Search Results - "Hanyaloglu, Aylin C"

Regulation of GPCRs by Endocytic Membrane Trafficking and Its Potential Implications by HANYALOGLU, Aylin C, VON ZASTROW, Mark

“…The endocytic pathway tightly controls the activity of G protein-coupled receptors (GPCRs). Ligand-induced endocytosis can drive receptors into divergent…”
Get full text

Single Molecule Analysis of Functionally Asymmetric G Protein-coupled Receptor (GPCR) Oligomers Reveals Diverse Spatial and Structural Assemblies by Jonas, Kim C., Fanelli, Francesca, Huhtaniemi, Ilpo T., Hanyaloglu, Aylin C.

“…Formation of G protein-coupled receptors (GPCRs) into dimers and higher order oligomers represents a key mechanism in pleiotropic signaling, yet how individual…”
Get full text

Minireview: Spatial Programming of G Protein-Coupled Receptor Activity: Decoding Signaling in Health and Disease by West, Camilla, Hanyaloglu, Aylin C

“…Probing the multiplicity of hormone signaling via G protein-coupled receptors (GPCRs) has demonstrated the complex signal pathways that underlie the multiple…”
Get full text

Targeting GLP-1 receptor trafficking to improve agonist efficacy by Jones, Ben, Buenaventura, Teresa, Kanda, Nisha, Chabosseau, Pauline, Owen, Bryn M., Scott, Rebecca, Goldin, Robert, Angkathunyakul, Napat, Corrêa Jr, Ivan R., Bosco, Domenico, Johnson, Paul R., Piemonti, Lorenzo, Marchetti, Piero, Shapiro, A. M. James, Cochran, Blake J., Hanyaloglu, Aylin C., Inoue, Asuka, Tan, Tricia, Rutter, Guy A., Tomas, Alejandra, Bloom, Stephen R.

“…Glucagon-like peptide-1 receptor (GLP-1R) activation promotes insulin secretion from pancreatic beta cells, causes weight loss, and is an important…”
Get full text

Intracellular Follicle-Stimulating Hormone Receptor Trafficking and Signaling by Sayers, Niamh, Hanyaloglu, Aylin C

“…Models of G protein-coupled receptor (GPCR) signaling have dramatically altered over the past two decades. Indeed, GPCRs such as the follicle-stimulating…”
Get full text

Integration of GPCR Signaling and Sorting from Very Early Endosomes via Opposing APPL1 Mechanisms by Sposini, Silvia, Jean-Alphonse, Frederic G., Ayoub, Mohammed A., Oqua, Affiong, West, Camilla, Lavery, Stuart, Brosens, Jan J., Reiter, Eric, Hanyaloglu, Aylin C.

“…Endocytic trafficking is a critical mechanism for cells to decode complex signaling pathways, including those activated by G-protein-coupled receptors (GPCRs)…”
Get full text

AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity by Gorvin, Caroline M., Rogers, Angela, Hastoy, Benoit, Tarasov, Andrei I., Frost, Morten, Sposini, Silvia, Inoue, Asuka, Whyte, Michael P., Rorsman, Patrik, Hanyaloglu, Aylin C., Breitwieser, Gerda E., Thakker, Rajesh V.

“…Spatial control of G-protein-coupled receptor (GPCR) signaling, which is used by cells to translate complex information into distinct downstream responses, is…”
Get full text

Nutrigenomic underpinnings of intestinal stem cells in inflammatory bowel disease and colorectal cancer development by Ho, Jennifer, Puoplo, Nicholas, Pokharel, Namrata, Hirdaramani, Aanya, Hanyaloglu, Aylin C, Cheng, Chia-Wei

“…Food-gene interaction has been identified as a leading risk factor for inflammatory bowel disease (IBD) and colorectal cancer (CRC). Accordingly, nutrigenomics…”
Get full text

The GPR120 agonist TUG‐891 promotes metabolic health by stimulating mitochondrial respiration in brown fat by Schilperoort, Maaike, van Dam, Andrea D, Hoeke, Geerte, Shabalina, Irina G, Okolo, Anthony, Hanyaloglu, Aylin C, Dib, Lea H, Mol, Isabel M, Caengprasath, Natarin, Chan, Yi‐Wah, Damak, Sami, Miller, Anne Reifel, Coskun, Tamer, Shimpukade, Bharat, Ulven, Trond, Kooijman, Sander, Rensen, Patrick CN, Christian, Mark

“…Brown adipose tissue (BAT) activation stimulates energy expenditure in human adults, which makes it an attractive target to combat obesity and related…”
Get full text

Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation by Rivero-Müller, Adolfo, Chou, Yen-Yin, Ji, Inhae, Lajic, Svetlana, Hanyaloglu, Aylin C, Jonas, Kim, Rahman, Nafis, Ji, Tae H, Huhtaniemi, Ilpo

“…G protein-coupled receptors (GPCRs) are ubiquitous mediators of signaling of hormones, neurotransmitters, and sensing. The old dogma is that a one ligand/one…”
Get full text

Prostaglandin F2α requires activation of calcium-dependent signalling to trigger inflammation in human myometrium by Riaposova, Lucia, Kim, Sung Hye, Hanyaloglu, Aylin C, Sykes, Lynne, MacIntyre, David A, Bennett, Phillip R, Terzidou, Vasso

“…Preterm birth is one of the major causes of neonatal morbidity and mortality across the world. Both term and preterm labour are preceded by inflammatory…”
Get full text

