Search Results - "Hanson, Phyllis I."

Multivesicular Body Morphogenesis by Hanson, Phyllis I, Cashikar, Anil

“…Multivesicular bodies (MVBs) are unique organelles in the endocytic pathway that contain vesicles in their lumen. Sorting and incorporation of material into…”
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Triggered recruitment of ESCRT machinery promotes endolysosomal repair by Skowyra, Michael L, Schlesinger, Paul H, Naismith, Teresa V, Hanson, Phyllis I

“…Endolysosomes can be damaged by diverse materials. Terminally damaged compartments are degraded by lysophagy, but pathways that repair salvageable organelles…”
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Membrane budding and scission by the ESCRT machinery: it's all in the neck by Hurley, James H, Hanson, Phyllis I

“…Key Points Endosomal sorting complexes required for transport (ESCRTs) are required for the lysosomal degradation of plasma membrane proteins, budding of most…”
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A cell-based assay for CD63-containing extracellular vesicles by Cashikar, Anil G, Hanson, Phyllis I

“…Extracellular vesicles (EVs) are thought to be important in cell-cell communication and have elicited extraordinary interest as potential biomarkers of…”
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Effects of Inhibiting VPS4 Support a General Role for ESCRTs in Extracellular Vesicle Biogenesis by Jackson, Charles E., Scruggs, Benjamin S., Schaffer, Jean E., Hanson, Phyllis I.

“…Extracellular vesicles (EVs) are proposed to play important roles in intercellular communication. Two classes of EVs can be distinguished based on their…”
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Plasma membrane deformation by circular arrays of ESCRT-III protein filaments by Hanson, Phyllis I, Roth, Robyn, Lin, Yuan, Heuser, John E

“…Endosomal sorting complex required for transport III (ESCRT-III) proteins function in multivesicular body biogenesis and viral budding. They are recruited from…”
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Structure and membrane remodeling activity of ESCRT-III helical polymers by McCullough, John, Clippinger, Amy K., Talledge, Nathaniel, Skowyra, Michael L., Saunders, Marissa G., Naismith, Teresa V., Colf, Leremy A., Afonine, Pavel, Arthur, Christopher, Sundquist, Wesley I., Hanson, Phyllis I., Frost, Adam

“…The endosomal sorting complexes required for transport (ESCRT) proteins mediate fundamental membrane remodeling events that require stabilizing negative…”
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Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response by Mittal, Ekansh, Skowyra, Michael L, Uwase, Grace, Tinaztepe, Emir, Mehra, Alka, Köster, Stefan, Hanson, Phyllis I, Philips, Jennifer A

“…Intracellular pathogens have varied strategies to breach the endolysosomal barrier so that they can deliver effectors to the host cytosol, access nutrients,…”
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Redefining the Breast Cancer Exosome Proteome by Tandem Mass Tag Quantitative Proteomics and Multivariate Cluster Analysis by Clark, David J, Fondrie, William E, Liao, Zhongping, Hanson, Phyllis I, Fulton, Amy, Mao, Li, Yang, Austin J

“…Exosomes are microvesicles of endocytic origin constitutively released by multiple cell types into the extracellular environment. With evidence that exosomes…”
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Structure/Function Analysis of Four Core ESCRT‐III Proteins Reveals Common Regulatory Role for Extreme C‐Terminal Domain by Shim, Soomin, Kimpler, Lisa A., Hanson, Phyllis I.

“…Endosomal sorting complex required for transport‐III (ESCRT‐III) is a large complex built from related ESCRT‐III proteins involved in multivesicular body…”
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Structure of cellular ESCRT-III spirals and their relationship to HIV budding by Cashikar, Anil G, Shim, Soomin, Roth, Robyn, Maldazys, Michael R, Heuser, John E, Hanson, Phyllis I

“…The ESCRT machinery along with the AAA+ ATPase Vps4 drive membrane scission for trafficking into multivesicular bodies in the endocytic pathway and for the…”
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Activation of Human VPS4A by ESCRT-III Proteins Reveals Ability of Substrates to Relieve Enzyme Autoinhibition by Merrill, Samuel A., Hanson, Phyllis I.

“…VPS4 proteins are AAA+ ATPases required to form multivesicular bodies, release viral particles, and complete cytokinesis. They act by disassembling ESCRT-III…”
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Impaired Protein Aggregate Handling and Clearance Underlie the Pathogenesis of p97/VCP-associated Disease by Ju, Jeong-Sun, Miller, Sara E., Hanson, Phyllis I., Weihl, Conrad C.

“…Mutations in p97/VCP cause the multisystem disease inclusion body myopathy, Paget disease of the bone and frontotemporal dementia (IBMPFD). p97/VCP is a member…”
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Access of torsinA to the inner nuclear membrane is activity dependent and regulated in the endoplasmic reticulum by Goodchild, Rose E, Buchwalter, Abigail L, Naismith, Teresa V, Holbrook, Kristen, Billion, Karolien, Dauer, William T, Liang, Chun-Chi, Dear, Mary Lynn, Hanson, Phyllis I

“…TorsinA (also known as torsin-1A) is a membrane-embedded AAA+ ATPase that has an important role in the nuclear envelope lumen. However, most torsinA is…”
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Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation by Weihl, Conrad C., Dalal, Seema, Pestronk, Alan, Hanson, Phyllis I.

“…Mutations in the AAA+ protein (ATPase associated with a variety of cellular activities) p97/VCP (valosin-containing protein) cause a dominantly inherited…”
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Ubiquitin Depletion and Dominant-Negative VPS4 Inhibit Rhabdovirus Budding without Affecting Alphavirus Budding by TAYLOR, Gwen M, HANSON, Phyllis I, KIELIAN, Margaret

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Transgenic expression of inclusion body myopathy associated mutant p97/VCP causes weakness and ubiquitinated protein inclusions in mice by Weihl, Conrad C., Miller, Sara E., Hanson, Phyllis I., Pestronk, Alan

“…Mutations in p97/VCP cause the autosomal-dominant, inherited syndrome inclusion body myopathy (IBM) associated with Paget's disease of the bone and…”
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Static retention of the lumenal monotopic membrane protein torsinA in the endoplasmic reticulum by Vander Heyden, Abigail B, Naismith, Teresa V, Snapp, Erik L, Hanson, Phyllis I

“…TorsinA is a membrane‐associated enzyme in the endoplasmic reticulum (ER) lumen that is mutated in DYT1 dystonia. How it remains in the ER has been unclear. We…”
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TorsinA in the Nuclear Envelope by Naismith, Teresa V., Heuser, John E., Breakefield, Xandra O., Hanson, Phyllis I., De Camilli, Pietro V.

“…Early-onset torsion dystonia, a CNS-based movement disorder, is usually associated with a single amino acid deletion (ΔE302/303) in the protein torsinA…”
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An essential and NSF independent role for α-SNAP in store-operated calcium entry by Miao, Yong, Miner, Cathrine, Zhang, Lei, Hanson, Phyllis I, Dani, Adish, Vig, Monika

“…Store-operated calcium entry (SOCE) by calcium release activated calcium (CRAC) channels constitutes a primary route of calcium entry in most cells. Orai1…”
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