Search Results - "Hanson, Michael A."

Crystal Structure of the Human Cannabinoid Receptor CB1 by Hua, Tian, Vemuri, Kiran, Pu, Mengchen, Qu, Lu, Han, Gye Won, Wu, Yiran, Zhao, Suwen, Shui, Wenqing, Li, Shanshan, Korde, Anisha, Laprairie, Robert B., Stahl, Edward L., Ho, Jo-Hao, Zvonok, Nikolai, Zhou, Han, Kufareva, Irina, Wu, Beili, Zhao, Qiang, Hanson, Michael A., Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie

“…Cannabinoid receptor 1 (CB1) is the principal target of Δ9-tetrahydrocannabinol (THC), a psychoactive chemical from Cannabis sativa with a wide range of…”
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Crystal structures of agonist-bound human cannabinoid receptor CB1 by Hua, Tian, Vemuri, Kiran, Nikas, Spyros P., Laprairie, Robert B., Wu, Yiran, Qu, Lu, Pu, Mengchen, Korde, Anisha, Jiang, Shan, Ho, Jo-Hao, Han, Gye Won, Ding, Kang, Li, Xuanxuan, Liu, Haiguang, Hanson, Michael A., Zhao, Suwen, Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie

“…Crystal structures of the human cannabinoid receptor 1 (CB 1 ) bound to the agonists AM11542 and AM841 reveal notable structural rearrangements upon receptor…”
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Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1 by Chrencik, Jill E., Roth, Christopher B., Terakado, Masahiko, Kurata, Haruto, Omi, Rie, Kihara, Yasuyuki, Warshaviak, Dora, Nakade, Shinji, Asmar-Rovira, Guillermo, Mileni, Mauro, Mizuno, Hirotaka, Griffith, Mark T., Rodgers, Caroline, Han, Gye Won, Velasquez, Jeffrey, Chun, Jerold, Stevens, Raymond C., Hanson, Michael A.

“…Lipid biology continues to emerge as an area of significant therapeutic interest, particularly as the result of an enhanced understanding of the wealth of…”
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Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors by Chun, Eugene, Thompson, Aaron A., Liu, Wei, Roth, Christopher B., Griffith, Mark T., Katritch, Vsevolod, Kunken, Joshua, Xu, Fei, Cherezov, Vadim, Hanson, Michael A., Stevens, Raymond C.

“…Structural studies of human G protein-coupled receptors (GPCRs) have recently been accelerated through the use of a fusion partner that was inserted into the…”
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An online resource for GPCR structure determination and analysis by Munk, Christian, Mutt, Eshita, Isberg, Vignir, Nikolajsen, Louise F., Bibbe, Janne M., Flock, Tilman, Hanson, Michael A., Stevens, Raymond C., Deupi, Xavier, Gloriam, David E.

“…G-protein-coupled receptors (GPCRs) transduce physiological and sensory stimuli into appropriate cellular responses and mediate the actions of one-third of…”
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Full-length human GLP-1 receptor structure without orthosteric ligands by Wu, Fan, Yang, Linlin, Hang, Kaini, Laursen, Mette, Wu, Lijie, Han, Gye Won, Ren, Qiansheng, Roed, Nikolaj Kulahin, Lin, Guangyao, Hanson, Michael A., Jiang, Hualiang, Wang, Ming-Wei, Reedtz-Runge, Steffen, Song, Gaojie, Stevens, Raymond C.

“…Glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor that plays an important role in glucose homeostasis and treatment of type 2…”
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Crystal Structure of a Lipid G Protein—Coupled Receptor by Hanson, Michael A., Roth, Christopher B., Jo, Euijung, Griffith, Mark T., Scott, Fiona L., Reinhart, Greg, Desale, Hans, Clemons, Bryan, Cahalan, Stuart M., Schuerer, Stephan C., Sanna, M. Germana, Han, Gye Won, Kuhn, Peter, Rosen, Hugh, Stevens, Raymond C.

