Search Results - "Hao, Huilin"

O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking by Takeuchi, Hideyuki, Yu, Hongjun, Hao, Huilin, Takeuchi, Megumi, Ito, Atsuko, Li, Huilin, Haltiwanger, Robert S.

“…Glycosylation in the endoplasmic reticulum (ER) is closely associated with protein folding and quality control. We recently described a non-canonical ER…”
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Inhibition of Delta-induced Notch signaling using fucose analogs by Schneider, Michael, Kumar, Vivek, Nordstrøm, Lars Ulrik, Feng, Lei, Takeuchi, Hideyuki, Hao, Huilin, Luca, Vincent C, Garcia, K Christopher, Stanley, Pamela, Wu, Peng, Haltiwanger, Robert S

“…Protein O -fucosyltransferase 1 (Pofut1) regulates Notch activity by adding O -fucose residues to its extracellular domain. Fucose analogs were identified that…”
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Differential Labeling of Glycoproteins with Alkynyl Fucose Analogs by Ma, Chenyu, Takeuchi, Hideyuki, Hao, Huilin, Yonekawa, Chizuko, Nakajima, Kazuki, Nagae, Masamichi, Okajima, Tetsuya, Haltiwanger, Robert S, Kizuka, Yasuhiko

“…Fucosylated glycans critically regulate the physiological functions of proteins and cells. Alterations in levels of fucosylated glycans are associated with…”
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16,17-dihydroxycyclooctatin, a new diterpene from Streptomyces sp. LZ35 by Zhao, G S, Li, S R, Wang, Y Y, Hao, H L, Shen, Y M, Lu, C H

“…Genome sequence analysis of Streptomyces sp. LZ35 has revealed a large number of secondary metabolite pathways, including a complete gene cluster for the…”
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16,17-dihydroxycyclooctatin, a new diterpene from Streptomyces sp.LZ35 by Zhao, Guishi, Li, Shanren, Wang, Yuanyuan, Hao, Huilin, Shen, Yuemao, Lu, Chunhua

“…Genome sequence analysis of Streptomyces sp. LZ35 has revealed a large number of secondary metabolite pathways, including a complete gene cluster for the…”
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Abstract 1667: Profiling of O-fucose proteome using fucose analog by Hao, Huilin, Liu, Zilei, Wu, Peng, Haltiwanger, Robert

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Inhibition of Notch signalling using fucose analogs by Hao, Huilin, Liu, Zilei, Wu, Peng, Haltiwanger, Robert

“…Notch is an evolutionarily conserved cell surface receptor for short range cell‐cell communication and has critical roles in many cell‐fate related events…”
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Expanding the O-Fucosylation Repertoire: Discovery of Novel Protein O-Fucosyltransferases and Profiling the O-Fucose Proteome of POFUT1 and POFUT2 by Hao, Huilin

“…Domain-specific O-fucosylation is an unusual type of glycosylation, where fucose is directly attached to the serine or threonine residues of proteins via an…”
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Nocarbenzoxazoles A–G, Benzoxazoles Produced by Halophilic Nocardiopsis lucentensis DSM 44048 by Sun, Mingwei, Zhang, Xiaomei, Hao, Huilin, Li, Wenjun, Lu, Chunhua

“…Seven new benzoxazole derivatives, nocarbenzoxazoles A–G (1–7), were isolated from the halophilic strain Nocardiopsis lucentensis DSM 44048. Their structures…”
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Inhibition of Notch signalling using fucose analogs by Hao, Huilin, Liu, Zilei, Wu, Peng, Haltiwanger, Robert

“…Abstract only Notch is an evolutionarily conserved cell surface receptor for short range cell‐cell communication. Notch signalling has critical roles in many…”
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Design and synthesis of 2-phenylnaphthalenoids and 2-phenylbenzofuranoids as DNA topoisomerase inhibitors and antitumor agents by Hao, Huilin, Chen, Wang, Zhu, Jing, Lu, Chunhua, Shen, Yuemao

“…Eight 2-phenylnaphthalenoids (2PNs) (3a–h) and twenty four 2-phenylbenzofuranoids (2PBFs) (4a-–4j, 5a–5j, 6a, 6f–6h) were successfully designed, synthesized…”
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p-Terphenyl O-β-glucuronides, DNA topoisomerase inhibitors from Streptomyces sp. LZ35ΔgdmAI by Deng, Jingjing, Lu, Chunhua, Li, Shanren, Hao, Huilin, Li, Zhenyu, Zhu, Jing, Li, Yaoyao, Shen, Yuemao

“…The analysis of genome sequence indicated that Streptomyces sp. LZ35 has the potential of producing many types of secondary metabolites, including p-terphenyls…”
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Analysis of the Healthy Platelet Proteome Identifies a New Form of Domain-Specific O-Fucosylation by Houlahan, Callum B., Kong, Yvonne, Johnston, Bede, Cielesh, Michelle, Chau, The Huong, Fenwick, Jemma, Coleman, Paul R., Hao, Huilin, Haltiwanger, Robert S., Thaysen-Andersen, Morten, Passam, Freda H., Larance, Mark

“…Platelet activation induces the secretion of proteins that promote platelet aggregation and inflammation. However, detailed analysis of the released platelet…”
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Design and synthesis of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-1,2,3,4-tetrahydroisoquinoline-3-carboxamides as novel Hsp90 inhibitors by Liang, Chuanpeng, Hao, Huilin, Wu, Xingkang, Li, Zhenyu, Zhu, Jing, Lu, Chunhua, Shen, Yuemao

“…Heat shock protein 90 (Hsp90) is an attractive chemotherapeutic target for antitumor drug development. Herein, we reported the design and synthesis of two…”
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CS1 is a novel topoisomerase IIα inhibitor with favorable drug resistance profiles by Shen, Yan, Chen, Wang, Zhao, Baobing, Hao, Huilin, Li, Zhenyu, Lu, Chunhua, Shen, Yuemao

“…DNA topoisomerase II (Topo II) is an essential nuclear enzyme and a validated target for anticancer agent screening. CS1, a novel 2-phenylnaphthalene, had…”
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Avertoxins A–D, Prenyl Asteltoxin Derivatives from Aspergillus versicolor Y10, an Endophytic Fungus of Huperzia serrata by Wang, Mingzi, Sun, Mingwei, Hao, Huilin, Lu, Chunhua

“…Aspergillus versicolor Y10 is an endophytic fungus isolated from Huperzia serrata, which showed inhibitory activity against acetylcholinesterase. An…”
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Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors by Li, Zhenyu, Jia, Lejiao, Wang, Jifeng, Wu, Xingkang, Hao, Huilin, Xu, Hongjiao, Wu, Yunfei, Shi, Guowei, Lu, Chunhua, Shen, Yuemao

“…Thirty-three 17-arylmethylamine-substituted derivatives of geldanamycin (GA) were designed, synthesized and evaluated for the anti-proliferation activity on…”
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Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors by Li, Zhenyu, Jia, Lejiao, Wang, Jifeng, Wu, Xingkang, Hao, Huilin, Wu, Yunfei, Xu, Hongjiao, Wang, Zhen, Shi, Guowei, Lu, Chunhua, Shen, Yuemao

“…Heat shock protein 90 (Hsp90) is an attractive target for the development of antitumor agents. Geldanamycin (GA), the first Hsp90 inhibitor, has potent…”
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