In vitro study of antioxidant, antigylycation, sugar hydrolysis enzyme inhibitory effect and molecular in silico docking study of angularly condensed diquinothiazines

•antioxidant activity of angularly condensed diquinothiazines.•antigylycation effect of angularly condensed diquinothiazines.•sugar hydrolysis enzyme inhibitory effect of angularly condensed diquinothiazines. Angularly condensed diquinothiazines (MY1, MY2, and MY3) a phenothiazine derivative was eva...

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Bibliographic Details
Published in:	Journal of molecular structure Vol. 1296; p. 136856
Main Authors:	Jeleń, Małgorzata, Ying, Pheony Ting Chin, Hao, Yoo Jia, Balachandran, Abbirami, Anamalay, Kirthani, Morak-Młodawska, Beata, Gaurav, Anand, Lavilla, Charlie A., Uy, Mylene M, Billacura, Merell P., Okechukwu, Patrick Nwabueze
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 15-01-2024
Subjects:	Alpha amylase Alpha glucosidase Antiglycation Antioxidant Diazaphenothiazines Diquinothiazines Phenothiazines Alpha glucosidase Antiglycation Alpha amylase Phenothiazines Diquinothiazines Antioxidant Diazaphenothiazines
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Summary:	•antioxidant activity of angularly condensed diquinothiazines.•antigylycation effect of angularly condensed diquinothiazines.•sugar hydrolysis enzyme inhibitory effect of angularly condensed diquinothiazines. Angularly condensed diquinothiazines (MY1, MY2, and MY3) a phenothiazine derivative was evaluated for antioxidant, antiglycation, sugar hydrolysis enzyme inhibitory effect and molecular in silico docking. Antioxidants were evaluated using DPPH, chelating ion, FRAP and lipid peroxidation. Alpha glucosidase and alpha amylase inhibition was used for sugar hydrolysis enzyme inhibitory activity and antiglycation with BSA-Glucose and BSA-MGO. In silco docking was done with AutoDock Vina and ADMET properties with pkCSM software. Angularly condensed diquinothiazines (MY1, MY2, and MY3) showed free radical scavenging, antiglycation and alpha-glucosidase and alpha-amylase inhibition. Insilco docking and pkCSM ADME shows interaction with aldose reductase, glyoxalase 1, receptor AGE, alpha-glucosidase, and alpha-amylase. Antiglycation, alpha-glucosidase, and alpha-amylase inhibition activity of Angularly condensed diquinothiazines maybe through deactivation of aldose reductase enzyme activity, activation of glyoxalase 1 pathway, reduction of dicarbonyl stress and oxidative stress.
ISSN:	0022-2860 1872-8014
DOI:	10.1016/j.molstruc.2023.136856