Search Results - "Happle, Christine"

COVID-19 related reduction in pediatric emergency healthcare utilization - a concerning trend by Dopfer, Christian, Wetzke, Martin, Zychlinsky Scharff, Anna, Mueller, Frank, Dressler, Frank, Baumann, Ulrich, Sasse, Michael, Hansen, Gesine, Jablonka, Alexandra, Happle, Christine

“…The COVID-19 pandemic has disrupted healthcare systems worldwide. In addition to the direct impact of the virus on patient morbidity and mortality, the effect…”
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Chimeric Antigen Receptor-Redirected Regulatory T Cells Suppress Experimental Allergic Airway Inflammation, a Model of Asthma by Skuljec, Jelena, Chmielewski, Markus, Happle, Christine, Habener, Anika, Busse, Mandy, Abken, Hinrich, Hansen, Gesine

“…Cellular therapy with chimeric antigen receptor (CAR)-redirected cytotoxic T cells has shown impressive efficacy in the treatment of hematologic malignancies…”
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Perceived versus proven SARS-CoV-2-specific immune responses in health-care professionals by Behrens, Georg M. N., Cossmann, Anne, Stankov, Metodi V., Witte, Torsten, Ernst, Diana, Happle, Christine, Jablonka, Alexandra

“…There have been concerns about high rates of thus far undiagnosed SARS-CoV-2 infections in the health-care system. The COVID-19 Contact (CoCo) Study follows…”
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Pulmonary Transplantation of Human Induced Pluripotent Stem Cell-derived Macrophages Ameliorates Pulmonary Alveolar Proteinosis by Happle, Christine, Lachmann, Nico, Ackermann, Mania, Mirenska, Anja, Göhring, Gudrun, Thomay, Kathrin, Mucci, Adele, Hetzel, Miriam, Glomb, Torsten, Suzuki, Takuji, Chalk, Claudia, Glage, Silke, Dittrich-Breiholz, Oliver, Trapnell, Bruce, Moritz, Thomas, Hansen, Gesine

“…Although the transplantation of induced pluripotent stem cell (iPSC)-derived cells harbors enormous potential for the treatment of pulmonary diseases, in vivo…”
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IL‐17 regulates DC migration to the peribronchial LNs and allergen presentation in experimental allergic asthma by Jirmo, Adan Chari, Busse, Mandy, Happle, Christine, Skuljec, Jelena, Dalüge, Kathleen, Habener, Anika, Grychtol, Ruth, DeLuca, David S., Breiholz, Oliver D., Prinz, Immo, Hansen, Gesine

“…IL‐17 is associated with different phenotypes of asthma, however, it is not fully elucidated how it influences induction and maintenance of asthma and allergy…”
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Large-Scale Hematopoietic Differentiation of Human Induced Pluripotent Stem Cells Provides Granulocytes or Macrophages for Cell Replacement Therapies by Lachmann, Nico, Ackermann, Mania, Frenzel, Eileen, Liebhaber, Steffi, Brennig, Sebastian, Happle, Christine, Hoffmann, Dirk, Klimenkova, Olga, Lüttge, Doreen, Buchegger, Theresa, Kühnel, Mark Philipp, Schambach, Axel, Janciauskiene, Sabina, Figueiredo, Constanca, Hansen, Gesine, Skokowa, Julia, Moritz, Thomas

“…Interleukin-3 (IL-3) is capable of supporting the proliferation of a broad range of hematopoietic cell types, whereas granulocyte colony-stimulating factor…”
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Humoral and Cellular Immune Responses Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants and Human Coronaviruses After Single BNT162b2 Vaccination by Stankov, Metodi V, Cossmann, Anne, Bonifacius, Agnes, Dopfer-Jablonka, Alexandra, Ramos, Gema Morillas, Gödecke, Nina, Scharff, Anna Zychlinsky, Happle, Christine, Boeck, Anna-Lena, Tran, Anh Thu, Pink, Isabell, Hoeper, Marius M, Blasczyk, Rainer, Winkler, Martin S, Nehlmeier, Inga, Kempf, Amy, Hofmann-Winkler, Heike, Hoffmann, Markus, Eiz-Vesper, Britta, Pöhlmann, Stefan, Behrens, Georg M N