“…The lyso-phospholipid sphingosine 1-phosphate modulates lymphocyte trafficking, endothelial development and integrity, heart rate, and vascular tone and…”
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Discovery of New GPCR Biology: One Receptor Structure at a Time by Hanson, Michael A., Stevens, Raymond C.

“…G-protein-coupled receptors (GPCRs) are the largest family of proteins in the human genome. Within the last year, we have witnessed a relative explosion in the…”
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Structure of the full-length glucagon class B G-protein-coupled receptor by Zhang, Haonan, Qiao, Anna, Yang, Dehua, Yang, Linlin, Dai, Antao, de Graaf, Chris, Reedtz-Runge, Steffen, Dharmarajan, Venkatasubramanian, Zhang, Hui, Han, Gye Won, Grant, Thomas D., Sierra, Raymond G., Weierstall, Uwe, Nelson, Garrett, Liu, Wei, Wu, Yanhong, Ma, Limin, Cai, Xiaoqing, Lin, Guangyao, Wu, Xiaoai, Geng, Zhi, Dong, Yuhui, Song, Gaojie, Griffin, Patrick R., Lau, Jesper, Cherezov, Vadim, Yang, Huaiyu, Hanson, Michael A., Stevens, Raymond C., Zhao, Qiang, Jiang, Hualiang, Wang, Ming-Wei, Wu, Beili

“…The human glucagon receptor, GCGR, belongs to the class B G-protein-coupled receptor family and plays a key role in glucose homeostasis and the pathophysiology…”
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High-Resolution Crystal Structure of an Engineered Human β₂-Adrenergic G Protein-Coupled Receptor by Cherezov, Vadim, Rosenbaum, Daniel M, Hanson, Michael A, Rasmussen, Søren G.F, Thian, Foon Sun, Kobilka, Tong Sun, Choi, Hee-Jung, Kuhn, Peter, Weis, William I, Kobilka, Brian K, Stevens, Raymond C

“…Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors constitute the largest family of eukaryotic signal transduction proteins that…”
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Structural Basis for Apelin Control of the Human Apelin Receptor by Ma, Yingli, Yue, Yang, Ma, Yanbin, Zhang, Qing, Zhou, Qingtong, Song, Yunpeng, Shen, Yuqing, Li, Xun, Ma, Xiaochuan, Li, Chao, Hanson, Michael A., Han, Gye Won, Sickmier, E. Allen, Swaminath, Gayathri, Zhao, Suwen, Stevens, Raymond C., Hu, Liaoyuan A., Zhong, Wenge, Zhang, Mingqiang, Xu, Fei

“…Apelin receptor (APJR) is a key regulator of human cardiovascular function and is activated by two different endogenous peptide ligands, apelin and Elabela,…”
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Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand by Zhang, Xianjun, Zhao, Fei, Wu, Yiran, Yang, Jun, Han, Gye Won, Zhao, Suwen, Ishchenko, Andrii, Ye, Lintao, Lin, Xi, Ding, Kang, Dharmarajan, Venkatasubramanian, Griffin, Patrick R., Gati, Cornelius, Nelson, Garrett, Hunter, Mark S., Hanson, Michael A., Cherezov, Vadim, Stevens, Raymond C., Tan, Wenfu, Tao, Houchao, Xu, Fei

“…The Smoothened receptor (SMO) belongs to the Class Frizzled of the G protein-coupled receptor (GPCR) superfamily, constituting a key component of the Hedgehog…”
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Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases by Xu, Fei, Liu, Wei, Hanson, Michael A, Stevens, Raymond C, Cherezov, Vadim

“…Crystallization in lipidic mesophases (in meso) has been successfully used to obtain a number of high-resolution membrane protein structures including…”
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Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor by Audet, Martin, White, Kate L., Breton, Billy, Zarzycka, Barbara, Han, Gye Won, Lu, Yan, Gati, Cornelius, Batyuk, Alexander, Popov, Petr, Velasquez, Jeffrey, Manahan, David, Hu, Hao, Weierstall, Uwe, Liu, Wei, Shui, Wenqing, Katritch, Vsevolod, Cherezov, Vadim, Hanson, Michael A., Stevens, Raymond C.

