-hydroxy- and 20-aminopregn-5-en-3.beta.-ols by Haradahira, T, Schwendner, S. W, Kojima, M, Counsell, Raymond E

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Tumor Visualization with a Radioiodinated Phospholipid Ether by Counsell, Raymond E, Schwendner, Susan W, Meyer, Karen L, Haradahira, Terushi, Gross, Milton D

“…The known ability of phospholipid ethers to accumulate in certain tumors prompted the synthesis and evaluation of a radioiodinated phospholipid ether analog as…”
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N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[131I]iodo-5-methoxybenzyl)acetamide:  A Potent Iodinated Radioligand for the Peripheral-type Benzodiazepine Receptor in Brain by Zhang, Ming-Rong, Kumata, Katsushi, Maeda, Jun, Haradahira, Terushi, Noguchi, Junko, Suhara, Tetsuya, Halldin, Christer, Suzuki, Kazutoshi

“…To image the peripheral-type benzodiazepine receptor (PBR) in vivo, we previously developed two positron emission tomography (PET) ligands,…”
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N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[ super(131)I]iodo-5-methoxybenzyl) acetamide: A Potent Iodinated Radioligand for the Peripheral-type Benzodiazepine Receptor in Brain by Zhang, M-R, Kumata, K, Maeda, J, Haradahira, T, Noguchi, J, Suhara, T, Halldin, C, Suzuki, K

“…To image the peripheral-type benzodiazepine receptor (PBR) in vivo, we previously developed two positron emission tomography (PET) ligands, N-(2-[…”
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N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain by Zhang, Ming-Rong, Kumata, Katsushi, Maeda, Jun, Haradahira, Terushi, Noguchi, Junko, Suhara, Tetsuya, Halldin, Christer, Suzuki, Kazutoshi

“…To image the peripheral-type benzodiazepine receptor (PBR) in vivo, we previously developed two positron emission tomography (PET) ligands,…”
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Fluoro norcholesterol analogues. Synthesis of 6 beta-(2'-fluoro) ethyl-19-norcholest-5(10)-en-3 beta-ol by Kobayashi, T, Maeda, M, Haradahira, T, Kojima, M

“…A synthetic route for labelling 6 beta-(2'-fluoro)ethyl-19-norcholest-5(10)-en-3 beta-ol (VII) with fluorine-18 was developed to evaluate the potential utility…”
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Difference in brain distributions of carbon 11-labeled 4-hydroxy-2(1 H )-quinolones as PET radioligands for the glycine-binding site of the NMDA ion channel by Fuchigami, Takeshi, Haradahira, Terushi, Fujimoto, Noriko, Okauchi, Takashi, Maeda, Jun, Suzuki, Kazutoshi, Suhara, Tetsuya, Yamamoto, Fumihiko, Sasaki, Shigeki, Mukai, Takahiro, Yamaguchi, Hiroshi, Ogawa, Mikako, Magata, Yasuhiro, Maeda, Minoru

“…Abstract High-affinity iodine- and ethyl-C-5 substituted analogs of 4-hydroxy-3-(3-[11 C]methoxyphenyl)-2(1 H )-quinolone ([11 C]4HQ) were synthesized as new…”
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Synthesis and evaluation of 3-(4-chlorobenzyl)-8-[11C]methoxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one: a PET tracer for imaging sigma(1) receptors by Zhang, Ming-Rong, Haradahira, Terushi, Maeda, Jun, Okauchi, Takashi, Kawabe, Kouichi, Kida, Takayo, Obayashi, Shigeru, Suzuki, Kazutoshi, Suhara, Tetsuya

“…3-(4-Chlorobenzyl)-8-methoxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one (1), a putative dopamine D(4) receptor antagonist (k(i) = 8.7 nM), was labeled by…”
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Effects of endogenous agonists, glycine and D-serine, on in vivo specific binding of [11C]L-703,717, a PET radioligand for the glycine-binding site of NMDA receptors by Haradahira, Terushi, Okauchi, Takashi, Maeda, Jun, Zhang, Ming-Rong, Nishikawa, Toru, Konno, Ryouichi, Suzuki, Kazutoshi, Suhara, Tetsuya

“…A positron‐emitter (carbon‐11) labeled antagonist for the glycine‐binding site of NMDA receptors, [11C]L‐703,717, has a unique in vivo binding characteristic,…”
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Syntheses and pharmacological evaluation of two potent antagonists for dopamine D 4 receptors: [ 11 C]YM-50001 and N -[2-[4-(4-Chlorophenyl)-piperizin-1-yl]ethyl]-3-[ 11 C]methoxybenzamide by Zhang, Ming-Rong, Haradahira, Terushi, Maeda, Jun, Okauchi, Takashi, Kawabe, Kouichi, Noguchi, Junko, Kida, Takayo, Suzuki, Kazutoshi, Suhara, Tetsuya

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Synthesis and preliminary PET study of the 5-HT7 receptor antagonist [11C]DR4446 by Zhang, Ming-Rong, Haradahira, Terushi, Maeda, Jun, Okauchi, Takashi, Kida, Takayo, Obayashi, Shigeru, Suzuki, Kazutoshi, Suhara, Tetsuya

“…DR4446 (1‐methyl‐2a‐[4‐(4,5,6,7‐tetrahydrothieno[3,2‐c]pyridin‐5‐yl)butyl]‐2a,3,4,5‐tetrahydro‐1H‐benz[cd]indole‐2‐one) is a potent 5‐HT7 receptor antagonist…”
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Synthesis and preliminary evaluation of [ 18F]FEtP4A, a promising PET tracer for mapping acetylcholinesterase in vivo by Zhang, Ming-Rong, Tsuchiyama, Akio, Haradahira, Terushi, Furutsuka, Kenji, Yoshida, Yuichiro, Junko Noguchi, Takayo Kida, Irie, Toshiaki, Suzuki, Kazutoshi

“…N-[ 18F]Fluoroethyl-4-piperidyl acetate ([ 18F]FEtP4A), an analog of [ 11C]MP4A for mapping brain acetylcholineseterase (AchE) activity, was prepared by…”
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N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[ 131I]iodo-5methoxybenzyl) acetamide: A potent iodinated radioligand for peripheral benzodiazepine receptor in brain by Zhang, M, Maeda, J, Kumata, K, Noguchi, J, Haradahira, T, Suhara, T, Halldin, C, Suzuki, K

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