Search Results - "Hara, Hiroshi"

Role of flavonoids in intestinal tight junction regulation by Suzuki, Takuya, Hara, Hiroshi

“…The gastrointestinal tract provides a physical barrier to the diffusion of foreign materials from the lumen into the circulatory system. Impairment of the…”
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Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability by Suzuki, Takuya, Yoshida, Shoko, Hara, Hiroshi

“…Colonic fermentation products, SCFA, have various effects on colonic functions. Here, we found that physiological concentrations of SCFA immediately promote…”
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Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats by Suzuki, Takuya, Hara, Hiroshi

“…Background: An increase in the intestinal permeability is considered to be associated with the inflammatory tone and development in the obesity and diabetes,…”
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Improvement of Glucose Tolerance by Food Factors Having Glucagon-Like Peptide-1 Releasing Activity by Hira, Tohru, Trakooncharoenvit, Aphichat, Taguchi, Hayate, Hara, Hiroshi

“…Glucagon-like peptide-1 (GLP-1) is a gastrointestinal hormone released from enteroendocrine L cells in response to meal ingestion. GLP-1 receptor agonists and…”
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Kaempferol enhances intestinal barrier function through the cytoskeletal association and expression of tight junction proteins in Caco-2 cells by Suzuki, Takuya, Tanabe, Soichi, Hara, Hiroshi

“…Kaempferol, a natural flavonoid present in fruits, vegetables, and teas, provides beneficial effects for human health. We investigated the promotive effect of…”
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Silica removal at sewage treatment plants causes new silica deficiency by Kubo, Atsushi, Kawarasaki, Koki, Hara, Hiroshi

“…The dissolved silicate (DSi) concentration in coastal waters has decreased due to anthropogenic activities. Many studies have indicated that dam construction…”
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A global assessment of precipitation chemistry and deposition of sulfur, nitrogen, sea salt, base cations, organic acids, acidity and pH, and phosphorus by Vet, Robert, Artz, Richard S., Carou, Silvina, Shaw, Mike, Ro, Chul-Un, Aas, Wenche, Baker, Alex, Bowersox, Van C., Dentener, Frank, Galy-Lacaux, Corinne, Hou, Amy, Pienaar, Jacobus J., Gillett, Robert, Forti, M. Cristina, Gromov, Sergey, Hara, Hiroshi, Khodzher, Tamara, Mahowald, Natalie M., Nickovic, Slobodan, Rao, P.S.P., Reid, Neville W.

“…A global assessment of precipitation chemistry and deposition has been carried out under the direction of the World Meteorological Organization (WMO) Global…”
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GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose by Iwasaki, Yusaku, Sendo, Mio, Dezaki, Katsuya, Hira, Tohru, Sato, Takehiro, Nakata, Masanori, Goswami, Chayon, Aoki, Ryohei, Arai, Takeshi, Kumari, Parmila, Hayakawa, Masaki, Masuda, Chiaki, Okada, Takashi, Hara, Hiroshi, Drucker, Daniel J., Yamada, Yuichiro, Tokuda, Masaaki, Yada, Toshihiko

“…Overeating and arrhythmic feeding promote obesity and diabetes. Glucagon-like peptide-1 receptor (GLP-1R) agonists are effective anti-obesity drugs but their…”
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Lipid domains in bacterial membranes by Matsumoto, Kouji, Kusaka, Jin, Nishibori, Ayako, Hara, Hiroshi

“…Summary The recent development of specific probes for lipid molecules has led to the discovery of lipid domains in bacterial membranes, that is, of membrane…”
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Casein materials show different digestion patterns using an in vitro gastrointestinal model and different release of glucagon-like peptide-1 by enteroendocrine GLUTag cells by Komatsu, Yosuke, Wada, Yasuaki, Izumi, Hirohisa, Shimizu, Takashi, Takeda, Yasuhiro, Hira, Tohru, Hara, Hiroshi

