Search Results - "Hansson, Anita"

Chronic alcohol intake regulates expression of SARS‐CoV2 infection‐relevant genes in an organ‐specific manner by Friske, Marion M., Giannone, Francesco, Senger, Mona, Seitz, Robin, Hansson, Anita C., Spanagel, Rainer

“…Background Chronic alcohol consumption and alcohol use disorder have a tremendous impact on the patient's psychological and physiological health. There is…”
Get full text

No changes in the oxytocin system in alcohol‐dependent female rodents and humans: Towards a sex‐specific psychopharmacology in alcoholism by Hansson, Anita C., Spanagel, Rainer

“…A pronounced decrease of oxytocin and increase of oxytocin receptor binding sites were recently reported in male alcohol dependent rats and male alcohol…”
Get full text

Adverse social experiences in adolescent rats result in persistent sex‐dependent effects on alcohol‐seeking behavior by Surakka, Akseli, Vengeliene, Valentina, Skorodumov, Ivan, Meinhardt, Marcus, Hansson, Anita C., Spanagel, Rainer

“…Background Accumulating clinical evidence suggests that women with prior exposure to adverse childhood experiences are more susceptible to heavy drinking and…”
Get full text

Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill by Lovinger, David M, Holloway, Terrell, Hansson, Anita C, Costa, Rui M, Clouse, Emily, Hilário, Monica R F, Yin, Henry H, Davis, Margaret I, Mulcare, Shweta Prasad

“…The authors use in vivo striatal recordings to study region-specific changes in activity during the different phases of skill learning. The dorsomedial…”
Get full text

Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence by Hirth, Natalie, Meinhardt, Marcus W., Noori, Hamid R., Salgado, Humberto, Torres-Ramirez, Oswaldo, Uhrig, Stefanie, Broccoli, Laura, Vengeliene, Valentina, Roßmanith, Martin, Perreau-Lenz, Stéphanie, Köhr, Georg, Sommer, Wolfgang H., Spanagel, Rainer, Hansson, Anita C.

“…A major hypothesis in addiction research is that alcohol induces neuroadaptations in the mesolimbic dopamine (DA) system and that these neuroadaptations…”
Get full text

Dopamine and opioid systems adaptation in alcoholism revisited: Convergent evidence from positron emission tomography and postmortem studies by Hansson, Anita C., Gründer, Gerhard, Hirth, Natalie, Noori, Hamid R., Spanagel, Rainer, Sommer, Wolfgang H.

“…•A hypodopaminergic model is commonly proposed to underly relapse to alcohol drinking.•Addiction leads to highly dynamic changes in dopamine and opioid…”
Get full text

Reduced oxytocin receptor gene expression and binding sites in different brain regions in schizophrenia: A post-mortem study by Uhrig, Stefanie, Hirth, Natalie, Broccoli, Laura, von Wilmsdorff, Martina, Bauer, Manfred, Sommer, Clemens, Zink, Mathias, Steiner, Johann, Frodl, Thomas, Malchow, Berend, Falkai, Peter, Spanagel, Rainer, Hansson, Anita C, Schmitt, Andrea

“…Abstract Schizophrenia is a severe neuropsychiatric disorder with impairments in social cognition. Several brain regions have been implicated in social…”
Get full text

Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol-Dependent Rats and Humans by Hansson, Anita C, Koopmann, Anne, Uhrig, Stefanie, Bühler, Sina, Domi, Esi, Kiessling, Eva, Ciccocioppo, Roberto, Froemke, Robert C, Grinevich, Valery, Kiefer, Falk, Sommer, Wolfgang H, Vollstädt-Klein, Sabine, Spanagel, Rainer

“…Approved pharmacological treatments for alcohol use disorder are limited in their effectiveness, and new drugs that can easily be translated into the clinic…”
Get full text

Acute and long-term sex-dependent effects of social instability stress on anxiety-like and social behaviours in Wistar rats by Graf, Akseli, Murray, Shealin H., Eltahir, Akif, Patel, Smit, Hansson, Anita C., Spanagel, Rainer, McCormick, Cheryl M.

“…Adolescence is a critical time of social learning in which both the quantity and quality of social interactions shape adult behavior and social function…”
Get full text

Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence by Meinhardt, Marcus W, Hansson, Anita C, Perreau-Lenz, Stephanie, Bauder-Wenz, Christina, Stählin, Oliver, Heilig, Markus, Harper, Clive, Drescher, Karla U, Spanagel, Rainer, Sommer, Wolfgang H

“…A key deficit in alcohol dependence is disrupted prefrontal function leading to excessive alcohol seeking, but the molecular events underlying the emergence of…”
Get full text

Genetic Deletion of Neuronal PPARγ Enhances the Emotional Response to Acute Stress and Exacerbates Anxiety: An Effect Reversed by Rescue of Amygdala PPARγ Function by Domi, Esi, Uhrig, Stefanie, Soverchia, Laura, Spanagel, Rainer, Hansson, Anita C, Barbier, Estelle, Heilig, Markus, Ciccocioppo, Roberto, Ubaldi, Massimo

“…PPARγ is one of the three isoforms of the Peroxisome Proliferator-Activated Receptors (PPARs). PPARγ is activated by thiazolidinediones such as pioglitazone…”
Get full text

