Search Results - "Hansson, Oskar"

Biomarkers for neurodegenerative diseases by Hansson, Oskar

“…Biomarkers for neurodegenerative diseases are needed to improve the diagnostic workup in the clinic but also to facilitate the development and monitoring of…”
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Plasma biomarkers of Alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations by Cullen, Nicholas C., Leuzy, Antoine, Janelidze, Shorena, Palmqvist, Sebastian, Svenningsson, Anna L., Stomrud, Erik, Dage, Jeffrey L., Mattsson-Carlgren, Niklas, Hansson, Oskar

“…Plasma biomarkers of amyloid, tau, and neurodegeneration (ATN) need to be characterized in cognitively unimpaired (CU) elderly individuals. We therefore tested…”
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Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer's Disease by Hansson, Oskar, Lehmann, Sylvain, Otto, Markus, Zetterberg, Henrik, Lewczuk, Piotr

“…The cerebrospinal fluid (CSF) biochemical markers (biomarkers) Amyloidβ 42 (Aβ ), total Tau (T-tau) and Tau phosphorylated at threonine 181 (P-tau ) have…”
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Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia by Janelidze, Shorena, Mattsson, Niklas, Palmqvist, Sebastian, Smith, Ruben, Beach, Thomas G., Serrano, Geidy E., Chai, Xiyun, Proctor, Nicholas K., Eichenlaub, Udo, Zetterberg, Henrik, Blennow, Kaj, Reiman, Eric M., Stomrud, Erik, Dage, Jeffrey L., Hansson, Oskar

“…Plasma phosphorylated tau181 (P-tau181) might be increased in Alzheimer’s disease (AD), but its usefulness for differential diagnosis and prognosis is unclear…”
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Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease by Janelidze, Shorena, Stomrud, Erik, Smith, Ruben, Palmqvist, Sebastian, Mattsson, Niklas, Airey, David C., Proctor, Nicholas K., Chai, Xiyun, Shcherbinin, Sergey, Sims, John R., Triana-Baltzer, Gallen, Theunis, Clara, Slemmon, Randy, Mercken, Marc, Kolb, Hartmuth, Dage, Jeffrey L., Hansson, Oskar

“…Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD), reflecting abnormal tau…”
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Increasing the reproducibility of fluid biomarker studies in neurodegenerative studies by Mattsson-Carlgren, Niklas, Palmqvist, Sebastian, Blennow, Kaj, Hansson, Oskar

“…Biomarkers have revolutionized scientific research on neurodegenerative diseases, in particular Alzheimer’s disease, transformed drug trial design, and are…”
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Prediction of future Alzheimer’s disease dementia using plasma phospho-tau combined with other accessible measures by Palmqvist, Sebastian, Tideman, Pontus, Cullen, Nicholas, Zetterberg, Henrik, Blennow, Kaj, Dage, Jeffery L., Stomrud, Erik, Janelidze, Shorena, Mattsson-Carlgren, Niklas, Hansson, Oskar

“…A combination of plasma phospho-tau (P-tau) and other accessible biomarkers might provide accurate prediction about the risk of developing Alzheimer’s disease…”
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Blood-based biomarkers for Alzheimer's disease: towards clinical implementation by Teunissen, Charlotte E, Verberk, Inge M W, Thijssen, Elisabeth H, Vermunt, Lisa, Hansson, Oskar, Zetterberg, Henrik, van der Flier, Wiesje M, Mielke, Michelle M, del Campo, Marta

“…For many years, blood-based biomarkers for Alzheimer's disease seemed unattainable, but recent results have shown that they could become a reality. Convincing…”
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Blood‐based biomarkers for Alzheimer's disease by Leuzy, Antoine, Mattsson‐Carlgren, Niklas, Palmqvist, Sebastian, Janelidze, Shorena, Dage, Jeffrey L, Hansson, Oskar

“…Neurodegenerative disorders such as Alzheimer's disease (AD) represent a mounting public health challenge. As these diseases are difficult to diagnose…”
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Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity by Palmqvist, Sebastian, Schöll, Michael, Strandberg, Olof, Mattsson, Niklas, Stomrud, Erik, Zetterberg, Henrik, Blennow, Kaj, Landau, Susan, Jagust, William, Hansson, Oskar

“…It is not known exactly where amyloid-β (Aβ) fibrils begin to accumulate in individuals with Alzheimer’s disease (AD). Recently, we showed that abnormal levels…”
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Relationship between cortical iron and tau aggregation in Alzheimer's disease by Spotorno, Nicola, Acosta-Cabronero, Julio, Stomrud, Erik, Lampinen, Björn, Strandberg, Olof T, van Westen, Danielle, Hansson, Oskar

