Search Results - "Harada, Yui"

Phospholipase C-related, but catalytically inactive protein (PRIP) up-regulates osteoclast differentiation via calcium-calcineurin-NFATc1 signaling by Murakami, Ayako, Matsuda, Miho, Harada, Yui, Hirata, Masato

“…Phospholipase C-related, but catalytically inactive protein (PRIP) was previously identified as a novel inositol 1,4,5-trisphosphate-binding protein with a…”
Get full text

Increased Rac1 Activation in the Enhanced Carbachol-Induced Bronchial Smooth Muscle Contraction of Repeatedly Antigen-Challenged Mice by Kai, Yuki, Motegi, Momoko, Suzuki, Yuta, Harada, Yui, Takeuchi, Hiroto, Kon, Risako, Ikarashi, Nobutomo, Chiba, Yoshihiko, Kamei, Junzo, Sakai, Hiroyasu

“…Recently, we demonstrated that Rac1 upregulation is involved in augmented bronchial smooth muscle (BSM) contractions of antigen-challenged mice. However,…”
Get full text

Fc‐Binding Antibody‐Recruiting Molecules Targeting Prostate‐Specific Membrane Antigen: Defucosylation of Antibody for Efficacy Improvement by Sasaki, Koichi, Harada, Minori, Yoshikawa, Takuma, Tagawa, Hiroshi, Harada, Yui, Yonemitsu, Yoshikazu, Ryujin, Takaaki, Kishimura, Akihiro, Mori, Takeshi, Katayama, Yoshiki

“…Synthetic small molecules that redirect endogenous antibodies to target cells are promising drug candidates because they overcome the potential shortcomings of…”
Get full text

Up‐regulation of Rac1 in the bronchial smooth muscle of murine experimental asthma by Kai, Yuki, Motegi, Momoko, Suzuki, Yuta, Takeuchi, Hiroto, Harada, Yui, Sato, Fumiaki, Chiba, Yoshihiko, Kamei, Junzo, Sakai, Hiroyasu

“…There has been considerable research on the involvement of RhoA/Rho kinase signalling in smooth muscle contractions. However, only a few reports have addressed…”
Get full text

Bif‐1/Endophilin B1/SH3GLB1 regulates bone homeostasis by Touyama, Kenya, Khan, Masud, Aoki, Kazuhiro, Matsuda, Miho, Hiura, Fumitaka, Takakura, Nana, Matsubara, Takuma, Harada, Yui, Hirohashi, Yuna, Tamura, Yukihiko, Gao, Jing, Mori, Kayo, Kokabu, Shoichiro, Yasuda, Hisataka, Fujita, Yuko, Watanabe, Koji, Takahashi, Yoshinori, Maki, Kenshi, Jimi, Eijiro

“…Skeletal tissue homeostasis is maintained via the balance of osteoclastic bone resorption and osteoblastic bone formation. Autophagy and apoptosis are…”
Get full text

Dramatic improvement of DC-based immunotherapy against various malignancies by Harada, Yui, Yonemitsu, Yoshikazu

“…Dendritic cells (DCs) play a crucial role in maintaining the immune system. Though DC-based cancer immunotherapy has been suggested as a potential treatment…”
Get full text

782-F Pseudoprogression and subsequent shrinkage of refractory/relapsed pediatric solid tumors induced by GAIA-102: an interim report of the single-agent cohort in Phase I clinical trial by Kawakubo, Naonori, Harada, Yui, Tamaki, Akihiko, Maniwa, Junnosuke, Morodomi, Yosuke, Yonemitsu, Yoshikazu, Tajiri, Tatsuro

“…BackgroundPseudoprogression and subsequent shrinkage of solid tumor foci are typical clinical processes and are seen in approximately 2–8% of cases during…”
Get full text

Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix-Directed Spheroid Formation by Kasagi, Yuta, Harada, Yui, Morodomi, Yosuke, Iwai, Toshiki, Saito, Satoru, Yoshida, Kumi, Oki, Eiji, Saeki, Hiroshi, Ohgaki, Kippei, Sugiyama, Masahiko, Onimaru, Mitsuho, Maehara, Yoshihiko, Yonemitsu, Yoshikazu

“…Peritonitis carcinomatosa is an advanced and intractable state of gastrointestinal and ovarian cancer, where mechanistic elucidation might enable the…”
Get full text

Capecitabine reverses tumor escape from anti-VEGF through the eliminating CD11bhigh/Gr1high myeloid cells by Iwai, Toshiki, Harada, Yui, Saeki, Hiroshi, Oki, Eiji, Maehara, Yoshihiko, Yonemitsu, Yoshikazu

“…The anti-VEGF humanized antibody bevacizumab suppresses various malignancies, but tumors can acquire drug resistance. Preclinical studies suggest…”
Get full text

Carbon‐ion beam treatment induces systemic antitumor immunity against murine squamous cell carcinoma by Matsunaga, Akinao, Ueda, Yasuji, Yamada, Shigeru, Harada, Yui, Shimada, Hideaki, Hasegawa, Mamoru, Tsujii, Hirohiko, Ochiai, Takenori, Yonemitsu, Yoshikazu

“…BACKGROUND: Carbon‐ion beam (CIB) treatment is a powerful tool for controlling primary tumors in the clinical setting. However, to date, few clinical or…”
Get full text