“…Vaccine-induced neutralizing antibodies are key in combating the coronavirus disease 2019 (COVID-19) pandemic. However, delays of boost immunization due to…”
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Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis by Happle, Christine, Lachmann, Nico, Škuljec, Jelena, Wetzke, Martin, Ackermann, Mania, Brennig, Sebastian, Mucci, Adele, Jirmo, Adan Chari, Groos, Stephanie, Mirenska, Anja, Hennig, Christina, Rodt, Thomas, Bankstahl, Jens P, Schwerk, Nicolaus, Moritz, Thomas, Hansen, Gesine

“…Hereditary pulmonary alveolar proteinosis (herPAP) is a rare lung disease caused by mutations in the granulocyte-macrophage colony-stimulating factor (GM-CSF)…”
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Common variants at ten loci modulate the QT interval duration in the QTSCD Study by Najjar, Samer S, Fuchsberger, Christian, Pütz, Benno, Perz, Siegfried, Crisponi, Laura, Steinbeck, Gerhard, Ehret, Georg B, Hicks, Andrew A, Sinner, Moritz F, Orrú, Marco, Köttgen, Anna, Marroni, Fabio, Müller, Martina, Usala, Gianluca, Kao, W H Linda, Pramstaller, Peter P, Kääb, Stefan, Gieger, Christian, Li, Man, Scuteri, Angelo, Uda, Manuela, Barbalic, Maja, Gateva, Vesela, Pattaro, Cristian, Erbel, Raimund, Sanna, Serena, Möhlenkamp, Stefan, Dei, Mariano, Wichmann, H-Erich, Meitinger, Thomas, Chakravarti, Aravinda, Abecasis, Gonçalo R, Lakatta, Edward, Schlessinger, David, Pfeufer, Arne, Jöckel, Karl-Heinz, Müller-Myhsok, Bertram, Boerwinkle, Eric, Arking, Dan E, Prineas, Ronald J, Mühleisen, Thomas W, Naitza, Silvia, Coresh, Josef, Happle, Christine

“…Arne Pfeufer, Aravinda Chakravarti and colleagues from the QTSCD consortium report genetic associations influencing the QT interval duration, a measure of…”
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IL-27 Is Essential for Suppression of Experimental Allergic Asthma by the TLR7/8 Agonist R848 (Resiquimod) by Jirmo, Adan Chari, Daluege, Kathleen, Happle, Christine, Albrecht, Melanie, Dittrich, Anna-Maria, Busse, Mandy, Habener, Anika, Skuljec, Jelena, Hansen, Gesine

“…Different models of experimental allergic asthma have shown that the TLR7/8 agonist resiquimod (R848) is a potential inhibitor of type 2 helper cell-driven…”
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Tuberculosis screening during the 2015 European refugee crisis by Tewes, Susanne, Hensen, Bennet, Jablonka, Alexandra, Gawe, Dana, Kastikainen, Maija, Happle, Christine, Carlens, Julia, Berthold, Lars-Daniel, Wacker, Frank

“…The purpose of our study was to describe and evaluate management, performance and results of Tuberculosis (TB)-screening among refugees and asylum seekers in a…”
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Gene correction of human induced pluripotent stem cells repairs the cellular phenotype in pulmonary alveolar proteinosis by Lachmann, Nico, Happle, Christine, Ackermann, Mania, Lüttge, Doreen, Wetzke, Martin, Merkert, Sylvia, Hetzel, Miriam, Kensah, George, Jara-Avaca, Monica, Mucci, Adele, Skuljec, Jelena, Dittrich, Anna-Maria, Pfaff, Nils, Brennig, Sebastian, Schambach, Axel, Steinemann, Doris, Göhring, Gudrun, Cantz, Tobias, Martin, Ulrich, Schwerk, Nicolaus, Hansen, Gesine, Moritz, Thomas

“…Hereditary pulmonary alveolar proteinosis (hPAP) caused by granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor α-chain (CSF2RA) deficiency is a…”
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Single cell RNA sequencing reveals distinct clusters of Irf8-expressing pulmonary conventional dendritic cells by Jirmo, Adan Chari, Grychtol, Ruth, Gaedcke, Svenja, Liu, Bin, DeStefano, Stephanie, Happle, Christine, Halle, Olga, Monteiro, Joao T, Habener, Anika, Breiholz, Oliver D, DeLuca, David, Hansen, Gesine