“…A growing body of evidence suggests that the dysregulation of neuronal iron may play a critical role in Alzheimer's disease. Recent MRI studies have…”
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Cerebro-spinal fluid biomarker levels: phosphorylated tau (T) and total tau (N) as markers for rate of progression in Alzheimer's disease by Wattmo, Carina, Blennow, Kaj, Hansson, Oskar

“…We investigated the potential associations between cerebro-spinal fluid (CSF) levels of phosphorylated tau (P-tau) and total tau (T-tau) with short-term…”
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Longitudinal plasma p-tau217 is increased in early stages of Alzheimer's disease by Mattsson-Carlgren, Niklas, Janelidze, Shorena, Palmqvist, Sebastian, Cullen, Nicholas, Svenningsson, Anna L, Strandberg, Olof, Mengel, David, Walsh, Dominic M, Stomrud, Erik, Dage, Jeffrey L, Hansson, Oskar

“…Plasma levels of tau phosphorylated at threonine-217 (p-tau217) is a candidate tool to monitor Alzheimer's disease. We studied 150 cognitively unimpaired…”
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Concordance Between Different Amyloid Immunoassays and Visual Amyloid Positron Emission Tomographic Assessment by Janelidze, Shorena, Pannee, Josef, Mikulskis, Alvydas, Chiao, Ping, Zetterberg, Henrik, Blennow, Kaj, Hansson, Oskar

“…Visual assessment of amyloid positron emission tomographic (PET) images has been approved by regulatory authorities for clinical use. Several immunoassays have…”
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CSF biomarkers and clinical progression of Parkinson disease by Hall, Sara, Surova, Yulia, Öhrfelt, Annika, Zetterberg, Henrik, Lindqvist, Daniel, Hansson, Oskar

“…OBJECTIVE:To investigate whether certain CSF biomarkers at baseline can predict future progression of motor symptoms and cognitive decline in patients with…”
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Longitudinal Measurements of Cerebrospinal Fluid Biomarkers in Parkinson's Disease by Hall, Sara, Surova, Yulia, Öhrfelt, Annika, Blennow, Kaj, Zetterberg, Henrik, Hansson, Oskar

“…ABSTRACT Objective The purpose of this study was to investigate whether cerebrospinal fluid (CSF) levels of tau, phosphorylated tau, β‐amyloid42, α‐synuclein,…”
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Diagnostic Performance of RO948 F 18 Tau Positron Emission Tomography in the Differentiation of Alzheimer Disease From Other Neurodegenerative Disorders by Leuzy, Antoine, Smith, Ruben, Ossenkoppele, Rik, Santillo, Alexander, Borroni, Edilio, Klein, Gregory, Ohlsson, Tomas, Jögi, Jonas, Palmqvist, Sebastian, Mattsson-Carlgren, Niklas, Strandberg, Olof, Stomrud, Erik, Hansson, Oskar

“…The diagnostic performance of second-generation tau positron emission tomographic (PET) tracers is not yet known. To examine the novel tau PET tracer RO948 F…”
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Head-to-head comparison of tau positron emission tomography tracers [18F]flortaucipir and [18F]RO948 by Smith, Ruben, Schöll, Michael, Leuzy, Antoine, Jögi, Jonas, Ohlsson, Tomas, Strandberg, Olof, Hansson, Oskar

“…Purpose [ 18 F]flortaucipir binds to paired helical filament tau and accurately identifies tau in Alzheimer’s disease (AD). However, “off-target” binding…”
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The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease by Hansson, Oskar, Edelmayer, Rebecca M., Boxer, Adam L., Carrillo, Maria C., Mielke, Michelle M., Rabinovici, Gil D., Salloway, Stephen, Sperling, Reisa, Zetterberg, Henrik, Teunissen, Charlotte E.

“…Blood‐based markers (BBMs) have recently shown promise to revolutionize the diagnostic and prognostic work‐up of Alzheimer's disease (AD), as well as to…”
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The implications of different approaches to define AT(N) in Alzheimer disease by Mattsson-Carlgren, Niklas, Leuzy, Antoine, Janelidze, Shorena, Palmqvist, Sebastian, Stomrud, Erik, Strandberg, Olof, Smith, Ruben, Hansson, Oskar

“…OBJECTIVETo compare different β-amyloid (Aβ), tau, and neurodegeneration (AT[N]) variants within the Swedish BioFINDER studies. METHODSA total of 490…”
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