Translational Magnetic Resonance Spectroscopy Reveals Excessive Central Glutamate Levels During Alcohol Withdrawal in Humans and Rats by Hermann, Derik, Weber-Fahr, Wolfgang, Sartorius, Alexander, Hoerst, Mareen, Frischknecht, Ulrich, Tunc-Skarka, Nuran, Perreau-Lenz, Stephanie, Hansson, Anita C, Krumm, Bertram, Kiefer, Falk, Spanagel, Rainer, Mann, Karl, Ende, Gabriele, Sommer, Wolfgang H

“…Background In alcoholism, excessive glutamatergic neurotransmission has long been implicated in the acute withdrawal syndrome and as a key signal for…”
Get full text

Isolated during adolescence: long-term impact on social behavior, pain sensitivity, and the oxytocin system in male and female rats by P Graf, Akseli, Hansson, Anita C, Spanagel, Rainer

“…Adolescent social isolation (ASI) has profound long-term effects on behavioral and neural development. Despite this, the specific long-term impact of ASI…”
Get full text

Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)—From trajectories to mechanisms and interventions by Heinz, Andreas, Kiefer, Falk, Smolka, Michael N., Endrass, Tanja, Beste, Christian, Beck, Anne, Liu, Shuyan, Genauck, Alexander, Romund, Lydia, Banaschewski, Tobias, Bermpohl, Felix, Deserno, Lorenz, Dolan, Raymond J., Durstewitz, Daniel, Ebner‐Priemer, Ulrich, Flor, Herta, Hansson, Anita C., Heim, Christine, Hermann, Derik, Kiebel, Stefan, Kirsch, Peter, Kirschbaum, Clemens, Koppe, Georgia, Marxen, Michael, Meyer‐Lindenberg, Andreas, Nagel, Wolfgang E., Noori, Hamid R., Pilhatsch, Maximilian, Priller, Josef, Rietschel, Marcella, Romanczuk‐Seiferth, Nina, Schlagenhauf, Florian, Sommer, Wolfgang H., Stallkamp, Jan, Ströhle, Andreas, Stock, Ann‐Kathrin, Winterer, Georg, Winter, Christine, Walter, Henrik, Witt, Stephanie, Vollstädt‐Klein, Sabine, Rapp, Michael A., Tost, Heike, Spanagel, Rainer

“…One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to…”
Get full text

Choice for Drug or Natural Reward Engages Largely Overlapping Neuronal Ensembles in the Infralimbic Prefrontal Cortex by Pfarr, Simone, Schaaf, Laura, Reinert, Janine K, Paul, Elisabeth, Herrmannsdörfer, Frank, Roßmanith, Martin, Kuner, Thomas, Hansson, Anita C, Spanagel, Rainer, Körber, Christoph, Sommer, Wolfgang H

“…Cue-reward associations form distinct memories that can drive appetitive behaviors and are involved in craving for both drugs and natural rewards. Distinct…”
Get full text

Nicotine increases alcohol self‐administration in male rats via a μ‐opioid mechanism within the mesolimbic pathway by Domi, Esi, Xu, Li, Pätz, Marvin, Nordeman, Anton, Augier, Gaëlle, Holm, Lovisa, Toivainen, Sanne, Augier, Eric, Hansson, Anita C., Heilig, Markus

“…Background and Purpose Alcohol and nicotine use disorders are commonly comorbid. Both alcohol and nicotine can activate opioid systems in reward‐related brain…”
Get full text

Neurocircuitry for modeling drug effects by Noori, Hamid R., Spanagel, Rainer, Hansson, Anita C.

“…The identification and functional understanding of the neurocircuitry that mediates alcohol and drug effects that are relevant for the development of addictive…”
Get full text

Losing Control: Excessive Alcohol Seeking after Selective Inactivation of Cue-Responsive Neurons in the Infralimbic Cortex by Pfarr, Simone, Meinhardt, Marcus W, Klee, Manuela L, Hansson, Anita C, Vengeliene, Valentina, Schönig, Kai, Bartsch, Dusan, Hope, Bruce T, Spanagel, Rainer, Sommer, Wolfgang H

“…Loss of control over drinking is a key deficit in alcoholism causally associated with malfunction of the medial prefrontal cortex (mPFC), but underlying…”
Get full text

Upregulation of Voluntary Alcohol Intake, Behavioral Sensitivity to Stress, and Amygdala Crhr1 Expression Following a History of Dependence by Sommer, Wolfgang H, Rimondini, Roberto, Hansson, Anita C, Hipskind, Philip A, Gehlert, Donald R, Barr, Christina S, Heilig, Markus A

“…Background A history of alcohol dependence recruits increased voluntary alcohol intake and sensitivity to stress. Corticotropin-releasing hormone (CRH) has…”
Get full text

Incubation of cocaine seeking following brief cocaine experience in mice is enhanced by mGluR1 blockade by Halbout, Briac, Bernardi, Rick E, Hansson, Anita C, Spanagel, Rainer

“…The incubation of cocaine craving describes the time-dependent augmentation of cue-induced cocaine seeking during withdrawal from prolonged cocaine…”
Get full text