Search Results - "Happerfield, Lisa"

Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations by Teo, Ada E.D, Garg, Sumedha, Haris Shaikh, Lalarukh, Zhou, Junhua, Karet Frankl, Fiona E, Gurnell, Mark, Happerfield, Lisa, Marker, Alison, Bienz, Mariann, Azizan, Elena A.B, Brown, Morris J

“…Somatic variants of the β-catenin gene were found in aldosterone-producing adenomas in two pregnant women. These adenomas expressed very high levels of two…”
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Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors by Naguib, Adam, Cooke, James C, Happerfield, Lisa, Kerr, Lucy, Gay, Laura J, Luben, Robert N, Ball, Richard Y, Mitrou, Panagiota N, McTaggart, Alison, Arends, Mark J

“…The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the…”
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Phospho‐STAT5 and phospho‐Akt expression in chronic myeloproliferative neoplasms by Grimwade, Lizz F., Happerfield, Lisa, Tristram, Colin, McIntosh, Gary, Rees, Mark, Bench, Anthony J., Boyd, Elaine M., Hall, Marie, Quinn, Amy, Piggott, Nigel, Scorer, Paul, Scott, Mike A., Erber, Wendy N.

“…Summary The majority of Myeloproliferative Neoplasms (MPNs) are characterised by mutations in genes encoding molecules or receptors involved in cell…”
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DNA replication licensing and human cell proliferation by Stoeber, K, Tlsty, T D, Happerfield, L, Thomas, G A, Romanov, S, Bobrow, L, Williams, E D, Williams, G H

“…The convergence point of growth regulatory pathways that control cell proliferation is the initiation of genome replication, the core of which is the assembly…”
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Improved grading and survival prediction of human astrocytic brain tumors by artificial neural network analysis of gene expression microarray data by Petalidis, Lawrence P, Oulas, Anastasis, Backlund, Magnus, Wayland, Matthew T, Liu, Lu, Plant, Karen, Happerfield, Lisa, Freeman, Tom C, Poirazi, Panayiota, Collins, V Peter

“…Histopathologic grading of astrocytic tumors based on current WHO criteria offers a valuable but simplified representation of oncologic reality and is often…”
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Molecular classification of breast carcinomas using tissue microarrays by Callagy, Grace, Cattaneo, Elena, Daigo, Yataro, Happerfield, Lisa, Bobrow, Lynda G, Pharoah, Paul D P, Caldas, Carlos

“…The histopathologic classification of breast cancer stratifies tumors based on tumor grade, stage, and type. Despite an overall correlation with survival, this…”
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Megaoesophagus in Rassf1a-null mice by Van Der Weyden, Louise, Happerfield, Lisa, Arends, Mark J., Adams, David J.

“…Summary Megaoesophagus, or oesophageal achalasia, is a neuromuscular disorder characterized by an absence of peristalsis and flaccid dilatation of the…”
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A novel CD11c monoclonal antibody effective in formalin-fixed tissue for the diagnosis of hairy cell leukemia by Johrens, Korinna, Happerfield, Lisa C, Brown, John P, Erber, Wendy N, Stein, Harald, Anagnostopoulos, Ioannis

“…The diagnosis of hairy cell leukemia (HCL) and its distinction from other B-cell lymphomas can be difficult in formalin-fixed tissue. This is because the…”
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Abnormal placental CD8+ T‐cell infiltration is a feature of fetal growth restriction and pre‐eclampsia by Lager, Susanne, Sovio, Ulla, Eddershaw, Elizabeth, Linden, Margaretha W., Yazar, Cansu, Cook, Emma, Happerfield, Lisa, Jessop, Flora A., Sebire, Neil J., Charnock‐Jones, D. Stephen, Smith, Gordon C. S.

“…Key points Placental pathological abnormalities are more frequently observed in complicated pregnancies than in healthy pregnancies. Infiltration of CD8+…”
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Microarray, qPCR, and KCNJ5 Sequencing of Aldosterone-Producing Adenomas Reveal Differences in Genotype and Phenotype between Zona Glomerulosa- and Zona Fasciculata-Like Tumors by Azizan, Elena A. B, Lam, Brian Y. H, Newhouse, Stephen J, Zhou, Junhua, Kuc, Rhoda E, Clarke, Jennifer, Happerfield, Lisa, Marker, Alison, Hoffman, Gary J, Brown, Morris J

