Search Results - "Hanson, Leah R"

Oxytocin enhances observational fear in mice by Pisansky, Marc T., Hanson, Leah R., Gottesman, Irving I., Gewirtz, Jonathan C.

“…Empathy is fundamental to human relations, but its neural substrates remain largely unknown. Here we characterize the involvement of oxytocin in the capacity…”
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Intranasal delivery to the central nervous system: mechanisms and experimental considerations by Dhuria, Shyeilla V, Hanson, Leah R, Frey, 2nd, William H

“…The blood-brain barrier (BBB) limits the distribution of systemically administered therapeutics to the central nervous system (CNS), posing a significant…”
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Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease by Hanson, Leah R, Frey, 2nd, William H

“…Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal…”
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Mindfulness-based stress reduction for family caregivers: a randomized controlled trial by Whitebird, Robin R, Kreitzer, MaryJo, Crain, A Lauren, Lewis, Beth A, Hanson, Leah R, Enstad, Chris J

“…Caring for a family member with dementia is associated with chronic stress, which can have significant deleterious effects on caregivers. The purpose of the…”
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Trigeminal Pathways Deliver a Low Molecular Weight Drug from the Nose to the Brain and Orofacial Structures by Johnson, Neil J, Hanson, Leah R, Frey, William H

“…Intranasal delivery has been shown to noninvasively deliver drugs from the nose to the brain in minutes along the olfactory and trigeminal nerve pathways,…”
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Mechanisms of Intranasal Deferoxamine in Neurodegenerative and Neurovascular Disease by Kosyakovsky, Jacob, Fine, Jared M, Frey, 2nd, William H, Hanson, Leah R

“…Identifying disease-modifying therapies for neurological diseases remains one of the greatest gaps in modern medicine. Herein, we present the rationale for…”
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Intranasal delivery of low-dose insulin ameliorates motor dysfunction and dopaminergic cell death in a 6-OHDA rat model of Parkinson’s Disease by Fine, Jared M., Stroebel, Benjamin M., Faltesek, Katherine A., Terai, Kaoru, Haase, Lucas, Knutzen, Kristin E., Kosyakovsky, Jacob, Bowe, Tate J., Fuller, Austin K., Frey, William H., Hanson, Leah R.

“…•We determined whether intranasal insulin would mitigate the behavioral and neuropathological effects of 6-OHDA in a rat model of PD.•Insulin decreased the…”
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Nasal oxytocin for the treatment of psychiatric disorders and pain: achieving meaningful brain concentrations by Yeomans, David C., Hanson, Leah R., Carson, Dean S., Tunstall, Brendan J., Lee, Mary R., Tzabazis, Alexander Z., Jacobs, Daniel, Frey, William H.

“…There is evidence of the therapeutic potential of intranasal oxytocin for the treatment of pain and various psychiatric disorders, however, there is scant…”
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Intranasal Adeno-Associated Virus Mediated Gene Delivery and Expression of Human Iduronidase in the Central Nervous System: A Noninvasive and Effective Approach for Prevention of Neurologic Disease in Mucopolysaccharidosis Type I by Belur, Lalitha R, Temme, Alexa, Podetz-Pedersen, Kelly M, Riedl, Maureen, Vulchanova, Lucy, Robinson, Nicholas, Hanson, Leah R, Kozarsky, Karen F, Orchard, Paul J, Frey, 2nd, William H, Low, Walter C, McIvor, R Scott

“…Mucopolysaccharidosis type I (MPS I) is a progressive, multi-systemic, inherited metabolic disease caused by deficiency of α-L-iduronidase (IDUA). Current…”
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Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke by Hanson, Leah R, Roeytenberg, Annina, Martinez, Paula M, Coppes, Valerie G, Sweet, Donald C, Rao, Reshma J, Marti, Dianne L, Hoekman, John D, Matthews, Rachel B, Frey, 2nd, William H, Panter, S Scott

“…Deferoxamine (DFO) is a high-affinity iron chelator approved by the Food and Drug Administration for treating iron overload. Preclinical research suggests that…”
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Intranasal delivery of insulin via the olfactory nerve pathway by Renner, Dan B., Svitak, Aleta L., Gallus, Nathan J., Ericson, Marna E., Frey II, William H., Hanson, Leah R.

