Search Results - "Haque, M. Emdadul"

Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease by Javed, Hayate, Azimullah, Sheikh, Haque, M Emdadul, Ojha, Shreesh K

“…The cannabinoid type two receptors (CB2), an important component of the endocannabinoid system, have recently emerged as neuromodulators and therapeutic…”
Get full text

Parkinson's Disease: Exploring Different Animal Model Systems by Khan, Engila, Hasan, Ikramul, Haque, M Emdadul

“…Disease modeling in non-human subjects is an essential part of any clinical research. To gain proper understanding of the etiology and pathophysiology of any…”
Get full text

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment by Greene, Andrew W, Grenier, Karl, Aguileta, Miguel A, Muise, Stephanie, Farazifard, Rasoul, Haque, M Emdadul, McBride, Heidi M, Park, David S, Fon, Edward A

“…Mutations in phosphatase and tensin homologue‐induced kinase 1 (PINK1) cause recessively inherited Parkinson's disease (PD), a neurodegenerative disorder…”
Get full text

Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone by Javed, Hayate, Azimullah, Sheikh, Abul Khair, Salema B, Ojha, Shreesh, Haque, M Emdadul

“…Parkinson disease (PD) is a movement disorder affecting 1 % of people over the age of 60. The etiology of the disease is unknown; however, accumulating…”
Get full text

History of Parkinson's Disease-Associated Gene, Parkin : Research over a Quarter Century in Quest of Finding the Physiological Substrate by Kitada, Tohru, Ardah, Mustafa T, Haque, M Emdadul

“…, the gene responsible for hereditary Parkinson's disease (PD) called "Autosomal Recessive Juvenile Parkinsonism (AR-JP)" was discovered a quarter of a century…”
Get full text

Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy by Ardah, Mustafa T, Eid, Nabil, Kitada, Tohru, Haque, M Emdadul

“…Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopamine neurons and the deposition of misfolded proteins known as Lewy…”
Get full text

Ellagic Acid Prevents Dopamine Neuron Degeneration from Oxidative Stress and Neuroinflammation in MPTP Model of Parkinson's Disease by Ardah, Mustafa T, Bharathan, Greeshma, Kitada, Tohru, Haque, M Emdadul

“…Parkinson's disease (PD) is one of the most common neurodegenerative diseases and is characterized by progressive dopaminergic neurodegeneration in the…”
Get full text

Longitudinal changes in CSF alpha-synuclein species reflect Parkinson's disease progression by Majbour, Nour K., Vaikath, Nishant N., Eusebi, Paolo, Chiasserini, Davide, Ardah, Mustafa, Varghese, Shiji, Haque, M. Emdadul, Tokuda, Takahiko, Auinger, Peggy, Calabresi, Paolo, Parnetti, Lucilla, El-Agnaf, Omar M.A.

“…ABSTRACT Background Parkinson's disease (PD) diagnosis is mainly based on clinical criteria, with a high risk of misdiagnosis. The identification of reliable…”
Get full text

Parkin Precipitates on Mitochondria via Aggregation and Autoubiquitination by Ardah, Mustafa T, Radwan, Nada, Khan, Engila, Kitada, Tohru, Haque, M Emdadul

“…The loss of the E3 ligase Parkin, in a familial form of Parkinson's disease, is thought to cause the failure of both the polyubiquitination of abnormal…”
Get full text

Ellagic Acid Prevents α-Synuclein Spread and Mitigates Toxicity by Enhancing Autophagic Flux in an Animal Model of Parkinson's Disease by Radwan, Nada, Khan, Engila, Ardah, Mustafa T, Kitada, Tohru, Haque, M Emdadul

“…Parkinson's disease (PD) is the second most common neurological disorder, pathologically characterized by loss of dopaminergic neurons in the substantia nigra…”
Get full text

ATP13A2 Gene Silencing in Drosophila Affects Autophagic Degradation of A53T Mutant α-Synuclein by Dhanushkodi, Nisha R, Abul Khair, Salema B, Ardah, Mustafa T, Haque, M Emdadul

“…Mutations in ( ), an autophagy-related protein, cause Kufor-Rakeb syndrome, an autosomal recessive, juvenile-onset form of parkinsonism. α-Synuclein (α-syn) is…”
Get full text

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP by Haque, M. Emdadul, Thomas, Kelly J, D'Souza, Cheryl, Callaghan, Steve, Kitada, Tohru, Slack, Ruth S, Fraser, Paul, Cookson, Mark R, Tandon, Anurag, Park, David S

“…PTEN-induced putative kinase 1 (Pink1) is a recently identified gene linked to a recessive form of familial Parkinson's disease (PD). The kinase contains a…”
Get full text

Cryo-EM structure of the small subunit of the mammalian mitochondrial ribosome by Kaushal, Prem S., Sharma, Manjuli R., Booth, Timothy M., Haque, Emdadul M., Tung, Chang-Shung, Sanbonmatsu, Karissa Y., Spremulli, Linda L., Agrawal, Rajendra K.

