Search Results - "Hara, Naofumi"

Selective C–O Bond Reduction and Borylation of Aryl Ethers Catalyzed by a Rhodium–Aluminum Heterobimetallic Complex by Seki, Rin, Hara, Naofumi, Saito, Teruhiko, Nakao, Yoshiaki

“…We report the catalytic reduction of a C–O bond and the borylation by a rhodium complex bearing an X-type PAlP pincer ligand. We have revealed the reaction…”
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C2-selective alkylation of pyridines by rhodium–aluminum complexes by Hara, Naofumi, Aso, Koki, Li, Qiao-Zhi, Sakaki, Shigeyoshi, Nakao, Yoshiaki

“…A C2- and mono-selective alkylation of various pyridines and azines with unactivated alkenes and vinylarenes using a heterobimetallic Rh–Al catalyst is…”
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Synthesis, Electronic Properties, and Lewis Acidity of Rhodium Complexes Bearing X-Type PBP, PAlP, and PGaP Pincer Ligands by Hara, Naofumi, Yamamoto, Konosuke, Tanaka, Yuuki, Saito, Teruhiko, Sakaki, Shigeyoshi, Nakao, Yoshiaki

“…We have synthesized rhodium complexes that bear X-type PBP and PGaP pincer ligands. X-ray diffraction analysis and IR spectroscopy of the PBP– and PGaP–Rh(CO)2…”
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VEGFR2 blockade augments the effects of tyrosine kinase inhibitors by inhibiting angiogenesis and oncogenic signaling in oncogene‐driven non‐small‐cell lung cancers by Watanabe, Hiromi, Ichihara, Eiki, Kayatani, Hiroe, Makimoto, Go, Ninomiya, Kiichiro, Nishii, Kazuya, Higo, Hisao, Ando, Chihiro, Okawa, Sachi, Nakasuka, Takamasa, Kano, Hirohisa, Hara, Naofumi, Hirabae, Atsuko, Kato, Yuka, Ninomiya, Takashi, Kubo, Toshio, Rai, Kammei, Ohashi, Kadoaki, Hotta, Katsuyuki, Tabata, Masahiro, Maeda, Yoshinobu, Kiura, Katsuyuki

“…Molecular agents targeting the epidermal growth factor receptor (EGFR)‐, anaplastic lymphoma kinase (ALK)‐ or c‐ros oncogene 1 (ROS1) alterations have…”
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Coordination Flexibility of the Rh(PXP) Complex to NH3, CO, and C2H4 (PXP = Diphosphine-Based Pincer Ligand; X = B, Al, and Ga): Theoretical Insight by Li, Qiao-Zhi, Hara, Naofumi, Nakao, Yoshiaki, Sakaki, Shigeyoshi

“…The recently synthesized rhodium–aluminum bimetallic complex Rh­(PAlP) 1 (PAlP = pincer-type diphosphino-aluminyl ligand Al­{[N­(C6H4)]2NMe}­[CH2P­( i Pr)2]2)…”
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Rh Complex with Unique Rh–Al Direct Bond: Theoretical Insight into its Characteristic Features and Application to Catalytic Reaction via σ-Bond Activation by Li, Qiao-Zhi, Hara, Naofumi, Semba, Kazuhiko, Nakao, Yoshiaki, Sakaki, Shigeyoshi

“…A new type of catalyst for reactions via σ-bond activation is Rh(PAlP): Rh-Al heterobimetallic complex of diphosphine-based tridentate pincer-type PAlP ligand…”
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Characteristics of patients with EGFR-mutant non-small-cell lung cancer who benefited from immune checkpoint inhibitors by Ichihara, Eiki, Harada, Daijiro, Inoue, Koji, Shibayama, Takuo, Hosokawa, Shinobu, Kishino, Daizo, Harita, Shingo, Ochi, Nobuaki, Oda, Naohiro, Hara, Naofumi, Hotta, Katsuyuki, Maeda, Yoshinobu, Kiura, Katsuyuki

“…Objectives Immune checkpoint inhibitors (ICIs) are less effective in non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor ( EGFR )…”
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Utility of immune checkpoint inhibitors in non‐small‐cell lung cancer patients with poor performance status by Kano, Hirohisa, Ichihara, Eiki, Harada, Daijiro, Inoue, Koji, Kayatani, Hiroe, Hosokawa, Shinobu, Kishino, Daizo, Watanabe, Kazuhiko, Ochi, Nobuaki, Oda, Naohiro, Hara, Naofumi, Ninomiya, Kiichiro, Hotta, Katsuyuki, Maeda, Yoshinobu, Kiura, Katsuyuki

“…Most clinical trials of non‐small‐cell lung cancer (NSCLC) exclude patients with poor ECOG performance status (PS). Thus, the efficacy of immune checkpoint…”
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Significance of PD-L1 expression in the cytological samples of non-small cell lung cancer patients treated with immune checkpoint inhibitors by Hara, Naofumi, Ichihara, Eiki, Harada, Daijiro, Inoue, Koji, Fujiwara, Keiichi, Hosokawa, Shinobu, Kishino, Daizo, Haruyuki, Kawai, Ochi, Nobuaki, Oda, Naohiro, Hotta, Katsuyuki, Maeda, Yoshinobu, Kiura, Katsuyuki

