Search Results - "Hanzlik, R P"

N-Dealkylation of an N-Cyclopropylamine by Horseradish Peroxidase. Fate of the Cyclopropyl Group by Shaffer, Christopher L, Morton, Martha D, Hanzlik, Robert P

“…Cyclopropylamines inactivate cytochrome P450 enzymes which catalyze their oxidative N-dealkylation. A key intermediate in both processes is postulated to be a…”
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Quinone chemistry and toxicity by Monks, T J, Hanzlik, R P, Cohen, G M, Ross, D, Graham, D G

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Azapeptides as Inhibitors and Active Site Titrants for Cysteine Proteinases by Xing, Ruye, Hanzlik, Robert P.

“…Ester and amide derivatives of α-azaglycine (carbazic acid, H2NNHCOOH), α-azaalanine, and α-azaphenylalanine (i.e., Ac-l-Phe-NHN(R)CO-X, where X = H, CH3, or…”
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Identification of Seven Proteins in the Endoplasmic Reticulum as Targets for Reactive Metabolites of Bromobenzene by Koen, Yakov M, Hanzlik, Robert P

“…The hepatotoxicity of bromobenzene is strongly correlated with the covalent binding of chemically reactive metabolites to cellular proteins, but up to now…”
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Imidazolyl Carboxylic Acids As Mechanistic Probes of Flavocytochrome P-450 BM3 by Noble, M. A, Quaroni, L, Chumanov, George D, Turner, K. L, Chapman, S. K, Hanzlik, R. P, Munro, A. W

“…ω-Imidazolyl carboxylic acids (C10−C12) have been used as probes of the active site and catalytic mechanism of the fatty acid hydroxylase P-450 BM3 from…”
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Enzymatic N-Dealkylation of an N-Cyclopropylamine:  An Unusual Fate for the Cyclopropyl Group by Shaffer, Christopher L, Morton, Martha D, Hanzlik, Robert P

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Synthesis and Evaluation of Peptidyl Michael Acceptors That Inactivate Human Rhinovirus 3C Protease and Inhibit Virus Replication by Kong, Jian-she, Venkatraman, Shankar, Furness, Kelly, Nimkar, Sanjay, Shepherd, Timothy A, Wang, Q. May, Aubé, Jeffrey, Hanzlik, Robert P

“…Human rhinovirus, the chief cause of the common cold, contains a positive-sense strand of RNA which is translated into a large polyprotein in infected cells…”
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Structure-activity relationships for inhibition of papain by peptide Michael acceptors by Liu, Siming, Hanzlik, Robert P

“…Two series of peptidyl Michael acceptors, N-Ac-L-Phe-NHCH2CH = CH-E with different electron withdrawing groups (E = CO2CH3, 1a; SO2CH3, 1b; CO2H, 1c; CN, 1d;…”
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Detection of Aminium Ion Intermediates:  N-Cyclopropyl versus N-Carboxymethyl Groups as Reporters by Totah, Rheem A, Hanzlik, Robert P

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Kinetic deuterium isotope effects on the N-demethylation of tertiary amides by cytochrome P-450 by HALL, L. R, HANZLIK, R. P

“…Liver microsomal cytochrome P-450 readily N-dealkylates N,N-dimethylamides. N-Methyl-N-hydroxymethyl amides were isolated as intermediates and characterized by…”
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Design, synthesis, and evaluation of azapeptides as substrates and inhibitors for human rhinovirus 3C protease by Venkatraman, Shankar, Kong, Jian-she, Nimkar, Sanjay, Wang, Q.May, Aubé, Jeffrey, Hanzlik, Robert P.

“…A series of azapeptides was prepared and assessed as inhibitors of the human rhinovirus 3C protease. Boc-VLFaQ-OPh was a slow-turnover substrate that gave…”
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Electron transfer in P450 mechanisms. Microsomal metabolism of cyclopropylbenzene and p-cyclopropylanisole by Riley, P, Hanzlik, R P

“…1. The metabolism of cyclopropylbenzene (1a) and 4-cyclopropylanisole (1b) was studied using liver microsomal preparations from control, phenobarbital- and…”
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Bromo(monohydroxy)phenyl mercapturic acids. A new class of mercapturic acids from bromobenzene-treated rats by Zheng, J, Hanzlik, R P

“…Alkaline permethylation and GC/MS analysis of urinary mercapturic acids from rats given bromobenzene yielded several quinone-derived bromodimethoxythioanisole…”
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Roles of key active-site residues in flavocytochrome P450 BM3 by Noble, M A, Miles, C S, Chapman, S K, Lysek, D A, MacKay, A C, Reid, G A, Hanzlik, R P, Munro, A W

“…The effects of mutation of key active-site residues (Arg-47, Tyr-51, Phe-42 and Phe-87) in Bacillus megaterium flavocytochrome P450 BM3 were investigated…”
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A Proteomic Analysis of Bromobenzene Reactive Metabolite Targets in Rat Liver Cytosol in Vivo by Koen, Yakov M, Gogichaeva, Natalia V, Alterman, Michail A, Hanzlik, Robert P

“…Metabolic activation and protein covalent binding are early and apparently obligatory events in the cytotoxicity of many simple organic chemicals including…”
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Correlation of metabolism, covalent binding and toxicity for a series of bromobenzene derivatives using rat liver slices in vitro by Fisher, R, Brendel, K, Hanzlik, R P

“…For many acute-acting chemicals, toxic responses observed in vivo correlate strongly with metabolic activation and macromolecular covalent binding (CVB)…”
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Oxidative and non-oxidative metabolism of 4-iodoanisole by rat liver microsomes by Rizk, P N, Hanzlik, R P

“…1. The oxidative metabolism of 4-iodoanisole (1) by liver microsomes from beta-naphthoflavone-treated rats yields 4-iodophenol (2) 2-iodo-5-methoxyphenol (3),…”
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Molecular Mode of Action of a Covalently Inhibiting Peptidomimetic on the Human Calpain Protease Core by Li, Qingshan, Hanzlik, Robert P, Weaver, Robert F, Schönbrunn, Ernst

“…Calpain is a nearly ubiquitous Ca2+-activated proteolytic enzyme whose precise physiological function is unknown. However, aberrant Ca2+ homeostasis in the…”
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Covalent binding of benzoquinone to reduced ribonuclease. Adduct structures and stoichiometry by HANZLIK, R. P, HARRIMAN, S. P, FRAUENHOFF, M. M

“…As a model for the reaction of chemically reactive quinone metabolites with cellular proteins in vivo, the reactions of benzoquinone (BQ; 1-64 mol/mol of…”
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Identification of covalent adducts to protein sulfur nucleophiles by alkaline permethylation by Slaughter, D E, Zheng, J, Harriman, S, Hanzlik, R P

“…We recently reported on the identification of metabolites of the hepatotoxin bromobenzene covalently bound to rat liver protein sulfur nucleophiles (D. E…”
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