Search Results - "Hanson, Gunnar J"

Perfluoroaryl Bicyclic Cell‐Penetrating Peptides for Delivery of Antisense Oligonucleotides by Wolfe, Justin M., Fadzen, Colin M., Holden, Rebecca L., Yao, Monica, Hanson, Gunnar J., Pentelute, Bradley L.

“…Exon‐skipping antisense oligonucleotides are effective treatments for genetic diseases, yet exon‐skipping activity requires that these macromolecules reach the…”
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Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers by Li, Chengxi, Callahan, Alex J., Simon, Mark D., Totaro, Kyle A., Mijalis, Alexander J., Phadke, Kruttika-Suhas, Zhang, Genwei, Hartrampf, Nina, Schissel, Carly K., Zhou, Ming, Zong, Hong, Hanson, Gunnar J., Loas, Andrei, Pohl, Nicola L. B., Verhoeven, David E., Pentelute, Bradley L.

“…Rapid development of antisense therapies can enable on-demand responses to new viral pathogens and make personalized medicine for genetic diseases practical…”
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Functional muscle recovery following dystrophin and myostatin exon splice modulation in aged mdx mice by Lu-Nguyen, Ngoc, Ferry, Arnaud, Schnell, Frederick J, Hanson, Gunnar J, Popplewell, Linda, Dickson, George, Malerba, Alberto

“…Duchenne muscular dystrophy (DMD) is a rare genetic disease affecting 1 in 3500-5000 newborn boys. It is due to mutations in the DMD gene with a consequent…”
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A cell-penetrating peptide enhances delivery and efficacy of phosphorodiamidate morpholino oligomers in mdx mice by Gan, Li, Wu, Leslie C.L., Wood, Jenna A., Yao, Monica, Treleaven, Chris M., Estrella, Nelsa L., Wentworth, Bruce M., Hanson, Gunnar J., Passini, Marco A.

“…Antisense RNA technology is a strategy for the treatment of Duchenne muscular dystrophy (DMD), a progressive and universally fatal X-linked neuromuscular…”
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Machine Learning To Predict Cell-Penetrating Peptides for Antisense Delivery by Wolfe, Justin M., Fadzen, Colin M., Choo, Zi-Ning, Holden, Rebecca L., Yao, Monica, Hanson, Gunnar J., Pentelute, Bradley L.

“…Cell-penetrating peptides (CPPs) can facilitate the intracellular delivery of large therapeutically relevant molecules, including proteins and…”
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Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90 by BARTA, Thomas E, VEAL, James M, BARABASZ, Amy F, FOLEY, Briana E, OTTO, James, HALL, Steven E, RICE, John W, PARTRIDGE, Jeffrey M, FADDEN, R. Patrick, WEI MA, JENKS, Matthew, LIFENG GENG, HANSON, Gunnar J, HUANG, Kenneth H

“…Hsp90 maintains the conformational stability of multiple proteins implicated in oncogenesis and has emerged as a target for chemotherapy. We report here the…”
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Synthesis, Crystal Structure, and Activity of Pyrazole-Based Inhibitors of p38 Kinase by Graneto, Matthew J, Kurumbail, Ravi G, Vazquez, Michael L, Shieh, Huey-Sheng, Pawlitz, Jennifer L, Williams, Jennifer M, Stallings, William C, Geng, Lifeng, Naraian, Ashok S, Koszyk, Francis J, Stealey, Michael A, Xu, Xiangdong D, Weier, Richard M, Hanson, Gunnar J, Mourey, Robert J, Compton, Robert P, Mnich, Stephen J, Anderson, Gary D, Monahan, Joseph B, Devraj, Rajesh

“…A series of pyrazole inhibitors of p38 mitogen-activated protein (MAP) kinase were designed using a binding model based on the crystal structure of 1 (SC-102)…”
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Chimeras of Cell-Penetrating Peptides Demonstrate Synergistic Improvement in Antisense Efficacy by Fadzen, Colin M, Holden, Rebecca L, Wolfe, Justin M, Choo, Zi-Ning, Schissel, Carly K, Yao, Monica, Hanson, Gunnar J, Pentelute, Bradley L

“…Phosphorodiamidate morpholino oligonucleotides (PMOs) make up a promising class of therapeutics for genetic disease. PMOs designed for “exon skipping” must be…”
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Perfluoroaryl Bicyclic Cell‐Penetrating Peptides for Delivery of Antisense Oligonucleotides by Wolfe, Justin M., Fadzen, Colin M., Holden, Rebecca L., Yao, Monica, Hanson, Gunnar J., Pentelute, Bradley L.

“…Exon‐skipping antisense oligonucleotides are effective treatments for genetic diseases, yet exon‐skipping activity requires that these macromolecules reach the…”
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Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90 by Huang, Kenneth H., Barta, Thomas E., Rice, John W., Smith, Emilie D., Ommen, Andy J., Ma, Wei, Veal, James M., Fadden, R. Patrick, Barabasz, Amy F., Foley, Briana E., Hughes, Philip F., Hanson, Gunnar J., Markworth, Christopher J., Silinski, Melanie, Partridge, Jeffrey M., Steed, Paul M., Hall, Steven E.