BubR1 Insufficiency Inhibits Neointimal Hyperplasia Through Impaired Vascular Smooth Muscle Cell Proliferation in Mice by Kyuragi, Ryoichi, Matsumoto, Takuya, Harada, Yui, Saito, Satoru, Onimaru, Mitsuho, Nakatsu, Yoshimichi, Tsuzuki, Teruhisa, Nomura, Masatoshi, Yonemitsu, Yoshikazu, Maehara, Yoshihiko

“…OBJECTIVE—BubR1, a cell cycle–related protein, is an essential component of the spindle checkpoint that regulates cell division. Mice with BubR1 expression…”
Get full text

BubR1 Insufficiency Results in Decreased Macrophage Proliferation and Attenuated Atherogenesis in Apolipoprotein E‐Deficient Mice by Tanaka, Shinichi, Matsumoto, Takuya, Matsubara, Yutaka, Harada, Yui, Kyuragi, Ryoichi, Koga, Jun‐ichiro, Egashira, Kensuke, Nakashima, Yutaka, Yonemitsu, Yoshikazu, Maehara, Yoshihiko

“…Background Budding uninhibited by benzimidazole‐related 1 (BubR1), a cell cycle–related protein, is an essential component of the spindle checkpoint that…”
Get full text

Cytokine-based high log-scale expansion of functional human dendritic cells from cord-blood CD34-positive cells by Harada, Yui, Okada-Nakanishi, Yae, Ueda, Yasuji, Tsujitani, Shunichi, Saito, Satoru, Fuji-Ogawa, Terumi, Iida, Akihiro, Hasegawa, Mamoru, Ichikawa, Tomohiko, Yonemitsu, Yoshikazu

“…Dendritic cells (DCs) play a crucial role in maintaining the immune system. Though DC-based cancer immunotherapy has been suggested as a potential treatment…”
Get full text

RIG-I Helicase-Independent Pathway in Sendai Virus-Activated Dendritic Cells Is Critical for Preventing Lung Metastasis of AT6.3 Prostate Cancer by Kato, Tomonori, Ueda, Yasuji, Kinoh, Hiroaki, Yoneyama, Yasuo, Matsunaga, Akinao, Komaru, Atsushi, Harada, Yui, Suzuki, Hiroyoshi, Komiya, Akira, Shibata, Satoko, Hasegawa, Mamoru, Hayashi, Hideki, Ichikawa, Tomohiko, Yonemitsu, Yoshikazu

“…We recently demonstrated highly efficient antitumor immunity against dermal tumors of B16F10 murine melanoma with the use of dendritic cells (DCs) activated by…”
Get full text

Antagonism of VEGF by genetically engineered dendritic cells is essential to induce antitumor immunity against malignant ascites by Sugiyama, Masahiko, Kakeji, Yoshihiro, Tsujitani, Shunichi, Harada, Yui, Onimaru, Mitsuho, Yoshida, Kumi, Tanaka, Sakura, Emi, Yasunori, Morita, Masaru, Morodomi, Yosuke, Hasegawa, Mamoru, Maehara, Yoshihiko, Yonemitsu, Yoshikazu

“…Malignant ascitis (MA) is a highly intractable and immunotherapy-resistant state of advanced gastrointestinal and ovarian cancers. Using a murine model of MA…”
Get full text

Ex vivo generation of highly purified and activated natural killer cells from human peripheral blood by Saito, Satoru, Harada, Yui, Morodomi, Yosuke, Onimaru, Mitsuho, Yoshida, Kumi, Kyuragi, Ryoichi, Matsubara, Hisahiro, Yonemitsu, Yoshikazu

“…Adoptive immunotherapy using natural killer (NK) cells has been a promising treatment for intractable malignancies; however, there remain a number of…”
Get more information

Cytokine-based log-scale expansion of functional murine dendritic cells by Harada, Yui, Ueda, Yasuji, Kinoh, Hiroaki, Komaru, Atsushi, Fuji-Ogawa, Terumi, Furuya, Aki, Iida, Akihiro, Hasegawa, Mamoru, Ichikawa, Tomohiko, Yonemitsu, Yoshikazu

“…Limitations of the clinical efficacy of dendritic cell (DC)-based immunotherapy, as well as difficulties in their industrial production, are largely related to…”
Get full text

GAIA-102 cells, an off-the-shelf and highly activated NK-like cell product, elicit endogenous immune cell responses in solid tumor model by Zheng, Situo, Harada, Yui, Morodomi, Yosuke, Yonemitsu, Yoshikazu

“…Abstract [Background] We have developed a novel method for generating highly activated NK-like cells (GAIA-102) from mixed peripheral blood mononuclear cells…”
Get full text

Impact of monocytes on the proliferation of highly activated NK-like cells (GAIA-102) by Yuan, Shuyue, Harada, Yui, Morodomi, Yosuke, Nagata, Hiroko, Yonemitsu, Yoshikazu

“…Abstract [Background] There has been a growing clinical application of therapies using autologous and allogeneic natural killer (NK) cells. Researchers across…”
Get full text

150 GAIA-102: a new class off-the-shelf allogeneic NK-like cells that can eliminate solid tumors by Harada, Yui, Yonemitsu, Yoshikazu

“…BackgroundCancer immunotherapy has been established as a new therapeutic category since the recent success of immune checkpoint inhibitors and a type of…”
Get full text