Search Results - "Hanson, Douglas C."

Paclitaxel reduces regulatory T cell numbers and inhibitory function and enhances the anti-tumor effects of the TLR9 agonist PF-3512676 in the mouse by Vicari, Alain P, Luu, Rachel, Zhang, Ningli, Patel, Shobhna, Makinen, Shawn R, Hanson, Douglas C, Weeratna, Risini D, Krieg, Arthur M

“…The anti-tumor properties of Toll-like receptor (TLR) 9 agonist CpG oligodeoxynucleotides (ODN) are enhanced by combinations with several cytotoxic…”
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Tremelimumab (CP‐675,206), a Cytotoxic T Lymphocyte–Associated Antigen 4 Blocking Monoclonal Antibody in Clinical Development for Patients with Cancer by Ribas, Antoni, Hanson, Douglas C., Noe, Dennis A., Millham, Robert, Guyot, Deborah J., Bernstein, Steven H., Canniff, Paul C., Sharma, Amarnath, Gomez‐Navarro, Jesus

“…Learning Objectives After completing the course, the reader will be able to: Educate community oncologists about the promise of anti‐CTLA‐4 monoclonal…”
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UK‐78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage‐gated potassium channel and inhibits human T cell activation by Hanson, Douglas C, Nguyen, Angela, Mather, Robert J, Rauer, Heiko, Koch, Kevin, Burgess, Laurence E, Rizzi, James P, Donovan, Carol B, Bruns, Matthew J, Canniff, Paul C, Cunningham, Ann C, Verdries, Kimberly A, Mena, Edward, Kath, John C, Gutman, George A, Cahalan, Michael D, Grissmer, Stephan, Chandy, K George

“…UK‐78,282, a novel piperidine blocker of the T lymphocyte voltage‐gated K+ channel, Kv1.3, was discovered by screening a large compound file using a…”
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Chemistry of singlet oxygen. 47. 9,10-Dicyanoanthracene-sensitized photooxygenation of alkyl-substituted olefins by Araki, Yasuhiko, Dobrowolski, Diane C, Goyne, Thomas E, Hanson, Douglas C, Jiang, Zhi Qin, Lee, Kenneth J, Foote, Christopher S

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Segmental flexibility of immunoglobulin G antibody molecules in solution: a new interpretation by Hanson, Douglas C, Yguerabide, Juan, Schumaker, Verne N

“…We propose a new model for the segmental flexibility of immunoglobulin G (IgG). The flexibility of native and mildly reduced…”
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The C-32 Triacetyl-L-rhamnose Derivative of Ascomycin: A Potent, Orally Active Macrolactone Immunosuppressant by Koch, Kevin, Newborg, Michael F, Hanson, Douglas C, Cooper, Kelvin, Shepard, Richard M, Biehl, Michael L, Biggers, Michael S, Ramchandani, Mukesh, Schulte, Gary

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A molecular mechanism for the activation of the first component of complement by immune complexes by Schumaker, V N, Hanson, D C, Kilchherr, E, Phillips, M L, Poon, P H

“…The proposed activation mechanism is based upon several key concepts, including the "S"-structure for the folding of the C1r2C1s2 tetramer among the C1q arms…”
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Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines by Grissmer, S, Nguyen, A N, Aiyar, J, Hanson, D C, Mather, R J, Gutman, G A, Karmilowicz, M J, Auperin, D D, Chandy, K G

“…We have analyzed the biophysical and pharmacological properties of five cloned K+ (Kv) channels (Kv1.1, Kv1.2, Kv1.3, Kv1.5, and Kv3.1) stably expressed in…”
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Topology of the pore-region of a K + channel revealed by the NMR-derived structures of scorpion toxins by Aiyar, Jayashree, Withka, Jane M., Rizzi, James P., Singleton, David H., Andrews, Glenn C., Lin, Wen, Boyd, James, Hanson, Douglas C., Simon, Mariella, Dethlefs, Brent, Lee, Chao-lin, Hall, James E., Gutman, George A., George Chandy, K.

“…The architecture of the pore-region of a voltage-gated K + channel, Kv1.3, was probed using four high affinity scorpion toxins as molecular calipers. We…”
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Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation by Nguyen, A, Kath, J C, Hanson, D C, Biggers, M S, Canniff, P C, Donovan, C B, Mather, R J, Bruns, M J, Rauer, H, Aiyar, J, Lepple-Wienhues, A, Gutman, G A, Grissmer, S, Cahalan, M D, Chandy, K G

“…The nonpeptide agent CP-339,818 (1-benzyl-4-pentylimino-1,4-dihydroquinoline) and two analogs (CP-393,223 and CP-394,322) that differ only with respect to the…”
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The SAR of UK-78,282: A novel blocker of human T cell Kv1.3 potassium channels by Burgess, Laurence E., Koch, Kevin, Cooper, Kelvin, Biggers, Michael S., Ramchandani, Mukesh, Smitrovich, Jacqueline H., Gilbert, Eric J., Bruns, Matthew J., Mather, Robert J., Donovan, Carol B., Hanson, Douglas C.

“…UK-78,282 was identified in a human T cell 86Rb efflux high-throughput screen of our compound libraries. This compound was found to be a potent and selective…”
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Inhibition of interleukin 1 synthesis by tenidap: a new drug for arthritis by Otterness, I G, Bliven, M L, Downs, J T, Natoli, E J, Hanson, D C

“…Tenidap is a new antiarthritic drug of novel chemical structure. This study shows the effects of tenidap on the in vitro synthesis of interleukin 1 (IL-1)…”
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Dynamic aspects of antibody structure by Schumaker, V N, Phillips, M L, Hanson, D C

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The pharmacologic regulation of interleukin-1 production: the role of prostaglandins by Otterness, I G, Bliven, M L, Eskra, J D, Reinke, M, Hanson, D C

“…The role of prostaglandins in the regulation of lipopolysaccharide (LPS)-induced interleukin-1 (IL-1) production by murine C3H/HeN resident peritoneal…”
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Some theoretical considerations regarding the effects of steric hindrance and intrinsic global coupling on the flexibility of Fc-anchored immunoglobulins by Hanson, D C

“…Nanosecond fluorescence depolarization studies reported in the accompanying companion paper showed that the long rotational correlation time, phi L, increased…”
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Immunoglobulin G antibody bound to the C1q subcomponent of human complement exhibits segmental flexibility by Hanson, D C, Schumaker, V N

“…The rotational dynamics of rabbit immunoglobulin G (IgG) anti-dansyl antibodies bound to the C1q subcomponent of human complement were studied by nanosecond…”
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Rotational dynamics of immunoglobulin G antibodies anchored in protein A soluble complexes by Hanson, D C, Yguerabide, J, Schumaker, V N

“…The rotational dynamics of rabbit IgG anti-dansyl antibodies anchored in staphylococcal protein A (SpA) soluble complexes were studied by both steady-state and…”
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Comparison of histocompatibility antigens on cultured human tumor cells and fibroblasts by quantitative antibody absorption and sensitivity to cell-mediated cytotoxicity by Golub, S H, Hanson, D C, Sulit, H L, Morton, D L, Pellegrino, M A, Ferrone, S

“…Human tumor and febroblast tissue culture cells were compared to determine the suitability of fibroblasts as control cells in experiments on human tumor…”
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Human monocytes produce IL-1 and an inhibitor of IL-1 in response to two different signals by Schur, P H, Chang, D M, Baptiste, P, Uhteg, L C, Hanson, D C

“…Recently, IL-1 inhibitors from urine, monocytes, or monocyte lines have been described. The relationship of these inhibitors to the production, release, and…”
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