Search Results - "Hao, Xinxin"
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Temporal dynamics in viral shedding and transmissibility of COVID-19
Published in Nature medicine (01-05-2020)“…We report temporal patterns of viral shedding in 94 patients with laboratory-confirmed COVID-19 and modeled COVID-19 infectiousness profiles from a separate…”
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2
FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism
Published in Nature communications (13-02-2020)“…Alzheimer’s disease (AD) is defined by progressive neurodegeneration, with oligomerization and aggregation of amyloid-β peptides (Aβ) playing a pivotal role in…”
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3
Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020
Published in Euro surveillance : bulletin européen sur les maladies transmissibles (23-01-2020)“…A novel coronavirus (2019-nCoV) causing severe acute respiratory disease emerged recently in Wuhan, China. Information on reported cases strongly indicates…”
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4
Immunomodulation of Antibody Glycosylation through the Placental Transfer
Published in International journal of molecular sciences (01-12-2023)“…Establishing an immune balance between the mother and fetus during gestation is crucial, with the placenta acting as the epicenter of immune tolerance. The…”
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5
Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex
Published in eLife (01-04-2016)“…Huntington disease (HD) is a neurological disorder caused by polyglutamine expansions in mutated Huntingtin (mHtt) proteins, rendering them prone to form…”
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Assessment of the status quo of social responsibility performance of inclusive kindergartens: Evidence from China
Published in PloS one (28-11-2022)“…China is determined to accomplish universal preschool education by asking the kindergartens to participate in social responsibility programs. This study…”
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7
The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates
Published in Cell (22-01-2010)“…The paradigm sirtuin, Sir2p, of budding yeast is required for establishing cellular age asymmetry, which includes the retention of damaged and aggregated…”
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8
Assessment of the status quo of social responsibility performance of inclusive kindergartens: Evidence from China
Published in PloS one (28-11-2022)“…China is determined to accomplish universal preschool education by asking the kindergartens to participate in social responsibility programs. This study…”
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9
The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae
Published in Scientific reports (07-06-2023)“…A hallmark of aging in a variety of organisms is a breakdown of proteostasis and an ensuing accumulation of protein aggregates and inclusions. However, it is…”
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10
Artificial Hsp104-mediated systems for re-localizing protein aggregates
Published in Nature communications (09-05-2023)“…Spatial Protein Quality Control (sPQC) sequesters misfolded proteins into specific, organelle-associated inclusions within the cell to control their toxicity…”
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11
A triple-path global–local feature complementary network for visible-infrared person re-identification
Published in Signal, image and video processing (01-02-2024)“…Cross-modality visible-infrared person re-identification (VI-ReID) aims to match visible and infrared images of pedestrians from different cameras. Most…”
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12
Assessment of Preschool's Inclusive Participation in Social Responsibility Program Under Institutional Pressure: Evidence From China
Published in Frontiers in psychology (09-03-2022)“…China set the goal of expanding early childhood education (ECE) in 2018, by encouraging the development of public interest kindergartens (PIK) to provide…”
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13
The yeast guanine nucleotide exchange factor Sec7 is a bottleneck in spatial protein quality control and detoxifies neurological disease proteins
Published in Scientific reports (28-08-2023)“…ER-to-Golgi trafficking partakes in the sorting of misfolded cytoplasmic proteins to reduce their cytological toxicity. We show here that yeast Sec7, a protein…”
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14
Nuclear Hsp104 safeguards the dormant translation machinery during quiescence
Published in Nature communications (05-01-2024)“…The resilience of cellular proteostasis declines with age, which drives protein aggregation and compromises viability. The nucleus has emerged as a key quality…”
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15
The association of transcription factor Prox1 with the proliferation, migration, and invasion of lung cancer
Published in Open life sciences (19-06-2021)“…The current study investigates the effect of transcription factor Prox1 on the proliferation, migration, and invasion ability of lung cancer. Lung cancer cell…”
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16
Lsm7 phase-separated condensates trigger stress granule formation
Published in Nature communications (28-06-2022)“…Stress granules (SGs) are non-membranous organelles facilitating stress responses and linking the pathology of age-related diseases. In a genome-wide…”
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17
Syntaxin 5 Is Required for the Formation and Clearance of Protein Inclusions during Proteostatic Stress
Published in Cell reports (Cambridge) (20-08-2019)“…Spatial sorting to discrete quality control sites in the cell is a process harnessing the toxicity of aberrant proteins. We show that the yeast t-snare…”
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18
Yeast mismatch repair components are required for stable inheritance of gene silencing
Published in PLoS genetics (29-05-2020)“…Alterations in epigenetic silencing have been associated with ageing and tumour formation. Although substantial efforts have been made towards understanding…”
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Design of Intelligent Management Platform for Industry–Education Cooperation of Vocational Education by Data Mining
Published in Applied sciences (01-07-2022)“…Data are playing an increasingly important role in the development of industry–education cooperation strategies in vocational education and training. The…”
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20
An Hsp90 co-chaperone links protein folding and degradation and is part of a conserved protein quality control
Published in Cell reports (Cambridge) (29-06-2021)“…In this paper, we show that the essential Hsp90 co-chaperone Sgt1 is a member of a general protein quality control network that links folding and degradation…”
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