Search Results - "Harada, Mitsunori"

Improved anti‐tumor activity of stabilized anthracycline polymeric micelle formulation, NC‐6300 by Harada, Mitsunori, Bobe, Iulian, Saito, Hiroyuki, Shibata, Naoya, Tanaka, Ryosuke, Hayashi, Tatsuyuki, Kato, Yasuki

“…Anthracyclines have long been considered to be among the most active agents clinically available for the treatment of breast cancer despite their toxicity. To…”
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NC‐6300, an epirubicin‐incorporating micelle, extends the antitumor effect and reduces the cardiotoxicity of epirubicin by Takahashi, Amane, Yamamoto, Yoshiyuki, Yasunaga, Masahiro, Koga, Yoshikatsu, Kuroda, Jun‐ichiro, Takigahira, Misato, Harada, Mitsunori, Saito, Hiroyuki, Hayashi, Tatsuyuki, Kato, Yasuki, Kinoshita, Taira, Ohkohchi, Nobuhiro, Hyodo, Ichinosuke, Matsumura, Yasuhiro

“…Epirubicin is widely used to treat various human tumors. However, it is difficult to achieve a sufficient antitumor effect because of dosage limitation to…”
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Reinforcement of antitumor effect of micelles containing anticancer drugs by binding of an anti-tissue factor antibody without direct cytocidal effects by Takashima, Hiroki, Koga, Yoshikatsu, Tsumura, Ryo, Yasunaga, Masahiro, Tsuchiya, Masami, Inoue, Tadashi, Negishi, Eriko, Harada, Mitsunori, Yoshida, Sei, Matsumura, Yasuhiro

“…It has been preclinically and clinically proven that anticancer agent–incorporating (ACA–incorporating) polymeric micelles selectively accumulate in tumor via…”
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Enhanced antitumor effect of anti‐tissue factor antibody‐conjugated epirubicin‐incorporating micelles in xenograft models by Yamamoto, Yoshiyuki, Hyodo, Ichinosuke, Koga, Yoshikatsu, Tsumura, Ryo, Sato, Ryuta, Obonai, Toshihumi, Fuchigami, Hirobumi, Furuya, Fumiaki, Yasunaga, Masahiro, Harada, Mitsunori, Kato, Yasuki, Ohtsu, Atsushi, Matsumura, Yasuhiro

“…For the creation of a successful antibody–drug conjugate (ADC), both scientific and clinical evidence has indicated that highly toxic anticancer agents (ACA)…”
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Prolonged circulation and in vivo efficacy of recombinant human granulocyte colony-stimulating factor encapsulated in polymeric micelles by Harada, Mitsunori, Ohuchi, Miho, Hayashi, Tatsuyuki, Kato, Yasuki

“…To improve the pharmacokinetics of granulocyte colony-stimulating factor (G-CSF) and decrease dosing frequency, polyethylene glycol polyglutamate block…”
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Fentanyl compared to buprenorphine for atrial fibrillation ablation analgesia and sedation: a retrospective cross-sectional study by Kinoshita, Teruhisa, Harada, Mitsunori, Takimoto, Norio, Shibata, Daichi, Sakakibara, Takashi, Adachi, Mamoru

“…The effects of general anesthesia with deep sedation and conscious sedation have been compared for sedation management in the perioperative period for…”
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Utility of epirubicin‐incorporating micelles tagged with anti‐tissue factor antibody clone with no anticoagulant effect by Sugaya, Akinori, Hyodo, Ichinosuke, Koga, Yoshikatsu, Yamamoto, Yoshiyuki, Takashima, Hiroki, Sato, Ryuta, Tsumura, Ryo, Furuya, Fumiaki, Yasunaga, Masahiro, Harada, Mitsunori, Tanaka, Ryosuke, Matsumura, Yasuhiro

“…Tissue factor (TF), an initiator of the extrinsic blood coagulation cascade, is overexpressed in different types of cancer. Tissue factor overexpression is…”
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Abstract 5525: Antibody/drug-conjugated micelle as a versatile platform technology for targeted tumor delivery by Harada, Mitsunori

“…Background: Antibody-drug conjugates (ADCs) have been recognized as a promising anticancer agent, despite their stringent requirements of antibody affinity,…”
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Prostacyclin Synthase Gene Transfer Accelerates Reendothelialization and Inhibits Neointimal Formation in Rat Carotid Arteries After Balloon Injury by Numaguchi, Yasushi, Naruse, Keiji, Harada, Mitsunori, Osanai, Hiroyuki, Mokuno, Shinji, Murase, Kichiro, Matsui, Hideo, Toki, Yukio, Ito, Takayuki, Okumura, Kenji, Hayakawa, Tetsuo

“…Prostacyclin (PGI2), a metabolite of arachidonic acid, has the vasoprotective effects of vasodilation, anti-platelet aggregation, and inhibition of smooth…”
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The Upgrade Strategy for a Patient with Implantable Cardioverter Defibrillator Complicated with the Total Occlusion of Left Subclavian Vein—The Usefulness of Subclavian Venoplasty by Asano, Yoshizumi, Harada, Mitsunori, Miyoshi, Aya, Kamiya, Shinji, Kajiguchi, Masahiro, Saito, Takayuki, Yamanaka, Yuji, Mokuno, Shinji