“…A single population of interferon-regulatory factor 8 (Irf8)-dependent conventional dendritic cell (cDC type1) is considered to be responsible for both…”
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The all age asthma cohort (ALLIANCE) - from early beginnings to chronic disease: a longitudinal cohort study by Fuchs, Oliver, Bahmer, Thomas, Weckmann, Markus, Dittrich, Anna-Maria, Schaub, Bianca, Rösler, Barbara, Happle, Christine, Brinkmann, Folke, Ricklefs, Isabell, König, Inke R, Watz, Henrik, Rabe, Klaus F, Kopp, Matthias V, Hansen, Gesine, von Mutius, Erika

“…Asthma and wheezing disorders in childhood and adulthood are clinically heterogeneous regarding disease presentation, natural course, and response to…”
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Promoter and lineage independent anti-silencing activity of the A2 ubiquitous chromatin opening element for optimized human pluripotent stem cell-based gene therapy by Ackermann, Mania, Lachmann, Nico, Hartung, Susann, Eggenschwiler, Reto, Pfaff, Nils, Happle, Christine, Mucci, Adele, Göhring, Gudrun, Niemann, Heiner, Hansen, Gesine, Schambach, Axel, Cantz, Tobias, Zweigerdt, Robert, Moritz, Thomas

“…Abstract Epigenetic silencing of retroviral transgene expression in pluripotent stem cells (PSC) and their differentiated progeny constitutes a major roadblock…”
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Phenotypic spectrum in recessive STING-associated vasculopathy with onset in infancy: Four novel cases and analysis of previously reported cases by Wan, Rensheng, Fänder, Johannes, Zakaraia, Ia, Lee-Kirsch, Min Ae, Wolf, Christine, Lucas, Nadja, Olfe, Lisa Isabel, Hendrich, Corinna, Jonigk, Danny, Holzinger, Dirk, Steindor, Mathis, Schmidt, Gunnar, Davenport, Claudia, Klemann, Christian, Schwerk, Nicolaus, Griese, Matthias, Schlegelberger, Brigitte, Stehling, Florian, Happle, Christine, Auber, Bernd, Steinemann, Doris, Wetzke, Martin, von Hardenberg, Sandra

“…Gain-of-function variants in the stimulator of interferon response cGAMP interactor 1 ( STING1 ) gene cause STING-Associated Vasculopathy with onset in Infancy…”
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B cells control maternofetal priming of allergy and tolerance in a murine model of allergic airway inflammation by Happle, Christine, MD/PhD, Jirmo, Adan Chari, PhD, Meyer-Bahlburg, Almut, MD, Habener, Anika, PhD, Hoymann, Heinz Gerd, PhD, Hennig, Christian, MD, Skuljec, Jelena, PhD, Hansen, Gesine, MD

“…Abstract Background Allergic asthma is a chronic lung disease resulting from inappropriate immune responses to environmental antigens. Early tolerance…”
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iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice by Mucci, Adele, Lopez-Rodriguez, Elena, Hetzel, Miriam, Liu, Serena, Suzuki, Takuji, Happle, Christine, Ackermann, Mania, Kempf, Henning, Hillje, Roman, Kunkiel, Jessica, Janosz, Ewa, Brennig, Sebastian, Glage, Silke, Bankstahl, Jens P., Dettmer, Sabine, Rodt, Thomas, Gohring, Gudrun, Trapnell, Bruce, Hansen, Gesine, Trapnell, Cole, Knudsen, Lars, Lachmann, Nico, Moritz, Thomas

“…Induced pluripotent stem cell (iPSC)-derived hematopoietic cells represent a highly attractive source for cell and gene therapy. Given the longevity,…”
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Does refugee status matter? Medical needs of newly arrived asylum seekers and resettlement refugees - a retrospective observational study of diagnoses in a primary care setting by Kleinert, Evelyn, Müller, Frank, Furaijat, Ghefar, Hillermann, Nele, Jablonka, Alexandra, Happle, Christine, Simmenroth, Anne

“…Providing adequate healthcare to newly arrived refugees is considered one of the significant challenges for the German healthcare system. These refugees can be…”
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IRIS: Infection with RespIratory Syncytial Virus in infants-a prospective observational cohort study by Wetzke, Martin, Funken, Dominik, Lange, Mathias, Bejo, Levente, Haid, Sibylle, Monteiro, Joao G Tereno, Schütz, Katharina, Happle, Christine, Schulz, Thomas F, Seidenberg, Jürgen, Pietschmann, Thomas, Hansen, Gesine

“…Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory tract infection in infants. Globally, RSV is responsible for…”
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