“…Misoprostol is a life-saving drug in many developing countries for women at risk of post-partum hemorrhaging owing to its affordability, stability, ease of…”
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Crystal structures of agonist-bound human cannabinoid receptor CB 1 by Hua, Tian, Vemuri, Kiran, Nikas, Spyros P, Laprairie, Robert B, Wu, Yiran, Qu, Lu, Pu, Mengchen, Korde, Anisha, Jiang, Shan, Ho, Jo-Hao, Han, Gye Won, Ding, Kang, Li, Xuanxuan, Liu, Haiguang, Hanson, Michael A, Zhao, Suwen, Bohn, Laura M, Makriyannis, Alexandros, Stevens, Raymond C, Liu, Zhi-Jie

“…The cannabinoid receptor 1 (CB ) is the principal target of the psychoactive constituent of marijuana, the partial agonist Δ -tetrahydrocannabinol (Δ -THC)…”
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Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators by Song, Gaojie, Yang, Dehua, Wang, Yuxia, de Graaf, Chris, Zhou, Qingtong, Jiang, Shanshan, Liu, Kaiwen, Cai, Xiaoqing, Dai, Antao, Lin, Guangyao, Liu, Dongsheng, Wu, Fan, Wu, Yiran, Zhao, Suwen, Ye, Li, Han, Gye Won, Lau, Jesper, Wu, Beili, Hanson, Michael A., Liu, Zhi-Jie, Wang, Ming-Wei, Stevens, Raymond C.

“…Crystal structures of the human GLP-1 receptor in complex with two negative allosteric modulators reveal a common binding pocket, and, together with…”
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Structure of the glucagon receptor in complex with a glucagon analogue by Zhang, Haonan, Qiao, Anna, Yang, Linlin, Van Eps, Ned, Frederiksen, Klaus S., Yang, Dehua, Dai, Antao, Cai, Xiaoqing, Zhang, Hui, Yi, Cuiying, Cao, Can, He, Lingli, Yang, Huaiyu, Lau, Jesper, Ernst, Oliver P., Hanson, Michael A., Stevens, Raymond C., Wang, Ming-Wei, Reedtz-Runge, Steffen, Jiang, Hualiang, Zhao, Qiang, Wu, Beili

“…The crystal structure of the full-length glucagon receptor in complex with a glucagon analogue NNC1702 reveals how the peptide ligand interacts with its target…”
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Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist by Chien, Ellen Y.T, Liu, Wei, Zhao, Qiang, Katritch, Vsevolod, Won Han, Gye, Hanson, Michael A, Shi, Lei, Newman, Amy Hauck, Javitch, Jonathan A, Cherezov, Vadim, Stevens, Raymond C

“…Dopamine modulates movement, cognition, and emotion through activation of dopamine G protein-coupled receptors in the brain. The crystal structure of the human…”
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2.6 Angstrom Crystal Structure of a Human A₂A Adenosine Receptor Bound to an Antagonist by Jaakola, Veli-Pekka, Griffith, Mark T, Hanson, Michael A, Cherezov, Vadim, Chien, Ellen Y.T, Lane, J. Robert, IJzerman, Adriaan P, Stevens, Raymond C

“…The adenosine class of heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) mediates the important role of extracellular…”
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5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology by Peng, Yao, McCorvy, John D., Harpsøe, Kasper, Lansu, Katherine, Yuan, Shuguang, Popov, Petr, Qu, Lu, Pu, Mengchen, Che, Tao, Nikolajsen, Louise F., Huang, Xi-Ping, Wu, Yiran, Shen, Ling, Bjørn-Yoshimoto, Walden E., Ding, Kang, Wacker, Daniel, Han, Gye Won, Cheng, Jianjun, Katritch, Vsevolod, Jensen, Anders A., Hanson, Michael A., Zhao, Suwen, Gloriam, David E., Roth, Bryan L., Stevens, Raymond C., Liu, Zhi-Jie

“…Drugs frequently require interactions with multiple targets—via a process known as polypharmacology—to achieve their therapeutic actions. Currently, drugs…”
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