“…Compound affinity to Hsp90 in Kd and cellular activities in IC50. A novel class of Hsp90 inhibitors, structurally distinct from previously reported scaffolds,…”
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Novel carbazole and acyl-indole antimitotics by Barta, Thomas E., Barabasz, Amy F., Foley, Briana E., Geng, Lifeng, Hall, Steven E., Hanson, Gunnar J., Jenks, Matthew, Ma, Wei, Rice, John W., Veal, James

“…In the course of our Heat Shock 90 program, certain carbazole compounds were identified which had an off-target antiproliferative activity. To understand the…”
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Synthesis of new dipeptide analogs containing novel ketovinyl and hydroxyethylidene isosteres via Grignard addition to chiral .alpha.-amino aldehydes by Hanson, Gunnar J, Lindberg, Thomas

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Development of PPMO for the Treatment of Duchenne Muscular Dystrophy (P5.430) by Passini, Marco A., Gan, Li, Wood, Jenna A., Yao, Monica, Estrella, Nelsa L., Treleaven, Chris M., Wentworth, Bruce M., Charleston, Jay S., Rutkowski, Joseph V., Hanson, Gunnar J.

“…Abstract only…”
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Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents by Huang, Kenneth H, Veal, James M, Fadden, R. Patrick, Rice, John W, Eaves, Jeron, Strachan, Jon-Paul, Barabasz, Amy F, Foley, Briana E, Barta, Thomas E, Ma, Wei, Silinski, Melanie A, Hu, Mei, Partridge, Jeffrey M, Scott, Anisa, DuBois, Laura G, Freed, Tiffany, Steed, Paul M, Ommen, Andy J, Smith, Emilie D, Hughes, Philip F, Woodward, Angela R, Hanson, Gunnar J, McCall, W. Stephen, Markworth, Christopher J, Hinkley, Lindsay, Jenks, Matthew, Geng, Lifeng, Lewis, Meredith, Otto, James, Pronk, Bert, Verleysen, Katleen, Hall, Steven E

“…A novel class of heat shock protein 90 (Hsp90) inhibitors was developed from an unbiased screen to identify protein targets for a diverse compound library…”
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A peptidomimetic that specifically inhibits human leukocyte antigen DRB10401-restricted T cell proliferation by Woulfe, S L, Bono, C P, Zacheis, M L, Welply, J K, Kirschmann, D A, Baudino, T A, Wang, Y, Stone, D A, Hanson, G J, Vuletich, J L, Bedell, L J, Schwartz, B D, Howard, S C

“…The ability of a peptidomimetic (SC-67655) to block the peptide binding site of the rheumatoid arthritis-linked human leukocyte antigen encoded by the…”
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Effects of SC-56525, a Potent, Orally Active Renin Inhibitor, in Salt-Depleted and Renal Hypertensive Dogs by McMahon, Ellen G, Yang, Po-Chang, Babler, Maribeth A, Bittner, Stephen E, Suleymanov, Osman D, Cain-Janicki, Kimberly J, Bedell, Louis J, Hanson, Gunnar J, Cook, Chyung S

“…SC-56525 is a nanomolar inhibitor of plasma renin activity in human, cynomolgus monkey, dog, guinea pig, Yucatan micropig, and rabbit but is less active in…”
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Discovery of benzamide tetrahydro-4 H-carbazol-4-ones as novel small molecule inhibitors of Hsp90 by Barta, Thomas E., Veal, James M., Rice, John W., Partridge, Jeffrey M., Fadden, R. Patrick, Ma, Wei, Jenks, Matthew, Geng, Lifeng, Hanson, Gunnar J., Huang, Kenneth H., Barabasz, Amy F., Foley, Briana E., Otto, James, Hall, Steven E.

“…Hsp90 maintains the conformational stability of multiple proteins implicated in oncogenesis and has emerged as a target for chemotherapy. We report here the…”
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DR (MHC class II) ligands: an approach to rheumatoid arthritis therapeutics by Hanson, G J

“…The presentation of peptide antigens to T-cells by MHC Class II proteins is a central process in cellular and humoral immune responses. Blockade of this…”
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Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90 by Fadden, Patrick, Huang, Kenneth H., Veal, James M., Steed, Paul M., Barabasz, Amy F., Foley, Briana, Hu, Mei, Partridge, Jeffrey M., Rice, John, Scott, Anisa, Dubois, Laura G., Freed, Tiffany A., Silinski, Melanie A. Rehder, Barta, Thomas E., Hughes, Philip F., Ommen, Andy, Ma, Wei, Smith, Emilie D., Spangenberg, Angela Woodward, Eaves, Jeron, Hanson, Gunnar J., Hinkley, Lindsay, Jenks, Matthew, Lewis, Meredith, Otto, James, Pronk, Gijsbertus J., Verleysen, Katleen, Haystead, Timothy A., Hall, Steven E.

“…A chemoproteomics-based drug discovery strategy is presented that utilizes a highly parallel screening platform, encompassing more than 1000 targets, with a…”
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Design of MHC class II (DR4) ligands using conformationally restricted imino acids at p3 and p5 by Hanson, Gunnar J., Vuletich, Jennifer L., Bedell, Louis J., Bono, Christine P., Howard, Susan C., Welply, Joseph K., Woulfe, Susan L., Zacheis, Michelle L.

“…High potency synthetic ligands were designed for rheumatoid arthritis linked Class II MHC, DR4 Dw4. The design strategy utilized isosteric replacements at the…”
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