“…Context: Aldosterone-producing adenomas (APA) are heterogeneous. The recent finding of somatic KCNJ5 mutations suggests a genetic explanation. Objectives: The…”
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Familial Adrenocortical Carcinoma in Association With Lynch Syndrome by Challis, Benjamin G, Kandasamy, Narayanan, Powlson, Andrew S, Koulouri, Olympia, Annamalai, Anand Kumar, Happerfield, Lisa, Marker, Alison J, Arends, Mark J, Nik-Zainal, Serena, Gurnell, Mark

“…Context: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a poor prognosis. Although the majority of childhood ACC arises in the context of…”
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Multilocus Inherited Neoplasia Alleles Syndrome: A Case Series and Review by Whitworth, James, Skytte, Anne-Bine, Sunde, Lone, Lim, Derek H, Arends, Mark J, Happerfield, Lisa, Frayling, Ian M, van Minkelen, Rick, Woodward, Emma R, Tischkowitz, Marc D, Maher, Eamonn R

“…Mendelian causes of inherited cancer susceptibility are mostly rare and characterized by variable expression and incomplete penetrance. Phenotypic variability…”
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802 SOMATIC MUTATIONS OF KCNJ5 ARE COMMON IN ALDOSTERONE-PRODUCING ADENOMAS OF THE ADRENAL, AND DISTINGUISH A PHENOTYPE OF YOUNGER WOMEN WITH ZF-LIKE LARGE ADENOMAS FROM OLDER MEN WITH ZG-LIKE SMALL ADENOMAS by Azizan, Elena, Lam, Brian, Newhouse, Stephen, Zhou, Junhua, Kuc, Rhoda, Clarke, Jennifer, Happerfield, Lisa, Marker, Alison, Hoffman, Gary, Brown, Morris

“…BACKGROUND:Among aldosterone-producing adenomas (APAs), heterogeneity of phenotype is well recognized. Choiʼs finding of KCNJ5 mutations in 8/22 APAs [1],…”
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MLH1 Promoter Methylation, Diet, and Lifestyle Factors in Mismatch Repair Deficient Colorectal Cancer Patients From EPIC-Norfolk by Gay, Laura J, Arends, Mark J, Mitrou, Panagiota N, Bowman, Richard, Ibrahim, Ashraf E, Happerfield, Lisa, Luben, Robert, McTaggart, Alison, Ball, Richard Y, Rodwell, Sheila A

“…There is conflicting evidence for the role diet and lifestyle play in the development of mismatch repair (MMR)-deficient colorectal cancers (CRC). In this…”
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Varicella-zoster contracted in the second trimester of pregnancy by Michie, C A, Acolet, D, Charlton, R, Stevens, J P, Happerfield, L C, Bobrow, L G, Kangro, H, Gau, G, Modi, N

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An immunohistochemical and fluorescence in situ hybridization-based comparison between the Oracle HER2 Bond Immunohistochemical System, Dako HercepTest, and Vysis PathVysion HER2 FISH using both commercially validated and modified ASCO/CAP and United Kingdom HER2 IHC scoring guidelines by O'Grady, Anthony, Allen, David, Happerfield, Lisa, Johnson, Nicola, Provenzano, Elena, Pinder, Sarah E, Tee, Lilian, Gu, Mai, Kay, Elaine W

“…Immunohistochemistry (IHC) is used as the frontline assay to determine HER2 status in invasive breast cancer patients. The aim of the study was to compare the…”
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The localization of the insulin-like growth factor receptor 1 (IGFR-1) in benign and malignant breast tissue by Happerfield, Lisa C., Miles, David W., Barnes, Diana M., Thomsen, Lindy L., Smith, Paul, Hanby, Andrew M.

“…Insulin‐like growth factors (IGFs) play an important role in normal cellular growth and development and have been implicated in the regulation of tumour…”
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Angiogenesis and inflammation in ductal carcinoma in situ of the breast by Lee, Andrew H. S., Happerfield, Lisa C., Bobrow, Lynda G., Millis, Rosemary R.

“…Several recent studies suggest that vascular density may be an independent prognostic indicator in invasive carcinoma of the breast. Increased vascularity has…”
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Ductal carcinoma in situ: assessment of necrosis and nuclear morphology and their association with biological markers by Bobrow, L G, Happerfield, L C, Gregory, W M, Millis, R R

“…One hundred and five cases of pure ductal carcinoma in situ (DCIS) seen in the Guy's Hospital breast unit between 1975 and 1991 were reviewed. The presence and…”
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Angiogenesis and inflammation in ductal carcinomain situ of the breast by Lee, Andrew H. S., Happerfield, Lisa C., Bobrow, Lynda G., Millis, Rosemary R.

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