Search Results - "Hao, Shuanglin"

The Molecular and Pharmacological Mechanisms of HIV-Related Neuropathic Pain by Hao, Shuanglin

“…Infection of the nervous system with the human immunodeficiency virus (HIV-1) can lead to cognitive, motor and sensory disorders. HIV-related sensory…”
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Ryanodine Receptor to Mitochondrial Reactive Oxygen Species Pathway Plays an Important Role in Chronic Human Immunodeficiency Virus gp120MN-Induced Neuropathic Pain in Rats by Godai, Kohei, Takahashi, Keiya, Kashiwagi, Yuta, Liu, Ching-Hang, Yi, Hyun, Liu, Shue, Dong, Chuanhui, Lubarsky, David A., Hao, Shuanglin

“…BACKGROUND:Chronic pain is one of the most common complaints in patients with human immunodeficiency virus (HIV)–associated sensory neuropathy. Ryanodine…”
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The Role of TNFα in the Periaqueductal Gray During Naloxone-Precipitated Morphine Withdrawal in Rats by SHUANGLIN HAO, SHUE LIU, XUEXING ZHENG, WENWEN ZHENG, OUYANG, Handong, MATA, Marina, FINK, David J

“…Tolerance and dependence are common complications of long-term treatment of pain with opioids, which substantially limit the long-term use of these drugs. The…”
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Inhibition of Mitochondrial Fission Protein Reduced Mechanical Allodynia and Suppressed Spinal Mitochondrial Superoxide Induced by Perineural Human Immunodeficiency Virus gp120 in Rats by Kanda, Hirotsugu, Liu, Shue, Iida, Takafumi, Yi, Hyun, Huang, Wan, Levitt, Roy C., Lubarsky, David A., Candiotti, Keith A., Hao, Shuanglin

“…BACKGROUND:Mitochondria play an important role in many cellular and physiologic functions. Mitochondria are dynamic organelles, and their fusion and fission…”
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Reduction of Voltage Gated Sodium Channel Protein in DRG by Vector Mediated miRNA Reduces Pain in Rats with Painful Diabetic Neuropathy by Chattopadhyay, Munmun, Zhou, Zhigang, Hao, Shuanglin, Mata, Marina, Fink, David J

“…Background: Painful neuropathy is a common complication of diabetes. Previous studies have identified significant increases in the amount of voltage gated…”
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Glial TNFα in the Spinal Cord Regulates Neuropathic Pain Induced by HIV gp120 Application in Rats by Zheng, Wenwen, Ouyang, Handong, Zheng, Xuexing, Liu, Shue, Mata, Marina, Fink, David J, Hao, Shuanglin

“…Background: HIV-associated sensory neuropathy (HIV-SN) is one of the most common forms of peripheral neuropathy, affecting about 30% of people with acquired…”
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HSV-Mediated Expression of Interleukin-4 in Dorsal Root Ganglion Neurons Reduces Neuropathic Pain by Hao, Shuanglin, Mata, Marina, Glorioso, Joseph C, Fink, David J

“…Background To examine the role of inflammatory mediators in neuropathic pain, we used a replication-defective genomic herpes simplex virus (HSV)-based vector…”
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IL-10 Mediated by Herpes Simplex Virus Vector Reduces Neuropathic Pain Induced by HIV gp120 Combined with ddC in Rats by Zheng, Wenwen, Huang, Wan, Liu, Shue, Levitt, Roy C, Candiotti, Keith A, Lubarsky, David A, Hao, Shuanglin

“…Background: HIV-associated sensory neuropathy affects over 50% of HIV patients and is a common peripheral nerve complication of HIV infection and highly active…”
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Current Gene Therapy using Viral Vectors for Chronic Pain by Guedon, Jean-Marc G, Wu, Shaogen, Zheng, Xuexing, Churchill, Caroline C, Glorioso, Joseph C, Liu, Ching-Hang, Liu, Shue, Vulchanova, Lucy, Bekker, Alex, Tao, Yuan-Xiang, Kinchington, Paul R, Goins, William F, Fairbanks, Carolyn A, Hao, Shuanglin

