Search Results - "Harada, Yuka"

Myeloid neoplasms and clonal hematopoiesis from the RUNX1 perspective by Hayashi, Yoshihiro, Harada, Yuka, Harada, Hironori

“…RUNX1 is a critical transcription factor for the emergence of definitive hematopoiesis and the precise regulation of adult hematopoiesis. Dysregulation of its…”
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Recent advances in myelodysplastic syndromes: Molecular pathogenesis and its implications for targeted therapies by Harada, Hironori, Harada, Yuka

“…Myelodysplastic syndromes (MDS) are defined as stem cell disorders caused by various gene abnormalities. Recent analysis using next‐generation sequencing has…”
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A TLR–CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice by Zhang, Jing, Harada, Yuka, Hayashi, Yoshinori

“…Multiple sclerosis (MS) is a potentially disabling disease of the central nervous system. Approximately half of the patients with MS experience severe pain;…”
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Adult-onset hereditary myeloid malignancy and allogeneic stem cell transplantation by Toya, Takashi, Harada, Hironori, Harada, Yuka, Doki, Noriko

“…Hereditary myeloid malignancies, especially in adults or elderly persons, had been considered quite rare before the next-generation sequencing era; however,…”
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Impact of genetic alterations on central nervous system progression of primary vitreoretinal lymphoma by Yoshifuji, Kota, Sadato, Daichi, Toya, Takashi, Motomura, Yotaro, Hirama, Chizuko, Takase, Hiroshi, Yamamoto, Kouhei, Harada, Yuka, Mori, Takehiko, Nagao, Toshikage

“…Primary vitreoretinal lymphoma (PVRL) is a rare malignant lymphoma subtype with an unfavorable prognosis due to frequent central nervous system (CNS)…”
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IL36G-producing neutrophil-like monocytes promote cachexia in cancer by Hayashi, Yoshihiro, Kamimura-Aoyagi, Yasushige, Nishikawa, Sayuri, Noka, Rena, Iwata, Rika, Iwabuchi, Asami, Watanabe, Yushin, Matsunuma, Natsumi, Yuki, Kanako, Kobayashi, Hiroki, Harada, Yuka, Harada, Hironori

“…Most patients with advanced cancer develop cachexia, a multifactorial syndrome characterized by progressive skeletal muscle wasting. Despite its catastrophic…”
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Prognostic impact of TP53 mutation, monosomal karyotype, and prior myeloid disorder in nonremission acute myeloid leukemia at allo-HSCT by Najima, Yuho, Sadato, Daichi, Harada, Yuka, Oboki, Keisuke, Hirama, Chizuko, Toya, Takashi, Doki, Noriko, Haraguchi, Kyoko, Yoshifuji, Kota, Akiyama, Megumi, Inamoto, Kyoko, Igarashi, Aiko, Kobayashi, Takeshi, Kakihana, Kazuhiko, Okuyama, Yoshiki, Sakamaki, Hisashi, Harada, Hironori, Ohashi, Kazuteru

“…Outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in nonremission acute myeloid leukemia (AML) are dismal [2-year overall survival…”
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Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis by Harada, Yuka, Zhang, Jing, Imari, Kazuhisa, Yamasaki, Ryo, Ni, Junjun, Wu, Zhou, Yamamoto, Kenji, Kira, Jun-ichi, Nakanishi, Hiroshi, Hayashi, Yoshinori

“…Pain is a frequent and disabling symptom in patients with multiple sclerosis (MS); however, the underlying mechanisms of MS-related pain are not fully…”
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Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes by Aoyagi, Yasushige, Hayashi, Yoshihiro, Harada, Yuka, Choi, Kwangmin, Matsunuma, Natsumi, Sadato, Daichi, Maemoto, Yuki, Ito, Akihiro, Yanagi, Shigeru, Starczynowski, Daniel T, Harada, Hironori

“…Ineffective hematopoiesis is a fundamental process leading to the pathogenesis of myelodysplastic syndromes (MDS). However, the pathobiological mediators of…”
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Effect of IL-18 on the Expansion and Phenotype of Human Natural Killer Cells: Application to Cancer Immunotherapy by Senju, Hiroaki, Kumagai, Asuka, Nakamura, Yoichi, Yamaguchi, Hiroyuki, Nakatomi, Katsumi, Fukami, Shota, Shiraishi, Kengo, Harada, Yuka, Nakamura, Mitsuhiro, Okamura, Haruki, Tanaka, Yoshimasa, Mukae, Hiroshi

“…When pathogenic stresses are recognized by innate immune cells, inflammasomes are assembled and caspase-1 is activated, resulting in the conversion of…”
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KCNMB3 in spinal microglia contributes to the generation and maintenance of neuropathic pain in mice by Imari, Kazuhisa, Harada, Yuka, Zhang, Jing, Mori, Yoshihide, Hayashi, Yoshinori