“…The mammalian mitochondrial ribosomes (mitoribosomes) are responsible for synthesizing 13 membrane proteins that form essential components of the complexes…”
Get full text

Attenuation of epigenetic regulator SMARCA4 and ERK‐ETS signaling suppresses aging‐related dopaminergic degeneration by Sun, Ling, Zhang, Jie, Chen, Wenfeng, Chen, Yun, Zhang, Xiaohui, Yang, Mingjuan, Xiao, Min, Ma, Fujun, Yao, Yizhou, Ye, Meina, Zhang, Zhenkun, Chen, Kai, Chen, Fei, Ren, Yujun, Ni, Shiwei, Zhang, Xi, Yan, Zhangming, Sun, Zhi‐Rong, Zhou, Hai‐Meng, Yang, Hongqin, Xie, Shusen, Haque, M. Emdadul, Huang, Kun, Yang, Yufeng

“…How complex interactions of genetic, environmental factors and aging jointly contribute to dopaminergic degeneration in Parkinson's disease (PD) is largely…”
Get full text

The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death by Haque, M. Emdadul, Woulfe, John M, Slack, Ruth S, Rousseaux, Maxime W.C, Park, David S, Qu, Dianbo, Zhang, Yi, Huang, En, Venderova, Katerina

“…Cyclin-dependent kinase 5 phosphorylates Ape1, a regulator of base excision repair, to reduce its endonuclease activity and increase neuronal death following…”
Get full text

Silencing of Glucocerebrosidase Gene in Drosophila Enhances the Aggregation of Parkinson's Disease Associated α-Synuclein Mutant A53T and Affects Locomotor Activity by Abul Khair, Salema B, Dhanushkodi, Nisha R, Ardah, Mustafa T, Chen, Wenfeng, Yang, Yufeng, Haque, M Emdadul

“…Mutations in glucocerebrosidase (GBA), a lysosomal enzyme are the most common genetic risk factor for developing Parkinson's disease (PD). We studied how…”
Get full text

β-Caryophyllene, a phytocannabinoid attenuates oxidative stress, neuroinflammation, glial activation, and salvages dopaminergic neurons in a rat model of Parkinson disease by Ojha, Shreesh, Javed, Hayate, Azimullah, Sheikh, Haque, M. Emdadul

“…Parkinson disease (PD) is a neurodegenerative disease characterized by progressive dopaminergic neurodegeneration in the substantia nigra pars compacta (SNc)…”
Get full text

Thymoquinone prevents neurodegeneration against MPTP in vivo and modulates α-synuclein aggregation in vitro by Ardah, Mustafa T., Merghani, Madiha Mohieldin, Haque, M. Emdadul

“…Parkinson's disease (PD) is a common neurodegenerative disease characterized by progressive dopaminergic neurodegeneration with a concomitant increase in…”
Get full text

Apoptosis-inducing neurotoxicity of dopamine and its metabolites via reactive quinone generation in neuroblastoma cells by Emdadul Haque, M, Asanuma, Masato, Higashi, Youichirou, Miyazaki, Ikuko, Tanaka, Ken-ichi, Ogawa, Norio

“…Neurotoxic properties of l-dopa and dopamine (DA)-related compounds were assessed in human neuroblastoma SH-SY5Y cells with reference to their structural…”
Get full text

Dose-related biphasic effect of the Parkinson’s disease neurotoxin MPTP, on the spread, accumulation, and toxicity of α-synuclein by Merghani, Madiha Mohieldin, Ardah, Mustafa T., Al Shamsi, Mariam, Kitada, Tohru, Haque, M. Emdadul

“…•Single injection of α-syn PFF in the mice striatum induced the spreading of α-syn.•Low dose of MPTP (10 mg/kg.b.wt) further enhanced this spreading and…”
Get full text