Search Results - "Harada, Hiroshi"

Hypoxia-inducible factor 1–mediated characteristic features of cancer cells for tumor radioresistance by Harada, Hiroshi

“…Tumor hypoxia has been attracting increasing attention in the fields of radiation biology and oncology since Thomlinson and Gray detected hypoxic cells in…”
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How Can We Overcome Tumor Hypoxia in Radiation Therapy? by Harada, Hiroshi

“…Local recurrence and distant metastasis frequently occur after radiation therapy for cancer and can be fatal. Evidence obtained from radiochemical and…”
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Tumor microenvironment and radioresistance by Suwa, Tatsuya, Kobayashi, Minoru, Nam, Jin-Min, Harada, Hiroshi

“…Metastasis is not the result of a random event, as cancer cells can sustain and proliferate actively only in a suitable tissue microenvironment and then form…”
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Effects of Liquid Fraction on Reaction Rate of Molten Steel Desulfurization Using Solid-liquid Coexisting Slag by Matsuzawa, Akihiro, Harada, Hiroshi

“…In the high purification refining processes, a CaO-containing flux or slag is used commonly for the desulfurization of molten steel. Because the slag generated…”
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Regulatory mechanisms of hypoxia‐inducible factor 1 activity: Two decades of knowledge by Koyasu, Sho, Kobayashi, Minoru, Goto, Yoko, Hiraoka, Masahiro, Harada, Hiroshi

“…Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator of various genes related to cellular adaptive responses to hypoxia. Dysfunctions in the…”
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Space Radiation Biology for “Living in Space” by Furukawa, Satoshi, Nagamatsu, Aiko, Nenoi, Mitsuru, Fujimori, Akira, Kakinuma, Shizuko, Katsube, Takanori, Wang, Bing, Tsuruoka, Chizuru, Shirai, Toshiyuki, Nakamura, Asako J., Sakaue-Sawano, Asako, Miyawaki, Atsushi, Harada, Hiroshi, Kobayashi, Minoru, Kobayashi, Junya, Kunieda, Takekazu, Funayama, Tomoo, Suzuki, Michiyo, Miyamoto, Tatsuo, Hidema, Jun, Yoshida, Yukari, Takahashi, Akihisa

“…Space travel has advanced significantly over the last six decades with astronauts spending up to 6 months at the International Space Station. Nonetheless, the…”
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Successful Treatment of an Aggressive Adult T-cell Leukemia/Lymphoma with Strong CD30 Expression Using Brentuximab Vedotin as Combination and Maintenance Therapy by Baba, Yuta, Sakai, Hirotaka, Kabasawa, Nobuyuki, Harada, Hiroshi

“…Adult T-cell leukemia/lymphoma (ATL) is a highly aggressive malignant tumor associated with a poor prognosis. We herein report a 63-year-old man who was newly…”
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CAMTA1 is a useful immunohistochemical marker for diagnosing epithelioid haemangioendothelioma by Shibuya, Ryo, Matsuyama, Atsuji, Shiba, Eisuke, Harada, Hiroshi, Yabuki, Kei, Hisaoka, Masanori

“…Aims The diagnosis of epithelioid haemangioendothelioma (EHE) is usually straightforward, based on characteristic histological features. However, it is…”
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Successful Treatment of Immune Thrombocytopenic Purpura with Intracranial Hemorrhaging and Duodenal Bleeding Following SARS-CoV-2 Vaccination by Baba, Yuta, Sakai, Hirotaka, Kabasawa, Nobuyuki, Harada, Hiroshi

“…Several vaccines have been developed for coronavirus disease 2019 - caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - in record…”
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Development of a New ICT-Based Multisensor Blood Pressure Monitoring System for Use in Hemodynamic Biomarker-Initiated Anticipation Medicine for Cardiovascular Disease: The National IMPACT Program Project by Kario, Kazuomi, Tomitani, Naoko, Kanegae, Hiroshi, Yasui, Nobuhiko, Nishizawa, Masafumi, Fujiwara, Takeshi, Shigezumi, Takeya, Nagai, Ryozo, Harada, Hiroshi

