Search Results - "Hanson, Sonya M"

Heat activation is intrinsic to the pore domain of TRPV1 by Zhang, Feng, Jara-Oseguera, Andres, Chang, Tsg-Hui, Bae, Chanhyung, Hanson, Sonya M., Swartz, Kenton J.

“…The TRPV1 channel is a sensitive detector of pain-producing stimuli, including noxious heat, acid, inflammatory mediators, and vanilloid compounds. Although…”
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Capsaicin Interaction with TRPV1 Channels in a Lipid Bilayer: Molecular Dynamics Simulation by Hanson, Sonya M., Newstead, Simon, Swartz, Kenton J., Sansom, Mark S.P.

“…Transient receptor potential vanilloid subtype 1 (TRPV1) is a heat-sensitive ion channel also involved in pain sensation, and is the receptor for capsaicin,…”
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Do mutations in the murine ataxia gene TRPC3 cause cerebellar ataxia in humans? by Fogel, Brent L., Hanson, Sonya M., Becker, Esther B. E.

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Specificity, synergy, and mechanisms of splice-modifying drugs by Ishigami, Yuma, Wong, Mandy S., Martí-Gómez, Carlos, Ayaz, Andalus, Kooshkbaghi, Mahdi, Hanson, Sonya M., McCandlish, David M., Krainer, Adrian R., Kinney, Justin B.

“…Drugs that target pre-mRNA splicing hold great therapeutic potential, but the quantitative understanding of how these drugs work is limited. Here we introduce…”
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A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation by Ruff, Emily F, Muretta, Joseph M, Thompson, Andrew R, Lake, Eric W, Cyphers, Soreen, Albanese, Steven K, Hanson, Sonya M, Behr, Julie M, Thomas, David D, Chodera, John D, Levinson, Nicholas M

“…Many eukaryotic protein kinases are activated by phosphorylation on a specific conserved residue in the regulatory activation loop, a post-translational…”
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Engineering vanilloid-sensitivity into the rat TRPV2 channel by Zhang, Feng, Hanson, Sonya M, Jara-Oseguera, Andres, Krepkiy, Dmitriy, Bae, Chanhyung, Pearce, Larry V, Blumberg, Peter M, Newstead, Simon, Swartz, Kenton J

“…The TRPV1 channel is a detector of noxious stimuli, including heat, acidosis, vanilloid compounds and lipids. The gating mechanisms of the related TRPV2…”
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Ensembler: Enabling High-Throughput Molecular Simulations at the Superfamily Scale by Parton, Daniel L, Grinaway, Patrick B, Hanson, Sonya M, Beauchamp, Kyle A, Chodera, John D

“…The rapidly expanding body of available genomic and protein structural data provides a rich resource for understanding protein dynamics with biomolecular…”
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Packing of the Extracellular Domain Hydrophobic Core Has Evolved to Facilitate Pentameric Ligand-gated Ion Channel Function by Dellisanti, Cosma D., Hanson, Sonya M., Chen, Lin, Czajkowski, Cynthia

“…Protein function depends on conformational flexibility and folding stability. Loose packing of hydrophobic cores is not infrequent in proteins, as the enhanced…”
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Microtubules and intracellular transport — A microscopic perspective by Sahoo, Abhilash, Farhadifar, Reza, Cossio, Pilar, Hanson, Sonya M.

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Conformational heterogeneity and probability distributions from single-particle cryo-electron microscopy by Tang, Wai Shing, Zhong, Ellen D., Hanson, Sonya M., Thiede, Erik H., Cossio, Pilar

“…Single-particle cryo-electron microscopy (cryo-EM) is a technique that takes projection images of biomolecules frozen at cryogenic temperatures. A major…”
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Protein dynamics underlying allosteric regulation by Astore, Miro A., Pradhan, Akshada S., Thiede, Erik H., Hanson, Sonya M.

“…Allostery is the mechanism by which information and control are propagated in biomolecules. It regulates ligand binding, chemical reactions, and conformational…”
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What Makes a Kinase Promiscuous for Inhibitors? by Hanson, Sonya M, Georghiou, George, Thakur, Manish K, Miller, W Todd, Rest, Joshua S, Chodera, John D, Seeliger, Markus A

“…ATP-competitive kinase inhibitors often bind several kinases due to the high conservation of the ATP binding pocket. Through clustering analysis of a large…”
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Molecular basis of polyglutamine-modulated ELF3 aggregation in Arabidopsis temperature response by Lindsay, Richard J., Wigge, Philip A., Hanson, Sonya M.

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Ensemble Reweighting Using Cryo-EM Particle Images by Tang, Wai Shing, Silva-Sánchez, David, Giraldo-Barreto, Julian, Carpenter, Bob, Hanson, Sonya M., Barnett, Alex H., Thiede, Erik H., Cossio, Pilar

“…Cryo-electron microscopy (cryo-EM) has recently become a leading method for obtaining high-resolution structures of biological macromolecules. However, cryo-EM…”
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Structural ensemble refinement with cryo-EM by Shing Tang, Wai, Silva, David, Giraldo Barreto, Julian, Thiede, Erik H., Hanson, Sonya M., Cossio, Pilar

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Structure-function analysis suggests that the photoreceptor LITE-1 is a light-activated ion channel by Hanson, Sonya M, Scholüke, Jan, Liewald, Jana, Sharma, Rachita, Ruse, Christiane, Engel, Marcial, Schüler, Christina, Klaus, Annabel, Arghittu, Serena, Baumbach, Franziska, Seidenthal, Marius, Dill, Holger, Hummer, Gerhard, Gottschalk, Alexander

“…Sensation of light is essential for all organisms. The eye-less nematode Caenorhabditis elegans detects UV and blue light to evoke escape behavior. The…”
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Reactant Stationary Approximation in Enzyme Kinetics by Hanson, Sonya M, Schnell, Santiago

“…In the application of the quasi-steady-state approximation, it is generally assumed that there is an initial transient during which the substrate concentration…”
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Extracting thermodynamic properties from van 't Hoff plots with emphasis on temperature-sensing ion channels by Bullerjahn, Jakob T., Hanson, Sonya M.

“…Transient receptor potential (TRP) ion channels are among the most well-studied classes of temperature-sensing molecules. Yet, the molecular mechanism and…”
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An Open Library of Human Kinase Domain Constructs for Automated Bacterial Expression by Albanese, Steven K, Parton, Daniel L, Işık, Mehtap, Rodríguez-Laureano, Lucelenie, Hanson, Sonya M, Behr, Julie M, Gradia, Scott, Jeans, Chris, Levinson, Nicholas M, Seeliger, Markus A, Chodera, John D

“…Kinases play a critical role in cellular signaling and are dysregulated in a number of diseases, such as cancer, diabetes, and neurodegeneration. Therapeutics…”
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Modeling error in experimental assays using the bootstrap principle: understanding discrepancies between assays using different dispensing technologies by Hanson, Sonya M., Ekins, Sean, Chodera, John D.

“…All experimental assay data contains error, but the magnitude, type, and primary origin of this error is often not obvious. Here, we describe a simple set of…”
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