Search Results - "Haque, S J"

Human Airway Epithelial Cell Determinants of Survival and Functional Phenotype for Primary Human Mast Cells by Hsieh, F. H., Sharma, P., Gibbons, A., Goggans, T., Erzurum, S. C., Haque, S. J., Austen, K. Frank

“…Mast cells (MCs) are found in increased numbers at airway mucosal surfaces in asthmatic patients. Because human airway epithelial cells (HAECs) actively…”
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Signal transduction in the interferon system by Haque, S J, Williams, B R

“…Interferons (IFNs) comprise a family of secreted proteins that function as important biologic response modifiers in vertebrates. Interferons are produced in…”
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Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators by Guo, F H, Uetani, K, Haque, S J, Williams, B R, Dweik, R A, Thunnissen, F B, Calhoun, W, Erzurum, S C

“…Human respiratory epithelium expresses inducible nitric oxide synthase (iNOS) continuously in vivo, however mechanisms responsible for maintenance of…”
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Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells by SHAIK OHIDAR RAHAMAN, HARBOR, Phyllis C, CHERNOVA, Olga, BARNETT, Gene H, VOGELBAUM, Michael A, JAHARUL HAQUE, S

“…Glioblastoma multiforme (GBM), the most common and malignant central nervous system tumor in humans, is highly proliferative and resistant to apoptosis. Stat3,…”
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Identification and characterization of an interferon (IFN)-stimulated response element-IFN-stimulated gene factor 3-independent signaling pathway for IFN-alpha by JAHARUL HAQUE, S, WILLIAMS, B. R. G

“…Transcriptional activation of genes containing the interferon (IFN)-stimulated response element (ISRE) by IFN-alpha is known to be mediated through the…”
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p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons by Goh, Kee Chuan, Haque, S.Jaharul, Williams, Bryan R.G.

“…Activation of cytosolic phospholipase A2 (cPLA2) is a prerequisite for the formation of the transcription factor complex interferon‐stimulated gene factor 3…”
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RNA-dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1-independent pathway by Deb, A, Haque, S J, Mogensen, T, Silverman, R H, Williams, B R

“…The IFN-inducible dsRNA-activated protein kinase PKR regulates protein synthesis through phosphorylation of eukaryotic initiation factor-2alpha. It also acts…”
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Impaired Innate Host Defense Causes Susceptibility to Respiratory Virus Infections in Cystic Fibrosis by Zheng, Shuo, De, Bishnu P, Choudhary, Suresh, Comhair, Suzy A.A, Goggans, Tannishia, Slee, Roger, Williams, Bryan R.G, Pilewski, Joseph, Haque, S.Jaharul, Erzurum, Serpil C

“…Viral infection is the primary cause of respiratory morbidity in cystic fibrosis (CF) infants. Here, we identify that host factors allow increased virus…”
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PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells by GHOSH, Mrinal K, SHARMA, Pankaj, HARBOR, Phyllis C, RAHAMAN, Shaik O, HAQUE, S. Jaharul

“…Glioblastoma multiforme (GBM) cells frequently harbor amplification and/or gain-of-function mutation of the EGFR gene leading to the activation of multiple…”
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The possible role of TGF-beta-induced suppressors of cytokine signaling expression in osteoclast/macrophage lineage commitment in vitro by Fox, Simon W, Haque, S Jaharul, Lovibond, Alison C, Chambers, Timothy J

“…Osteoclast formation is dependent on the ability of TGF-beta to enable receptor activator of NF-kappaB ligand (RANKL)-induced commitment of hemopoietic…”
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Protein-tyrosine Phosphatase Shp-1 Is a Negative Regulator of IL-4- and IL-13-dependent Signal Transduction by Haque, S J, Harbor, P, Tabrizi, M, Yi, T, Williams, B R

“…Binding of interleukin (IL)-4 to its transmembrane receptor results in the Jak-mediated tyrosine phosphorylation of a number of protein components of the IL-4…”
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Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1 by Zhuang, Dazhong, Qiu, Yaling, Haque, S. Jaharul, Dong, Fan

“…Mutations in the granulocyte‐colony stimulating factor receptor (G‐CSF‐R) gene resulting in carboxy terminal truncation have been associated with acute myeloid…”
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In vivo and in vitro effects of kalmegh (Andrographis paniculata) extract and andrographolide on hepatic microsomal drug metabolizing enzymes by Choudhury, B R, Haque, S J, Poddar, M K

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TGF-β-induced SOCS3 expression augments TNF-α-induced osteoclast formation by Lovibond, Alison C, Haque, S.Jaharul, Chambers, Timothy J, Fox, Simon W

“…Osteoclast differentiation is dependent on TGF-β to prime precursors to the osteoclast lineage. The mechanism by which TGF-β enables osteoclast formation is…”
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Identification of critical residues required for suppressor of cytokine signaling-specific regulation of interleukin-4 signaling by Haque, S J, Harbor, P C, Williams, B R

“…Suppressor of cytokine signaling (SOCS) family proteins were originally identified as cytokine-induced negative regulators of cytokine signaling. We show that…”
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Interferon‐alpha‐induced phosphorylation and activation of cytosolic phospholipase A2 is required for the formation of interferon‐stimulated gene factor three by Flati, V., Haque, S. J., Williams, B. R.

“…Treatment of cells with interferon (IFN)‐alpha caused phosphorylation and activation of cytosolic phospholipase A2 (cPLA2). The protein tyrosine kinase Jak1…”
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Roles of Protein-tyrosine Phosphatases in Stat1α-mediated Cell Signaling (∗) by Haque, S. Jaharul, Flati, Vincenzo, Deb, Amitabha, Williams, Bryan R.G.

“…Different Stat proteins are activated through phosphorylation of unique tyrosine residues in response to different cytokines and growth factors. Interferon-γ…”
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Targeting TRIBBLES1 (TRIB1) Pseudokinase as a New Therapeutic Approach in GBM by Singh, K., Han, C., Fleming, J.L., McElroy, J., Bell, E.H., Robe, P., Haque, S.J., Chakravarti, A.

“…Glioblastoma (GBM) (WHO grade IV) is the most aggressive form of glioma with a 5-year survival rate of 5%. The current therapeutic regimen involves maximal…”
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Serine phosphorylation of Stat6 negatively controls its DNA-binding function by Maiti, Nilesh R, Sharma, Pankaj, Harbor, Phyllis C, Haque, S Jaharul

“…In response to interleukin-4 (IL-4) or IL-13 stimulation of cells, Stat6 becomes phosphorylated on Tyr(641) and forms homodimers that migrate to the nucleus,…”
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In-Silico Discovery of Novel Small-Molecule Inhibitors Targeting Transgelin-2-Actin Interaction Inhibits Proliferation, Invasion and Improves Chemo-Radiation Response in Human Glioblastoma by Kumar, A., Rajasekera, P., Biehn, S., Beyer, S., McElroy, J., Becker, A., Johnson, B., Cui, T., Sebastian, E., Grosu, A., Lindert, S., Bell, E.H., Haque, S.J., Chakravarti, A.

“…Transgelin-2 (TAGLN2) is an oncogene and actin-binding protein known to induce actin polymerization, thereby playing a critical role in cell proliferation,…”
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