Search Results - "Hansson, Magnus J"

Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency by Ehinger, Johannes K., Piel, Sarah, Ford, Rhonan, Karlsson, Michael, Sjövall, Fredrik, Frostner, Eleonor Åsander, Morota, Saori, Taylor, Robert W., Turnbull, Doug M., Cornell, Clive, Moss, Steven J., Metzsch, Carsten, Hansson, Magnus J., Fliri, Hans, Elmér, Eskil

“…Mitochondrial complex I (CI) deficiency is the most prevalent defect in the respiratory chain in paediatric mitochondrial disease. This heterogeneous group of…”
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α1-Microglobulin (A1M) Protects Human Proximal Tubule Epithelial Cells from Heme-Induced Damage In Vitro by Kristiansson, Amanda, Davidsson, Sara, Johansson, Maria E., Piel, Sarah, Elmér, Eskil, Hansson, Magnus J., Åkerström, Bo, Gram, Magnus

“…Oxidative stress is associated with many renal disorders, both acute and chronic, and has also been described to contribute to the disease progression…”
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Mitochondrial dysfunction in blood cells from amyotrophic lateral sclerosis patients by Ehinger, Johannes K., Morota, Saori, Hansson, Magnus J., Paul, Gesine, Elmér, Eskil

“…Mitochondrial dysfunction is implicated in amyotrophic lateral sclerosis, where the progressive degeneration of motor neurons results in muscle atrophy,…”
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Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose by Piel, Sarah, Chamkha, Imen, Dehlin, Adam Kozak, Ehinger, Johannes K, Sjövall, Fredrik, Elmér, Eskil, Hansson, Magnus J

“…Acetaminophen is one of the most common over-the-counter pain medications used worldwide and is considered safe at therapeutic dose. However, intentional and…”
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Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Statin Toxicity by Avram, Vlad F, Chamkha, Imen, Åsander-Frostner, Eleonor, Ehinger, Johannes K, Timar, Romulus Z, Hansson, Magnus J, Muntean, Danina M, Elmér, Eskil

“…Statins are the cornerstone of lipid-lowering therapy. Although generally well tolerated, statin-associated muscle symptoms (SAMS) represent the main reason…”
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Microchannel acoustophoresis does not impact survival or function of microglia, leukocytes or tumor cells by Burguillos, Miguel A, Magnusson, Cecilia, Nordin, Maria, Lenshof, Andreas, Augustsson, Per, Hansson, Magnus J, Elmér, Eskil, Lilja, Hans, Brundin, Patrik, Laurell, Thomas, Deierborg, Tomas

“…The use of acoustic forces to manipulate particles or cells at the microfluidic scale (i.e. acoustophoresis), enables non-contact, label-free separation based…”
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Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning by Piel, Sarah, Janowska, Joanna I., Ward, J. Laurenson, McManus, Meagan J., Jose, Joshua S., Starr, Jonathan, Sheldon, Malkah, Clayman, Carly L., Elmér, Eskil, Hansson, Magnus J., Jang, David H., Karlsson, Michael, Ehinger, Johannes K., Kilbaugh, Todd J.

“…Pesticides account for hundreds of millions of cases of acute poisoning worldwide each year, with organophosphates (OPs) being responsible for the majority of…”
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Mitochondrial respiration in human viable platelets--methodology and influence of gender, age and storage by Sjövall, Fredrik, Ehinger, Johannes K H, Marelsson, Sigurður E, Morota, Saori, Frostner, Eleonor Asander, Uchino, Hiroyuki, Lundgren, Johan, Arnbjörnsson, Einar, Hansson, Magnus J, Fellman, Vineta, Elmér, Eskil

“…Studying whole cell preparations with intact mitochondria and respiratory complexes has a clear benefit compared to isolated or disrupted mitochondria due to…”
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Importance of correct patient positioning in myocardial perfusion SPECT when using a CZT camera by Hindorf, Cecilia, Oddstig, Jenny, Hedeer, Fredrik, Hansson, Magnus J., Jögi, Jonas, Engblom, Henrik

“…Myocardial perfusion single photon emission computed tomography (MPS) is one of the most widely used diagnostic methods in patients with suspected ischemic…”
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Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition by Hansson, Magnus J., Månsson, Roland, Morota, Saori, Uchino, Hiroyuki, Kallur, Thérese, Sumi, Tetsuo, Ishii, Nagao, Shimazu, Motohide, Keep, Marcus F., Jegorov, Alexandr, Elmér, Eskil

“…Mitochondrial uptake of calcium in excitotoxicity is associated with subsequent increase in reactive oxygen species (ROS) generation and delayed cellular…”
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DIVERSE AND TISSUE-SPECIFIC MITOCHONDRIAL RESPIRATORY RESPONSE IN A MOUSE MODEL OF SEPSIS-INDUCED MULTIPLE ORGAN FAILURE by Karlsson, Michael, Hara, Naomi, Morata, Saori, Sjövall, Fredrik, Kilbaugh, Todd, Hansson, Magnus J, Uchino, Hiroyoki, Elmér, Eskil

“…ABSTRACTMitochondrial function is thought to play a role in sepsis-induced multiple organ failure. However, the temporal and organ-specific alterations in…”
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Cytokine and nitric oxide levels in patients with sepsis--temporal evolvement and relation to platelet mitochondrial respiratory function by Sjövall, Fredrik, Morota, Saori, Asander Frostner, Eleonor, Hansson, Magnus J, Elmér, Eskil