“…We have developed a multisensor home and ambulatory blood pressure (BP) monitoring system for monitoring 24-h central and brachial BP variability concurrent…”
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Microenvironment and Radiation Therapy by Hiraoka, Masahiro, Harada, Hiroshi, Itasaka, Satoshi, Yoshimura, Michio

“…Dependency on tumor oxygenation is one of the major features of radiation therapy and this has led many radiation biologists and oncologists to focus on tumor…”
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Ubiquitin carboxyl‐terminal hydrolase L1 promotes hypoxia‐inducible factor 1‐dependent tumor cell malignancy in spheroid models by Li, Xuebing, Hattori, Akira, Takahashi, Senye, Goto, Yoko, Harada, Hiroshi, Kakeya, Hideaki

“…Hypoxia‐inducible factor 1 (HIF‐1) is a critical heterodimeric transcription factor for tumor malignancy. Recently, ubiquitin carboxyl‐terminal hydrolase L1…”
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HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death by Okamoto, Akihisa, Sumi, Chisato, Tanaka, Hiromasa, Kusunoki, Munenori, Iwai, Teppei, Nishi, Kenichiro, Matsuo, Yoshiyuki, Harada, Hiroshi, Takenaga, Keizo, Bono, Hidemasa, Hirota, Kiichi

“…The local anesthetic lidocaine induces cell death by altering reactive oxygen species (ROS) generation and mitochondrial electron transport chain function…”
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Ultrasonic Reflection Characteristics of Defects in Sheet Metal Forming —Effects of Wrinkles and Contaminant by Segawa, Yuji, Kuriyama, Takuya, Takeda, Keisuke, Harada, Hiroshi, Marumo, Yasuo, Imamura, Yasuhiro, Nonaka, Tomohiro, Sakata, Yutaka

“…Ultrasonic waves are effective in examining the contact state between the die and the material during sheet metal forming. In this study, ultrasonic…”
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Effect of Wettability on Penetration and Flotation Behavior of a Particle in Refining Process by Matsuzawa, Akihiro, Sasai, Katsuhiro, Harada, Hiroshi, Numata, Mitsuhiro

“…Powder blasting is often performed in refining processes for improving their reaction efficiency. Herein, the effect of wettability on penetration and…”
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Optimization for Centralized and Decentralized Cognitive Radio Networks by Hasegawa, Mikio, Hirai, Hiroshi, Nagano, Kiyohito, Harada, Hiroshi, Aihara, Kazuyuki

“…Cognitive radio technology improves radio resource usage by reconfiguring the wireless connection settings according to the optimum decisions, which are made…”
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Quantitative analysis of sulfur segregation at the oxide/substrate interface in Ni-base single crystal superalloy by Tabata, Chihiro, Kawagishi, Kyoko, Uzuhashi, Jun, Ohkubo, Tadakatsu, Hono, Kazuhiro, Yokokawa, Tadaharu, Harada, Hiroshi, Suzuki, Shinsuke

“…•Cyclic oxidation resistance of Ni-base superalloy, TMS-238, melt in Al2O3 crucible and CaO crucible were compared.•Comparison of sulfur segregation at…”
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CALPHAD approach for prediction of local phase transformation at superlattice stacking fault in gamma prime precipitates in superalloys with multi-component system by Saito, Takuma, Harada, Hiroshi, Abe, Taichi, Murakami, Hideyuki

“…This manuscript investigated the possibility of CALPHAD (calculation of phase diagram) approach to predict the local phase transformation (LPT) accompanied by…”
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Synthesis and biological evaluation of indolyl chalcones as antitumor agents by Kumar, Dalip, Kumar, N. Maruthi, Akamatsu, Kanako, Kusaka, Eriko, Harada, Hiroshi, Ito, Takeo

“…A series of indolyl chalcones were synthesized and evaluated for their in vitro anti-proliferative activities against various cancer cell lines. A series of…”
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HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs by Zhao, Tao, Zhu, Yuxi, Morinibu, Akiyo, Kobayashi, Minoru, Shinomiya, Kazumi, Itasaka, Satoshi, Yoshimura, Michio, Guo, Guozheng, Hiraoka, Masahiro, Harada, Hiroshi

“…Hypoxia-inducible factor 1 (HIF-1) has been associated with distant tumor metastasis; however, its function in multiple metastatic processes has not yet been…”
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