Design, synthesis and biological evaluation of organotin(IV) complexes of flumequine and cetirizine

Design, synthesis and biological evaluation of organotin(IV) complexes of flumequine and cetirizine

Six new organotin(IV) derivatives [Me3SnL1] (1), [Bu3SnL1] (2), [Ph3SnL1] (3), [Me3SnL2] (4), [Bu3SnL2] (5) and [Ph3SnL2] (6) (where HL1 = = 9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-pyrido[3,2,1-ij]quinoline-2-car­bo­xylic acid (flumequine) and HL2 = 2-[2-[4-[(4-chlorophenyl)phenyl­methyl]- -1-pipe...

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Bibliographic Details
Published in:Journal of the Serbian Chemical Society Vol. 83; no. 4; pp. 425 - 437
Main Authors: Syed Hassan Iftikhar, Gilani, Syeda Rubina, M Babar Taj, Raheel, Ahmad, Din, Imtiaz Ud, Syed Ahmad Tirmizi, Al-Shakban, Mundher, Hapipah Mohd Alie
Format: Journal Article
Language:English
Published: Belgrade Journal of the Serbian Chemical Society 01-01-2018
Serbian Chemical Society
Subjects:
Acetic acid
antimicrobial
antioxidant
Antioxidants
Deoxyribonucleic acid
Derivatives
DNA
DNA binding
Fourier transforms
Fungicides
Infrared spectroscopy
Ligands
Mass spectrometry
NMR
Nuclear magnetic resonance
organotin(IV) complexes
Oxygen atoms
Quinoline
spectroscopy
Thermal analysis
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Summary:Six new organotin(IV) derivatives [Me3SnL1] (1), [Bu3SnL1] (2), [Ph3SnL1] (3), [Me3SnL2] (4), [Bu3SnL2] (5) and [Ph3SnL2] (6) (where HL1 = = 9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-pyrido[3,2,1-ij]quinoline-2-car­bo­xylic acid (flumequine) and HL2 = 2-[2-[4-[(4-chlorophenyl)phenyl­methyl]- -1-piperazinyl]ethoxy] acetic acid (cetirizine)) were synthesized and charac­ter­ized by elemental analysis, FT-IR spectroscopy, multinuclear 1H-, 13C- and 119Sn-NMR, mass spectrometry and thermal analysis techniques. The obtained data reveal trigonal-bipyramidal geometry in case of complexes 1, 2, 4 and 5, and tetrahedral geometry for complexes 3 and 6 around the tin atom, whereas in complexes 3 and 6 the carboxylate ligand act as monodentate ligand through one of its oxygen atoms while it acts as bidentate ligand through two oxygen atoms for complexes 1, 2, 4 and 5. The antibacterial and antifungal efficacies of complexes 1–6 were assessed and the majority of the compounds showed good activities. The present research showed that the trimethyltin(IV) derivat­ives were particularly more effective than tributyltin(IV) and triphenyltin(IV) derivatives against all the bacterial and fungal strains. Antioxidant and DNA binding studies were also performed and promising results were obtained.
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC161203070I