“…Objectives The programmed death-ligand 1 (PD-L1) tumor proportion score (TPS) in tumor tissue samples is an established clinical biomarker for non-small cell…”
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Palladium Complexes Bearing Z-type PAlP Pincer Ligands by Saito, Teruhiko, Hara, Naofumi, Nakao, Yoshiaki

“…Palladium complexes with pincer-type ligands containing a Z-type aluminum moiety are synthesized by the reaction of palladium(0) precursors with…”
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Nintedanib can be used safely and effectively for idiopathic pulmonary fibrosis with predicted forced vital capacity ≤ 50%: A multi-center retrospective analysis by Senoo, Satoru, Miyahara, Nobuaki, Taniguchi, Akihiko, Oda, Naohiro, Itano, Junko, Higo, Hisao, Hara, Naofumi, Watanabe, Hiromi, Kano, Hirohisa, Suwaki, Toshimitsu, Fuchimoto, Yasuko, Kajimoto, Kazuhiro, Ichikawa, Hirohisa, Kudo, Kenichiro, Shibayama, Takuo, Tanimoto, Yasushi, Kuyama, Shoichi, Kanehiro, Arihiko, Maeda, Yoshinobu, Kiura, Katsuyuki

“…Background Nintedanib is a multi-kinase inhibitor approved for idiopathic pulmonary fibrosis (IPF); however, its efficacy and safety for patients with IPF and…”
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Efficacy of afatinib treatment for lung adenocarcinoma harboring exon 18 delE709_T710insD mutation by Iwamoto, Yoshitaka, Ichihara, Eiki, Hara, Naofumi, Nakasuka, Takamasa, Ando, Chihiro, Umeno, Takahiro, Hirabae, Atsuko, Maeda, Yoshinobu, Kiura, Katsuyuki

“…Exon 18 delE709_T710insD is an extremely rare mutation in epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC); the efficacy of EGFR…”
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Impact of previous thoracsic radiation therapy on the efficacy of immune checkpoint inhibitors in advanced non-smasll-cell lung cancer by Hosokawa, Shinobu, Ichihara, Eiki, Bessho, Akihiro, Harada, Daijiro, Inoue, Koji, Shibayama, Takuo, Kishino, Daizo, Harita, Shingo, Ochi, Nobuaki, Oda, Naohiro, Hara, Naofumi, Hotta, Katsuyuki, Maeda, Yoshinobu, Kiura, Katsuyuki

“…Studies investigating the association between radiation therapy and the efficacy of immune checkpoint inhibitors in advanced non-small-cell lung cancer have…”
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The Rapid Appearance and Disappearance of Dendriform Pulmonary Ossification after Diffuse Alveolar Hemorrhage by Yamagishi, Tomoko, Fujimoto, Nobukazu, Miyamoto, Yosuke, Hara, Naofumi, Asano, Michiko, Fuchimoto, Yasuko, Wada, Sae, Kitamura, Kenichi, Ozaki, Shinji, Nishi, Hideyuki, Kishimoto, Takumi

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Angiosarcoma of the thoracic wall responded well to nanoparticle albumin-bound paclitaxel: A case report by Hara, Naofumi, Fujimoto, Nobukazu, Miyamoto, Yosuke, Yamagishi, Tomoko, Asano, Michiko, Fuchimoto, Yasuko, Wada, Sae, Ozaki, Shinji, Nishi, Hideyuki, Kishimoto, Takumi

“…An 81-year-old woman visited a local clinic due to chest pain and a skin induration on the right precordia. She had a history of right breast cancer, and she…”
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Lymphohistiocytoid Mesothelioma With Response to Chemotherapy by Miyamoto, Yosuke, MD, Fujimoto, Nobukazu, PhD, Hara, Naofumi, MD, Asano, Michiko, MD, Fuchimoto, Yasuko, PhD, Kitamura, Kenichi, PhD, Ozaki, Shinji, PhD, Kishimoto, Takumi, PhD

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Primary Effusion Lymphoma Developed in a Subject With Asbestos Exposure by Hara, Naofumi, MD, Fujimoto, Nobukazu, PhD, Miyamoto, Yosuke, MD, Asano, Michiko, MD, Fuchimoto, Yasuko, PhD, Kitamura, Kenichi, PhD, Ozaki, Shinji, MD, Kishimoto, Takumi, PhD

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Primary T-Cell Lymphoma of the Bronchus by Fuchimoto, Yasuko, PhD, Matsumoto, Shinsaku, MD, Asano, Michiko, MD, Hara, Naofumi, MD, Miyamoto, Yosuke, MD, Fujimoto, Nobukazu, PhD, Kitamura, Kenichi, PhD, Ozaki, Shinji, MD, Taguchi, Koji, PhD, Kishimoto, Takumi, PhD

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X‑Type Aluminyl Ligands for Transition-Metal Catalysis by Hara, Naofumi, Semba, Kazuhiko, Nakao, Yoshiaki

“…Transition-metal complexes that bear group-13 X-type metalloligands have attracted considerable interest on account of their strong σ-donicity, which can…”
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Lymphoproliferative disorder in pleural effusion in a subject with past asbestos exposure by Hara, Naofumi, Fujimoto, Nobukazu, Miyamoto, Yosuke, Yamagishi, Tomoko, Asano, Michiko, Fuchimoto, Yasuko, Wada, Sae, Ozaki, Shinji, Kishimoto, Takumi

“…Abstract Primary effusion lymphoma (PEL) is a subtype of non-Hodgkin lymphoma that presents as serous effusions without detectable masses or organomegaly. Here…”
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