“…Objectives  Intranasal delivery has been shown to target peptide therapeutics to the central nervous system (CNS) of animal models and induce specific…”
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Stroke Characteristics in a Cohort of Hmong American Patients by Hussein, Haitham M, Kashyap, Bhavani, O'Keefe, Lauren, Droegemueller, Carol, Othman, Sally I, Yang, Mai Kau, Hanson, Leah R

“…Background Prior studies have indicated high rates of vascular risk factors, but little is known about stroke in Hmong. Methods and Results The institutional…”
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Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system by Dhuria, Shyeilla V, Hanson, Leah R, Frey, 2nd, William H

“…The blood-brain barrier (BBB) limits the distribution of systemically administered therapeutics to the central nervous system (CNS). Intranasal delivery is a…”
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Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation by Fine, Jared M., Renner, Daniel B., Forsberg, Anna C., Cameron, Rachel A., Galick, Benjamin T., Le, Clint, Conway, Patrick M., Stroebel, Benjamin M., Frey, William H., Hanson, Leah R.

“…•Intranasal DFO reduces working and reference memory loss in an amyloid mouse model.•Intranasal DFO modifies several targets along multiple pathways in…”
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Losartan Improves Memory, Neurogenesis and Cell Motility in Transgenic Alzheimer's Mice by Drews, Henning Johannes, Klein, Roman, Lourhmati, Ali, Buadze, Marine, Schaeffeler, Elke, Lang, Thomas, Seferyan, Torgom, Hanson, Leah R, Frey Ii, William H, de Vries, Tom C G M, Thijssen-van Loosdregt, Inge A E W, Gleiter, Christoph H, Schwab, Matthias, Danielyan, Lusine

“…Angiotensin receptor blockers (ARBs) have demonstrated multiple neuroprotective benefits in Alzheimer's disease (AD) models. However, their beneficial effects…”
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Brain Glucose Hypometabolism and Iron Accumulation in Different Brain Regions in Alzheimer's and Parkinson's Diseases by Rao, Indira Y, Hanson, Leah R, Johnson, Julia C, Rosenbloom, Michael H, Frey, 2nd, William H

“…The aim of this study was to examine the relationship between the presence of glucose hypometabolism (GHM) and brain iron accumulation (BIA), two potential…”
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Double-Blind Placebo-Controlled Pilot Investigation of the Safety of a Single Dose of Rapid-Acting Intranasal Insulin in Down Syndrome by Rosenbloom, Michael, Barclay, Terry, Johnsen, Justin, Erickson, Lauren, Svitak, Aleta, Pyle, Maria, Frey, William, Hanson, Leah R.

“…Background Individuals with Down syndrome are likely to develop clinical and neuropathological brain changes resembling Alzheimer’s disease dementia by the…”
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Intranasal delivery of siRNA to the olfactory bulbs of mice via the olfactory nerve pathway by Renner, Dan B., Frey, William H., Hanson, Leah R.

“…► Intranasal siRNA penetrates the olfactory epithelium and lamina propria. ► The olfactory nerve mediates intranasal delivery of siRNA to the olfactory bulb. ►…”
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Protective effects of intranasal losartan in the APP/PS1 transgenic mouse model of Alzheimer disease by Danielyan, Lusine, Klein, Roman, Hanson, Leah R, Buadze, Marine, Schwab, Matthias, Gleiter, Christoph H, Frey, William H

“…The local renin-angiotensin system (RAS) in the brain is a multitasking system controlling a plethora of essential functions such as neurogenic hypertension,…”
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Novel vasoconstrictor formulation to enhance intranasal targeting of neuropeptide therapeutics to the central nervous system by Dhuria, Shyeilla V, Hanson, Leah R, Frey, 2nd, William H

“…The intranasal route of drug administration is noninvasive, convenient, and rapidly targets therapeutics to the central nervous system (CNS) using olfactory…”
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