“…The complexity of chronic pain and the challenges of pharmacotherapy highlight the importance of development of new approaches to pain management. Gene therapy…”
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Mechanical Allodynia Induced by Nucleoside Reverse Transcriptase Inhibitor Is Suppressed by p55TNFSR Mediated by Herpes Simplex Virus Vector Through the SDF1 alpha/CXCR4 System in Rats by Huang, Wan, Zheng, Wenwen, Ouyang, Handong, Yi, Hyun, Liu, Shue, Zeng, Weian, Levitt, Roy C., Candiotti, Keith A., Lubarsky, David A., Hao, Shuanglin

“…In the human immunodeficiency virus (HIV)-associated sensory neuropathy, neuropathic pain associated with the use of nucleoside reverse transcriptase…”
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Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway by Zhuang, Gerald Z, Keeler, Benjamin, Grant, Jeff, Bianchi, Laura, Fu, Eugene S, Zhang, Yan Ping, Erasso, Diana M, Cui, Jian-Guo, Wiltshire, Tim, Li, Qiongzhen, Hao, Shuanglin, Sarantopoulos, Konstantinos D, Candiotti, Keith, Wishnek, Sarah M, Smith, Shad B, Maixner, William, Diatchenko, Luda, Martin, Eden R, Levitt, Roy C

“…Calcium dysregulation is causally linked with various forms of neuropathology including seizure disorders, multiple sclerosis, Huntington's disease,…”
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Editorial of special issue: Opioid analgesia and opioid use disorder by Hao, Shuanglin

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Peripherally Delivered Glutamic Acid Decarboxylase Gene Therapy for Spinal Cord Injury Pain by Liu, Jun, Wolfe, Darren, Hao, Shuanglin, Huang, Shaohua, Glorioso, Joseph C, Mata, Marina, Fink, David J

“…Neuropathic pain after spinal cord injury (SCI) represents a difficult problem that is commonly refractory to conventional medical management. To determine if…”
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Effects of transgene-mediated endomorphin-2 in inflammatory pain by Hao, Shuanglin, Wolfe, Darren, Glorioso, Joseph C, Mata, Marina, Fink, David J

“…Abstract We examined the analgesic properties of endomorphin-2 expressed in DRG neurons transduced with a non-replicating herpes simplex virus (HSV)-based…”
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Gene transfer of glutamic acid decarboxylase reduces neuropathic pain by Hao, Shuanglin, Mata, Marina, Wolfe, Darren, Glorioso, Joseph C., Fink, David J.

“…We tested whether transfer of the gene coding for glutamic acid decarboxylase to dorsal root ganglion using a herpes simplex virus vector to achieve release of…”
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Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain by Hao, Shuanglin, Hu, Jian, Fink, David J.

“…Chronic morphine exposure induces physical dependence and tolerance. Previous studies have shown that there is a decrease in met-enkephalin levels in states of…”
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An Emerging New Paradigm in Opioid Withdrawal : A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray by Liu, Shue, Ouyang, Handong, Zeng, Weian, Levitt, Roy C., Candiotti, Keith A., Hao, Shuanglin

“…The chronic use of opiates (i.e., narcotics such as the natural derivatives of opium including morphine or codeine) or opioids (i.e., semisynthetic derivatives…”
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Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain by Hao, Shuanglin, Mata, Marina, Goins, William, Glorioso, Joseph C., Fink, David J.

“…We examined the pharmacologic characteristics of herpes simplex virus (HSV) vector-mediated expression of proenkephalin in the dorsal root ganglion in a rodent…”
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HSV-mediated gene transfer of the glial cell-derived neurotrophic factor provides an antiallodynic effect on neuropathic pain by Hao, Shuanglin, Mata, Marina, Wolfe, Darren, Huang, Shaohua, Glorioso, Joseph C, Fink, David J

“…Neuropathic pain is a difficult clinical problem that is often refractory to medical management. Glial-derived neurotrophic factor (GDNF) administered…”
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Chronic Pain and HIV: A Practical Approach by Hao, Shuanglin

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