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Prostacyclin Synthase Gene Transfer Modulates Cyclooxygenase-2–Derived Prostanoid Synthesis and Inhibits Neointimal Formation in Rat Balloon-Injured Arteries by Yamada, Michiharu, Numaguchi, Yasushi, Okumura, Kenji, Harada, Mitsunori, Naruse, Keiji, Matsui, Hideo, Ito, Takayuki, Hayakawa, Tetsuo

“…Previous studies have shown that prostacyclin (PGI2) synthase (PCS) gene transfer inhibits neointimal formation in balloon-injured arteries. However, the role…”
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Effect of combined treatment with the epirubicin‐incorporating micelles (NC‐6300) and 1,2‐diaminocyclohexane platinum (II)‐incorporating micelles (NC‐4016) on a human gastric cancer model by Yamamoto, Yoshiyuki, Hyodo, Ichinosuke, Takigahira, Misato, Koga, Yoshikatsu, Yasunaga, Masahiro, Harada, Mitsunori, Hayashi, Tatsuyuki, Kato, Yasuki, Matsumura, Yasuhiro

“…Anticancer agent‐incorporating polymeric micelles accumulate effectively in tumors via the enhanced permeability and retention effect to exert potent antitumor…”
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NC-6004 Phase I study in combination with gemcitabine for advanced solid tumors and population PK/PD analysis by Doi, Toshihiko, Hamaguchi, Tetsuya, Shitara, Kohei, Iwasa, Satoru, Shimada, Yasuhiro, Harada, Mitsunori, Naito, Kenichiro, Hayashi, Naoto, Masada, Atsuhiro, Ohtsu, Atsushi

“…Objectives This study was an open-label phase I study to confirm the safety and tolerability of NC-6004 in combination with gemcitabine in Japanese patients…”
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OVA-bound nanoparticles induce OVA-specific IgG1, IgG2a, and IgG2b responses with low IgE synthesis by Yanase, Noriko, Toyota, Hiroko, Hata, Kikumi, Yagyu, Seina, Seki, Takahiro, Harada, Mitsunori, Kato, Yasuki, Mizuguchi, Junichiro

“…Abstract There is an urgent requirement for a novel vaccine that can stimulate immune responses without unwanted toxicity, including IgE elevation. We examined…”
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Magainin 1-induced leakage of entrapped calcein out of negatively-charged lipid vesicles by Matsuzaki, K, Harada, M, Handa, T, Funakoshi, S, Fujii, N, Yajima, H, Miyajima, K

“…Effects of magainin 1, a novel antimicrobial peptide, on the permeability of lipid vesicles were investigated by using calcein as a trapped fluorescent marker…”
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Combination therapy with dendritic cell vaccine and IL-2 encapsulating polymeric micelles enhances intra-tumoral accumulation of antigen-specific CTLs by Miki, Kenji, Nagaoka, Koji, Harada, Mitsunori, Hayashi, Tatsuyuki, Jinguji, Hidemasa, Kato, Yasuki, Maekawa, Ryuji

“…Dendritic cell (DC) vaccine is a promising immunotherapy for cancer due to its ability to induce antigen-specific CTLs efficiently. However, a number of…”
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Abstract 1368: Preclinical evaluation of NC-6201, an antibodydrug-conjugated micelle incorporating novel hemiasterlin analogue E7974 by Harada, Mitsunori, Tsuchiya, Masami, Miyazaki, Ryusuke, Inoue, Tadashi, Tanaka, Ryosuke, Yanagisawa, Yuuki, Ito, Masayoshi, Ito, Yu, Naito, Kenichiro

“…Background:…”
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Abstract 1368: Preclinical evaluation of NC-6201, an antibody/drug-conjugated micelle incorporating novel hemiasterlin analogue E7974 by Harada, Mitsunori, Tsuchiya, Masami, Miyazaki, Ryusuke, Inoue, Tadashi, Tanaka, Ryosuke, Yanagisawa, Yuuki, Ito, Masayoshi, Ito, Yu, Naito, Kenichiro

“…Background: Antibody-drug conjugates (ADCs) have been recognized as a promising anticancer agent. There have been a lot of registered clinical trials for ADCs…”
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Vaccination with OVA-bound nanoparticles encapsulating IL-7 inhibits the growth of OVA-expressing E.G7 tumor cells in vivo by TOYOTA, HIROKO, YANASE, NORIKO, YOSHIMOTO, TAKAYUKI, HARADA, MITSUNORI, KATO, YASUKI, MIZUGUCHI, JUNICHIRO

“…Immunotherapy has gained special attention due to its specific effects on tumor cells and systemic action to block metastasis. We recently demonstrated that…”
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The impact of the capability of circulating progenitor cell to differentiate on myocardial salvage in patients with primary acute myocardial infarction by NUMAGUCHI, Yasushi, SONE, Takahito, KONDO, Takahisa, MUROHARA, Toyoaki, OKUMURA, Kenji, ISHII, Masakazu, MORITA, Yasuhiro, KUBOTA, Ryuji, YOKOUCHI, Kazuhiko, IMAI, Hajime, HARADA, Mitsunori, OSANAI, Hiroyuki

“…Circulating endothelial progenitor cells (EPCs) are known to be involved in vasculogenesis and mobilized after acute myocardial infarction (AMI). To test the…”
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