“…The levels of nitric oxide (NO) and various cytokines are known to be increased during sepsis. These signaling molecules could potentially act as regulators…”
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Increased Potassium Conductance of Brain Mitochondria Induces Resistance to Permeability Transition by Enhancing Matrix Volume by Hansson, Magnus J., Morota, Saori, Teilum, Maria, Mattiasson, Gustav, Uchino, Hiroyuki, Elmér, Eskil

“…Modulation of K+ conductance of the inner mitochondrial membrane has been proposed to mediate preconditioning in ischemia-reperfusion injury. The mechanism is…”
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Functional and pharmacological characteristics of permeability transition in isolated human heart mitochondria by Morota, Saori, Manolopoulos, Theodor, Eyjolfsson, Atli, Kimblad, Per-Ola, Wierup, Per, Metzsch, Carsten, Blomquist, Sten, Hansson, Magnus J

“…The objective of the present study was to validate the presence and explore the characteristics of mitochondrial permeability transition (mPT) in isolated…”
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Correlation of mitochondrial respiration in platelets, peripheral blood mononuclear cells and muscle fibers by Westerlund, Emil, Marelsson, Sigurður E., Karlsson, Michael, Sjövall, Fredrik, Chamkha, Imen, Åsander Frostner, Eleonor, Lundgren, Johan, Fellman, Vineta, Eklund, Erik A., Steding-Ehrenborg, Katarina, Darin, Niklas, Paul, Gesine, Hansson, Magnus J., Ehinger, Johannes K., Elmér, Eskil

“…There is a growing interest for the possibility of using peripheral blood cells (including platelets) as markers for mitochondrial function in less accessible…”
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Cyclosporine as Therapy for Traumatic Brain Injury by Hansson, Magnus J., Elmér, Eskil

“…Drug development in traumatic brain injury (TBI) has been impeded by the complexity and heterogeneity of the disease pathology, as well as limited…”
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Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis by Simón Serrano, Sonia, Grönberg, Alvar, Longato, Lisa, Rombouts, Krista, Kuo, Joseph, Gregory, Matthew, Moss, Steven, Elmér, Eskil, Mazza, Giuseppe, Gallay, Philippe, Pinzani, Massimo, Hansson, Magnus J, Massoumi, Ramin

“…Hepatic fibrosis can result as a pathological response to nonalcoholic steatohepatitis (NASH). Cirrhosis, the late stage of fibrosis, has been linked to poor…”
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Rationale and design of the Cyclosporine to ImpRove Clinical oUtcome in ST-elevation myocardial infarction patients (the CIRCUS trial) by Mewton, Nathan, MD, PhD, Cung, Thien T., MD, Morel, Olivier, MD, PhD, Cayla, Guillaume, MD, PhD, Bonnefoy-Cudraz, Eric, MD, PhD, Rioufol, Gilles, MD, PhD, Angoulvant, Denis, MD, PhD, Guerin, Patrice, MD, PhD, Elbaz, Meyer, MD, PhD, Delarche, Nicolas, MD, Coste, Pierre, MD, PhD, Vanzetto, Gerald, MD, PhD, Metge, Marc, MD, Aupetit, Jean-François, MD, Jouve, Bernard, MD, Motreff, Pascal, MD, PhD, Tron, Christophe, MD, Labeque, Jean-Noël, MD, Steg, Pierre G., MD, PhD, Cottin, Yves, MD, PhD, Range, Grégoire, MD, Clerc, Jerome, MD, Coussement, Patrick, MD, Prunier, Fabrice, MD, PhD, Moulin, Frederique, MD, Roth, Olivier, MD, Belle, Loic, MD, Dubois, Phillipe, MD, Barragan, Paul, MD, Gilard, Martine, MD, PhD, Piot, Christophe, MD, PhD, Colin, Patrice, MD, Morice, Marie-Claude, MD, Monassier, Jean-Pierre, MD, Ider, Omar, MD, Dubois-Randé, Jean Luc P., MD, PhD, Unterseeh, Thierry, MD, Lebreton, Hervé, MD, PhD, Beard, Thierry, MD, Blanchard, Didier, MD, Grollier, Gilles, MD, Malquarti, Vincent, MD, Staat, Patrick, MD, Sudre, Arnaud, MD, Hansson, Magnus J., MD, Elmer, Eskil, PhD, Boussaha, Inesse, MSc, Jossan, Claire, MSc, Torner, Anna, Claeys, Marc, MD, PhD, Garcia-Dorado, David, MD, PhD, Ovize, Michel, MD, PhD

“…Background Both acute myocardial ischemia and reperfusion contribute to cardiomyocyte death in ST-elevation myocardial infarction (STEMI). The final infarct…”
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Cytokine and nitric oxide levels in patients with sepsis--temporal evolvement and relation to platelet mitochondrial respiratory function by Sjövall, Fredrik, Morota, Saori, Frostner, Eleonor Åsander, Hansson, Magnus J, Elmér, Eskil

“…The levels of nitric oxide (NO) and various cytokines are known to be increased during sepsis. These signaling molecules could potentially act as regulators…”
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Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production by Piel, Sarah, Ehinger, Johannes K., Chamkha, Imen, Frostner, Eleonor Åsander, Sjövall, Fredrik, Elmér, Eskil, Hansson, Magnus J.

“…Background Metformin is the most common pharmacological treatment for type 2 diabetes. It is considered safe but has been associated with the development of…”
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