“…•Properties of casein materials depend on the production process.•Micellar casein concentrate has higher digestibility than sodium caseinate.•Both casein…”
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Oral Administration of Corn Zein Hydrolysate Stimulates GLP-1 and GIP Secretion and Improves Glucose Tolerance in Male Normal Rats and Goto-Kakizaki Rats by Higuchi, Noriyuki, Hira, Tohru, Yamada, Nao, Hara, Hiroshi

“…We have previously demonstrated that ileal administration of the dietary protein hydrolysate prepared from corn zein (ZeinH) stimulated glucagon-like peptide-1…”
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Postprandial glucagon-like peptide-1 secretion is increased during the progression of glucose intolerance and obesity in high-fat/high-sucrose diet-fed rats by Nakajima, Shingo, Hira, Tohru, Hara, Hiroshi

“…Glucagon-like peptide-1 (GLP-1) is secreted by distal enteroendocrine cells in response to luminal nutrients, and exerts insulinotropic and anorexigenic…”
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Canagliflozin potentiates GLP-1 secretion and lowers the peak of GIP secretion in rats fed a high-fat high-sucrose diet by Hira, Tohru, Koga, Toshiki, Sasaki, Kazuyo, Hara, Hiroshi

“…The glucose-induced secretion of incretins, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), is dependent on…”
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Wheat gluten hydrolysate potently stimulates peptide-YY secretion and suppresses food intake in rats by Chen, Wenya, Hira, Tohru, Nakajima, Shingo, Hara, Hiroshi

“…The study was aimed to compare the satiating effect of various protein hydrolysates in rats and examine the underlying mechanism associated with the satiety…”
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Voluntary Running Exercise Alters Microbiota Composition and Increases n-Butyrate Concentration in the Rat Cecum by MATSUMOTO, Megumi, INOUE, Ryo, TSUKAHARA, Takamitsu, USHIDA, Kazunari, CHIJI, Hideyuki, MATSUBARA, Noritaka, HARA, Hiroshi

“…The effects of voluntary wheel-running exercise on cecal microbiota and short-chain fatty acid production were investigated in rats. The microbiota composition…”
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Improved analysis of bile acids in tissues and intestinal contents of rats using LC/ESI-MS by Hagio, Masahito, Matsumoto, Megumi, Fukushima, Michihiro, Hara, Hiroshi, Ishizuka, Satoshi

“…To evaluate bile acid (BA) metabolism in detail, we established a method for analyzing BA composition in various tissues and intestinal contents using ultra…”
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Water-soluble dietary fibers enhance bioavailability of quercetin and a fiber derived from soybean is most effective after long-term feeding in rats by Trakooncharoenvit, Aphichat, Tanaka, Seiya, Mizuta, Erika, Hira, Tohru, Hara, Hiroshi

“…Purpose To investigate the effects of water-soluble dietary fibers (pectin, soybean fiber, and guar gum) on the bioavailability of quercetin glucoside mixture…”
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Glucolipids and lipoteichoic acids affect the activity of SigI, an alternative sigma factor, and WalKR, an essential two‐component system, in Bacillus subtilis by Matsuoka, Satoshi, Shimizu, Yoko, Nobe, Kaori, Matsumoto, Kouji, Asai, Kei, Hara, Hiroshi

“…In a Bacillus subtilis ugtP mutant lacking glucolipids, SigI was activated in the log phase, and the activation of SigI in the mutant was suppressed by the…”
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Simultaneous collection of the portal and superior vena cava blood in conscious rats defined that intestinal epithelium is the major site of glucuronidation, but not sulfation and methylation, of quercetin by Tanaka, Seiya, Oyama, Manami, Nishikawa, Miyu, Ikushiro, Shinichi, Hara, Hiroshi

“…Quercetin is a flavonoid with many physiological effects. Absorbed quercetin is rapidly conjugated in the intestinal epithelium and liver. Different positional…”
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GLP-1 secretion is enhanced directly in the ileum but indirectly in the duodenum by a newly identified potent stimulator, zein hydrolysate, in rats by Hira, Tohru, Mochida, Taisuke, Miyashita, Kyoko, Hara, Hiroshi

“…Glucagon-like peptide-1 (GLP-1) is released from enteroendocrine cells (L cells) in response to food ingestion. The mechanism by which dietary peptides…”
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