Pharmacological Programming of Endosomal Signaling Activated by Small Molecule Ligands of the Follicle Stimulating Hormone Receptor by Sposini, Silvia, De Pascali, Francesco, Richardson, Rachel, Sayers, Niamh S, Perrais, David, Yu, Henry N, Palmer, Stephen, Nataraja, Selva, Reiter, Eric, Hanyaloglu, Aylin C

“…Follicle-stimulating hormone receptor (FSHR) is a G protein-coupled receptor (GPCR) with pivotal roles in reproduction. One key mechanism dictating the signal…”
Get full text

Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor by De Pascali, Francesco, Ayoub, Mohammed Akli, Benevelli, Riccardo, Sposini, Silvia, Lehoux, Jordan, Gallay, Nathalie, Raynaud, Pauline, Landomiel, Flavie, Jean-Alphonse, Frédéric, Gauthier, Christophe, Pellissier, Lucie P., Crépieux, Pascale, Poupon, Anne, Inoue, Asuka, Joubert, Nicolas, Viaud-Massuard, Marie-Claude, Casarini, Livio, Simoni, Manuela, Hanyaloglu, Aylin C., Nataraja, Selva G., Yu, Henry N., Palmer, Stephen S., Yvinec, Romain, Reiter, Eric

“…Follicle-stimulating hormone receptor (FSHR) plays a key role in reproduction through the activation of multiple signaling pathways. Low molecular weight (LMW)…”
Get full text

Spatial-temporal regulation of the prostanoid receptor EP2 co-ordinates PGE2-mediated cAMP signaling in decidualizing human endometrium by Brighton, Paul J., Walker, Abigail R., Mann, Oliver, Kong, Chow-Seng, Lucas, Emma S., Vrljicak, Pavle, Brosens, Jan J., Hanyaloglu, Aylin C.

“…Decidualization denotes the differentiation of endometrial stromal cells into specialized decidual cells, essential for embryo implantation and pregnancy. The…”
Get full text

Follicle-Stimulating Hormone Induces Lipid Droplets via Gαi/o and β-Arrestin in an Endometrial Cancer Cell Line by Sayers, Niamh S, Anujan, Priyanka, Yu, Henry N, Palmer, Stephen S, Nautiyal, Jaya, Franks, Stephen, Hanyaloglu, Aylin C

“…Follicle-stimulating hormone (FSH) and its G protein-coupled receptor, FSHR, represents a paradigm for receptor signaling systems that activate multiple and…”
Get full text

Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential[S] by Nikolopoulou, Evanthia, Papacleovoulou, Georgia, Jean-Alphonse, Frederic, Grimaldi, Giulia, Parker, Malcolm G., Hanyaloglu, Aylin C., Christian, Mark

“…Arachidonic acid (AA) is a major PUFA that has been implicated in the regulation of adipogenesis. We examined the effect of a short exposure to AA at different…”
Get full text

The Roles of Prostaglandin EP 1 and 3 Receptors in the Control of Human Myometrial Contractility by Arulkumaran, Shankari, Kandola, Mandeep K, Hoffman, Bryan, Hanyaloglu, Aylin C, Johnson, Mark R, Bennett, Phillip R

“…Context: Prostaglandins are central to the processes of human labor. Prostaglandin E2 (PGE2) synthesized within the uterus mediates cervical ripening and…”
Get full text

Addition of a carboxy-terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice by Toufaily, Chirine, Fortin, Jérôme, Alonso, Carlos Ai, Lapointe, Evelyne, Zhou, Xiang, Santiago-Andres, Yorgui, Lin, Yeu-Farn, Cui, Yiming, Wang, Ying, Devost, Dominic, Roelfsema, Ferdinand, Steyn, Frederik, Hanyaloglu, Aylin C, Hébert, Terence E, Fiordelisio, Tatiana, Boerboom, Derek, Bernard, Daniel J

“…Gonadotropin-releasing hormone (GnRH) is the primary neuropeptide controlling reproduction in vertebrates. GnRH stimulates follicle-stimulating hormone (FSH)…”
Get full text

Membrane Estrogen Receptor (GPER) and Follicle-Stimulating Hormone Receptor (FSHR) Heteromeric Complexes Promote Human Ovarian Follicle Survival by Casarini, Livio, Lazzaretti, Clara, Paradiso, Elia, Limoncella, Silvia, Riccetti, Laura, Sperduti, Samantha, Melli, Beatrice, Marcozzi, Serena, Anzivino, Claudia, Sayers, Niamh S., Czapinski, Jakub, Brigante, Giulia, Potì, Francesco, La Marca, Antonio, De Pascali, Francesco, Reiter, Eric, Falbo, Angela, Daolio, Jessica, Villani, Maria Teresa, Lispi, Monica, Orlando, Giovanna, Klinger, Francesca G., Fanelli, Francesca, Rivero-Müller, Adolfo, Hanyaloglu, Aylin C., Simoni, Manuela

“…Classically, follicle-stimulating hormone receptor (FSHR)-driven cAMP-mediated signaling boosts human ovarian follicle growth and oocyte maturation. However,…”
Get full text

NADPH Oxidase-Derived Reactive Oxygen Species Mediate Decidualization of Human Endometrial Stromal Cells in Response to Cyclic AMP Signaling by Al-Sabbagh, Marwa, Fusi, Luca, Higham, Jenny, Lee, Yun, Lei, Kaiyu, Hanyaloglu, Aylin C, Lam, Eric W.-F, Christian, Mark, Brosens, Jan J

“…NOX-4/p22PHOX-derived reactive oxygen species play an integral role in initiating the endometrial decidual response through regulation of CCAAT/enhancer…”
Get full text