Search Results - "Hao, Meixi"

Spatiotemporally Controlled T‐Cell Combination Therapy for Solid Tumor by Hao, Meixi, Zhou, Ying, Chen, Sijia, Jin, Yu, Li, Xiuqi, Xue, Lingjing, Shen, Mingxuan, Li, Weishuo, Zhang, Can

“…Due to multidimensional complexity of solid tumor, development of rational T‐cell combinations and corresponding formulations is still challenging. Herein, a…”
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Cytopharmaceuticals: An emerging paradigm for drug delivery by Li, Weishuo, Su, Zhigui, Hao, Meixi, Ju, Caoyun, Zhang, Can

“…Cytopharmaceuticals, in which drugs/nanomedicines are loaded into/onto autologous patient- or allogeneic donor-derived living cells ex vivo, have displayed…”
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Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy by Hao, Meixi, Hou, Siyuan, Li, Weishuo, Li, Kaiming, Xue, Lingjing, Hu, Qifan, Zhu, Lulu, Chen, Yue, Sun, Hongbin, Ju, Caoyun, Zhang, Can

“…Treatment of solid tumors with T cell therapy has yielded limited therapeutic benefits to date. Although T cell therapy in combination with proinflammatory…”
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An EPR-Independent extravasation Strategy: Deformable leukocytes as vehicles for improved solid tumor therapy by Wu, Huayu, Li, Weishuo, Hao, Meixi, Wang, Yujiao, Xue, Lingjing, Ju, Caoyun, Zhang, Can

“…[Display omitted] Effective delivery of therapeutic modality throughout the tumorous nidus plays a crucial role in successful solid tumor treatment. However,…”
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Sensitizing Tumors to Immune Checkpoint Blockage via STING Agonists Delivered by Tumor-Penetrating Neutrophil Cytopharmaceuticals by Hao, Meixi, Zhu, Lulu, Hou, Siyuan, Chen, Sijia, Li, Xiuqi, Li, Kaiming, Zhu, Nianci, Chen, Shanshan, Xue, Lingjing, Ju, Caoyun, Zhang, Can

“…Immune checkpoint inhibitors (ICIs) have displayed potential efficacy in triple-negative breast cancer (TNBC) treatment, while only a minority of patients…”
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Small-Molecule Therapeutics Achieve Multiple Mechanism-Mediated Sensitizations of Colorectal Cancer to Immune Checkpoint Blockade via Neutrophil Micropharmacies by Li, Xiuqi, Liu, Xuwentai, Wang, Meng, Zhang, Xinyi, Zhang, Ziyao, Xue, Lingjing, Xu, Qianqian, Ye, Juanjuan, Hao, Meixi, Zhang, Can

“…Immune checkpoint blockade (ICB) therapy has been approved for colorectal cancer (CRC). However, response rates are variable and often <50%. The low tumor…”
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Modular synthesis of amphiphilic chitosan derivatives based on copper-free click reaction for drug delivery by Tao, Yu, Qu, Ding, Tian, Chunli, Huang, Yingshuang, Xue, Lingjing, Ju, Caoyun, Hao, Meixi, Zhang, Can

“…Schematic representation for modular synthesis of amphiphilic chitosan derivatives based on SPAAC reaction. DCSC and OCSC can self-assemble into micelles to…”
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Design, synthesis and biological evaluation of nonsecosteroidal vitamin D 3 receptor ligands as anti-tumor agents by Wang, Bin, Hao, Meixi, Zhang, Can

“…1α,25-dihydroxyvitamin D (1,25-(OH) D , also known as calcitriol), the active form of vitamin D , is being increasingly recognized for cancer therapy. Our…”
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Real-time detection of T cell activation by visualizing TCR nanoclusters with a cholesterol derived aggregation-induced emission probe by Li, Kaiming, Chen, Yue, Zhu, Nianci, Chen, Sijia, Jia, Meng, Xue, Lingjing, Hao, Meixi, Zhang, Can

“…Successful T-cell based immunotherapy usually depends on the activation of T cells. Most of commonly used methods for assessing T cell activity rely on the…”
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Enhancing Glioblastoma Immunotherapy with Integrated Chimeric Antigen Receptor T Cells through the Re-Education of Tumor-Associated Microglia and Macrophages by Zhu, Nianci, Chen, Sijia, Jin, Yu, Wang, Meng, Fang, Luyao, Xue, Lingjing, Hua, Dexiang, Zhang, Ziyao, Jia, Meng, Hao, Meixi, Zhang, Can

“…Glioblastoma (GBM) is an aggressive brain cancer that is highly resistant to treatment including chimeric antigen receptor (CAR)-T cells. Tumor-associated…”
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Design, synthesis and biological evaluation of nonsecosteroidal vitamin D3 receptor ligands as anti-tumor agents by Wang, Bin, Hao, Meixi, Zhang, Can

“…[Display omitted] 1α,25-dihydroxyvitamin D3 (1,25-(OH)2D3, also known as calcitriol), the active form of vitamin D3, is being increasingly recognized for…”
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Novel Nonsecosteroidal Vitamin D Receptor Modulator Combined with Gemcitabine Enhances Pancreatic Cancer Therapy through Remodeling of the Tumor Microenvironment by Kang, Zisheng, Wang, Cong, Tong, Yu, Li, Yanyi, Gao, Yi, Hou, Siyuan, Hao, Meixi, Han, Xiaolin, Wang, Bin, Wang, Qianqian, Zhang, Can

“…In a pancreatic tumor microenvironment, activated pancreatic stellate cells (PSCs) produce extracellular matrix (ECM) to form a barrier to drug penetration…”
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Further Developments of the Phenyl-Pyrrolyl Pentane Series of Nonsteroidal Vitamin D Receptor Modulators as Anticancer Agents by Hao, Meixi, Hou, Siyuan, Xue, Lingjing, Yuan, Haoliang, Zhu, Lulu, Wang, Cong, Wang, Bin, Tang, Chunming, Zhang, Can

“…The vitamin D3 receptor (VDR), which belongs to the nuclear-receptor superfamily, is a potential molecular target for anticancer-drug discovery. In this study,…”
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Design, synthesis and evaluation of pyrrolo[2,3-d]pyrimidine-phenylamide hybrids as potent Janus kinase 2 inhibitors by Wang, Tingfang, Liu, Xiaofei, Hao, Meixi, Qiao, Jianan, Ju, Caoyun, Xue, Lingjing, Zhang, Can

“…A series of novel pyrrolo[2,3-d]pyrimidine-phenylamide hybrids were designed using the hybridization strategy and synthesized as potential JAK2 inhibitors…”
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Novel nonsecosteroidal VDR ligands with phenyl-pyrrolyl pentane skeleton for cancer therapy by Ge, Zhixin, Hao, Meixi, Xu, Meng, Su, Zhigui, Kang, Zisheng, Xue, Lingjing, Zhang, Can

“…A series of nonsecosteroidal vitamin D3 receptor (VDR) ligands with phenyl-pyrrolyl pentane skeleton were synthesized for cancer therapy. In contrast to…”
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