“…Neuropathic pain is one of most intense types of chronic pain. Numerous studies investigating neuropathic pain have described the critical involvement of…”
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Gene rearrangements of MLL and RUNX1 sporadically occur in normal CD34+ cells under cytokine stimulation by Harada, Yuka, Shingai, Naoki, Ding, Ye, Sadato, Daichi, Hayashi, Yoshihiro, Yamaguchi, Masaki, Okuyama, Yoshiki, Shimoyama, Tatsu, Ohashi, Kazuteru, Harada, Hironori

“…Gene rearrangements of MLL/KMT2A or RUNX1 are the major cause of therapy‐related leukemia. Moreover, MLL rearrangements are the major cause of infant leukemia,…”
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Successful treatment of two cases with Philadelphia-chromosome positive acute lymphoblastic leukemia who relapsed after allogeneic stem cell transplantation and the treatments with novel immunotherapies and ponatinib by Tachibana, Takayoshi, Tanaka, Masatsugu, Noguchi, Yuma, Najima, Yuho, Sadato, Daichi, Harada, Yuka, Tamai, Yotaro, Doki, Noriko, Nakajima, Hideaki

“…The outcomes of relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) resistant to new drugs such as tyrosine kinase inhibitors,…”
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Archival bone marrow smears are useful in targeted next-generation sequencing for diagnosing myeloid neoplasms by Sadato, Daichi, Hirama, Chizuko, Kaiho-Soma, Ai, Yamaguchi, Ayaka, Kogure, Hiroko, Takakuwa, Sonomi, Ogawa, Mina, Doki, Noriko, Ohashi, Kazuteru, Harada, Hironori, Oboki, Keisuke, Harada, Yuka

“…Gene abnormalities, including mutations and fusions, are important determinants in the molecular diagnosis of myeloid neoplasms. The use of bone marrow (BM)…”
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Overexpression of RUNX3 represses RUNX1 to drive transformation of myelodysplastic syndrome by Yokomizo-Nakano, Takako, Kubota, Sho, Bai, Jie, Hamashima, Ai, Morii, Mariko, Sun, Yuqi, Katagiri, Seiichiro, Iimori, Mihoko, Kanai, Akinori, Tanaka, Daiki, Oshima, Motohiko, Harada, Yuka, Ohyashiki, Kazuma, Iwama, Atsushi, Harada, Hironori, Osato, Motomi, Sashida, Goro

“…RUNX3, a RUNX family transcription factor, regulates normal hematopoiesis and functions as a tumor suppressor in various tumors in humans and mice. However,…”
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The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis by Ikeda, Naoki, Kubota, Hiroaki, Suzuki, Risa, Morita, Mitsuki, Yoshimura, Ayana, Osada, Yuya, Kishida, Keigo, Kitamura, Daiki, Iwata, Ayaka, Yotsumoto, Satoshi, Kurotaki, Daisuke, Nishimura, Koutarou, Nishiyama, Akira, Tamura, Tomohiko, Kamatani, Takashi, Tsunoda, Tatsuhiko, Murakawa, Miyako, Asahina, Yasuhiro, Hayashi, Yoshihiro, Harada, Hironori, Harada, Yuka, Yokota, Asumi, Hirai, Hideyo, Seki, Takao, Kuwahara, Makoto, Yamashita, Masakatsu, Shichino, Shigeyuki, Tanaka, Masato, Asano, Kenichi

“…Inflammatory stimuli cause a state of emergency myelopoiesis leading to neutrophil-like monocyte expansion. However, their function, the committed precursors,…”
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Attenuated humoral response against SARS‐CoV‐2 mRNA vaccination in allogeneic stem cell transplantation recipients by Toya, Takashi, Atsuta, Yuya, Sanada, Takahiro, Honda, Tomoko, Sadato, Daichi, Sekiya, Noritaka, Kogure, Hiroko, Takakuwa, Sonomi, Onai, Daishi, Shingai, Naoki, Shimizu, Hiroaki, Najima, Yuho, Kobayashi, Takeshi, Ohashi, Kazuteru, Harada, Yuka, Kohara, Michinori, Doki, Noriko

“…Antibody persistence several months after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) mRNA vaccination in allogeneic stem cell transplantation…”
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Impact of gene alterations on clinical outcome in young adults with myelodysplastic syndromes by Konishi, Tatsuya, Sadato, Daichi, Toya, Takashi, Hirama, Chizuko, Kishida, Yuya, Nagata, Akihito, Yamada, Yuta, Shingai, Naoki, Shimizu, Hiroaki, Najima, Yuho, Kobayashi, Takeshi, Haraguchi, Kyoko, Okuyama, Yoshiki, Harada, Hironori, Ohashi, Kazuteru, Harada, Yuka, Doki, Noriko

“…Young adults with myelodysplastic syndrome (MDS) are rare, and the clinical significance of driver mutations has not yet been analysed. We analysed the gene…”
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AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms by Ding, Ye, Harada, Yuka, Imagawa, Jun, Kimura, Akiro, Harada, Hironori

“…Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by proliferation of one or more myeloid cell lineages. Some…”
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Myeloid neoplasms and clonal hematopoiesis from the RUNX1 perspective by Hayashi, Yoshihiro, Harada, Yuka, Harada, Hironori

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