Search Results - "Hantzopoulos, P"

Improved Gene Expression upon Transfer of the Adenosine Deaminase Minigene outside the Transcriptional Unit of a Retroviral Vector by Hantzopoulos, Petros A., Sullenger, Bruce A., Ungers, Grace, Gilboa, Eli

“…This study describes a type of retroviral vector called double-copy (DC) vector that was designed to improve the expression of transduced genes. The unique…”
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Retroviral Gene Transfer Induced Constitutive Expression of Interleukin-2 or Interferon-γ in Irradiated Human Melanoma Cells by Gansbacher, B., Zier, K., Cronin, K., Hantzopoulos, P.A., Bouchard, B., Houghton, A., Gilboa, E., Golde, D.

“…Cytokines are important modulators of host antitumor responses. Two of these cytokines, interleukin-2 (IL-2) and interferon γ (IFN-γ), are produced after…”
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The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins by Hantzopoulos, Petros A, Suri, Chitra, Glass, David J, Goldfarb, Mitchell P, Yancopoulos, George D

“…NGF and the other neurotrophins all bind to the low affinity NGF receptor (LNGFR). Although early studies suggested that the LNGFR was absolutely required for…”
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K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses by Nye, S H, Squinto, S P, Glass, D J, Stitt, T N, Hantzopoulos, P, Macchi, M J, Lindsay, N S, Ip, N Y, Yancopoulos, G D

“…The same receptor tyrosine kinase (RTK) can mediate strikingly different biological responses in a fibroblast as opposed to a neuron. We have compared the…”
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In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: early kinetics of radiolabelled FIAU by Haubner, R, Avril, N, Hantzopoulos, P A, Gansbacher, B, Schwaiger, M

“…Previous studies have shown that the herpes simplex virus type 1 thymidine kinase gene (HSV1-tk), in combination with appropriate radiolabelled substrates…”
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Human α -galactosidase A: Nucleotide Sequence of a cDNA Clone Encoding the Mature Enzyme by Bishop, David F., Calhoun, David H., Bernstein, Harold S., Hantzopoulos, Petros, Quinn, Merrigene, Desnick, Robert J.

“…The complete nucleotide sequence has been determined for a λ gt11 cDNA clone (λ AG18) containing the full-length coding region for the mature lysosomal form of…”
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In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: early kinetics of radiolabelled FIAU by Haubner, Roland, Avril, Norbert, Hantzopoulos, Petros A., Gansbacher, Bernd, Schwaiger, Markus

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Comparison of the expression of a mutant dihydrofolate reductase under control of different internal promoters in retroviral vectors by Li, M, Hantzopoulos, P A, Banerjee, D, Zhao, S C, Schweitzer, B I, Gilboa, E, Bertino, J R

“…To determine the effect of different promoters on the expression of an altered dihydrofolate reductase (DHFR) gene conferring methotrexate (MTX) resistance in…”
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Reduction of breast carcinoma tumor growth and lung colonization by overexpression of the soluble urokinase-type plasminogen activator receptor (CD87) by Krüger, A, Soeltl, R, Lutz, V, Wilhelm, O G, Magdolen, V, Rojo, E E, Hantzopoulos, P A, Graeff, H, Gänsbacher, B, Schmitt, M

“…The serine protease urokinase-type plasminogen activator, uPA, when bound to its specific receptor, uPAR (CD87), plays a significant role in tumor cell…”
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Retroviral Vector-Mediated High-Efficiency Expression of Adenosine Deaminase (ADA) in Hematopoietic Long-Term Cultures of ADA-Deficient Marrow Cells by Bordignon, Claudio, Yu, Sheu-Fung, Smith, Clayton A., Hantzopoulos, Petros, Ungers, Grace E., Keever, Carolyn A., O'Reilly, Richard J., Gilboa, Eli

“…Two recombinant retroviral vectors encoding the cDNA of the human adenosine deaminase (ADA; EC 3.5.4.4) gene and the bacterial neomycin resistance (Neo) gene…”
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Ex vivo gene transfer of brain-derived neurotrophic factor to the intact rat forebrain: neurotrophic effects on cholinergic neurons by Martinez-Serrano, A, Hantzopoulos, P A, Björklund, A

“…Neurotrophic effects of human brain-derived neurotrophic factor (hBDNF) on forebrain cholinergic neurons were addressed after ex vivo gene transfer to the…”
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Different forms of simian virus 40 large tumor antigen varying in their affinities for DNA by Gidoni, D, Scheller, A, Barnet, B, Hantzopoulos, P, Oren, M, Prives, C

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Fabry Disease: Isolation of a cDNA Clone Encoding Human α -galactosidase A by Calhoun, David H., Bishop, David F., Bernstein, Harold S., Quinn, Merrigene, Hantzopoulos, Petros, Desnick, Robert J.

“…Fabry disease is an X-linked inborn error of metabolism resulting from the deficient activity of the lysosomal hydrolase, α -galactosidase A (α -Gal A; α…”
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Expression of the human alpha-galactosidase A in Escherichia coli K-12 by Hantzopoulos, P A, Calhoun, D H

“…We used the prokaryotic expression vector, ptrpL1, for the expression in Escherichia coli K-12 of a cDNA clone specific for the human lysosomal hydrolase,…”
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Cloning and analysis of neurotrophic factor receptors using function-based strategies by Glass, D J, Gies, D R, Stitt, T, Davis, S, Hantzopoulos, P, Ip, N Y, Goldfarb, M, Yancopoulos, G D

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Resistance of Adenoviral DNA Replication to Aphidicolin Is Dependent on the 72-Kilodalton DNA-Binding Protein by Foster, D A, Hantzopoulos, P, Zubay, G

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor by Glass, David J, Nye, Steven H, Hantzopoulos, Petros, Macchi, Mary J, Squinto, Stephen P, Goldfarb, Mitchell, Yancopoulos, George D

“…The neurotrophins (nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], neurotrophin-3 [NT-3], and neurotrophin-4 [NT-4] ) have been defined by…”
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Retroviral gene transfer induced constitutive expression of interleukin- 2 or interferon-gamma in irradiated human melanoma cells by Gansbacher, B, Zier, K, Cronin, K, Hantzopoulos, PA, Bouchard, B, Houghton, A, Gilboa, E, Golde, D

“…Cytokines are important modulators of host antitumor responses. Two of these cytokines, interleukin-2 (IL-2) and interferon gamma (IFN-gamma), are produced…”
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Characterization of glycosylated and catalytically active recombinant human alpha-galactosidase A using a baculovirus vector by Coppola, G, Yan, Y, Hantzopoulos, P, Segura, E, Stroh, J G, Calhoun, D H

“…Fabry disease is an X-linked inborn error of glycolipid metabolism caused by a deficiency of the lysosomal enzyme alpha-galactosidase A (GalA; EC 3.2.1.22). In…”
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Gene therapy--current status and outlook by Hantzopoulos, P A, Gänsbacher, B

“…None of the human gene transfer studies to date has shown definitive proof of clinical efficacy, despite more than 100 clinical protocols involving nearly 600…”
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