pH and Salt Responsive Hydrogel based on Guar Gum as a Renewable Material for Delivery of Curcumin: A Natural Anti-Cancer Drug

pH and Salt Responsive Hydrogel based on Guar Gum as a Renewable Material for Delivery of Curcumin: A Natural Anti-Cancer Drug

The manuscript represents synthesis of pH and salt responsive hydrogel based on guar gum as a renewable substrate for drug delivery of natural anticancer drug i.e. curcumin. Initially acrylic acid grafted guar gum (GG-g-PAA) hydrogel was obtained in the presence of ammonium persulphate as a redox in...

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Bibliographic Details
Published in:Journal of polymers and the environment Vol. 29; no. 6; pp. 1978 - 1989
Main Authors: HaqAsif, Afzal, Karnakar, Rahul R., Sreeharsha, Nagaraja, Gite, Vikas V., Borane, Niteen, Al-Dhubiab, Bandar E., Kaliyadan, Feroze, Rasool, Tasleem, Nanjappa, Shivakumar H., Meravanige, Girish
Format: Journal Article
Language:English
Published: New York Springer US 01-06-2021
Springer Nature B.V
Subjects:
Acrylic acid
Ammonium
Antitumor agents
Aqueous solutions
Cancer
Chemistry
Chemistry and Materials Science
Copolymers
Curcumin
Drug delivery
Drug delivery systems
Environmental Chemistry
Environmental Engineering/Biotechnology
Graft copolymers
Guar gum
Hydrogels
Industrial Chemistry/Chemical Engineering
Materials Science
Methylene bisacrylamide
NMR
Nuclear magnetic resonance
Original Paper
pH effects
Polymer Sciences
Salts
Structural stability
Substrates
Drug delivery
Curcumin
Anti-cancer
Hydrogel
Acrylic acid
Guar gum
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Summary:The manuscript represents synthesis of pH and salt responsive hydrogel based on guar gum as a renewable substrate for drug delivery of natural anticancer drug i.e. curcumin. Initially acrylic acid grafted guar gum (GG-g-PAA) hydrogel was obtained in the presence of ammonium persulphate as a redox initiator. Structural stability of grafted copolymer was improved using N, N-methylenebisacrylamide as a crosslinker with simultaneous loading of curcumin as a natural anticancer drug. Delivery rate of curcumin from GG-g-PAA was studied by UV spectrophotometer. The neat and drug loaded hydrogels were characterized using FTIR, NMR, TGA, and SEM techniques for their structural, morphological, and thermal behaviours. Swelling of the hydrogels and water diffusion properties were studied in salt and aqueous solutions of different pH. Finally, the fabricated hydrogel matrices were tested for curcumin release studies to understand the release kinetic. The results indicated that the prepared renewable source based hydrogel can be used in drug delivery of curcumin as a natural medicine. As curcumin and guar gum are products of agricultural food crops viz . turmeric and guar, the current research can be a good contribution towards preparation of an eco-friendly drug delivery system based on agriculture products. Graphic Abstract
ISSN:1566-2543
1572-8919
DOI:10.1007/s10924-020-01934-1